HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 951 Southeast Asia Malays from Peninsular Malaysia

Lay Kim Tan, Baharin Mohd-Farid, Sulaiman Salsabil, Hussein Heselynn, Sulaiman Wahinuddin, Ing Soo Lau, Suk Chyn Gun, Sharil Nor-Suhaila, M. Eashwary, Mohd Shahrir Mohamed Said, Mohd Mokhtar Ainon, Rosman Azmillah, Othman Muhaini, Murad Shahnaz, Chun Lai Too

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A total of 951 Southeast Asia Malays from Peninsular Malaysia were genotyped for HLA-A, -B, -C -DRB1, and -DQB1 loci using polymerase chain reaction sequence-specific oligonucleotide probe hybridization methods. In this report, there were significant deviation from Hardy-Weinberg proportions for the HLA-A (p < 0.0001), -B (p < 0.0001), -DRB1 (p < 0.0001) and -DQB1 (p < 0.01) loci. Minor deviations from HWEP were detected for HLA-C (p = 0.01). This genotype data was available in Allele Frequencies Network Database (AFND) Gonzalez-Galarza et al. (2015).

Original languageEnglish
Pages (from-to)818-819
Number of pages2
JournalHuman Immunology
Volume77
Issue number10
DOIs
Publication statusPublished - 1 Oct 2016

Fingerprint

Southeastern Asia
HLA-A Antigens
HLA-B Antigens
Malaysia
Haplotypes
Alleles
HLA-C Antigens
Oligonucleotide Probes
Gene Frequency
Genotype
Databases
Polymerase Chain Reaction

Keywords

  • Genetic
  • HLA alleles
  • Malays
  • Population

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Tan, L. K., Mohd-Farid, B., Salsabil, S., Heselynn, H., Wahinuddin, S., Lau, I. S., ... Too, C. L. (2016). HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 951 Southeast Asia Malays from Peninsular Malaysia. Human Immunology, 77(10), 818-819. https://doi.org/10.1016/j.humimm.2016.06.022

HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 951 Southeast Asia Malays from Peninsular Malaysia. / Tan, Lay Kim; Mohd-Farid, Baharin; Salsabil, Sulaiman; Heselynn, Hussein; Wahinuddin, Sulaiman; Lau, Ing Soo; Gun, Suk Chyn; Nor-Suhaila, Sharil; Eashwary, M.; Mohamed Said, Mohd Shahrir; Ainon, Mohd Mokhtar; Azmillah, Rosman; Muhaini, Othman; Shahnaz, Murad; Too, Chun Lai.

In: Human Immunology, Vol. 77, No. 10, 01.10.2016, p. 818-819.

Research output: Contribution to journalArticle

Tan, LK, Mohd-Farid, B, Salsabil, S, Heselynn, H, Wahinuddin, S, Lau, IS, Gun, SC, Nor-Suhaila, S, Eashwary, M, Mohamed Said, MS, Ainon, MM, Azmillah, R, Muhaini, O, Shahnaz, M & Too, CL 2016, 'HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 951 Southeast Asia Malays from Peninsular Malaysia', Human Immunology, vol. 77, no. 10, pp. 818-819. https://doi.org/10.1016/j.humimm.2016.06.022
Tan, Lay Kim ; Mohd-Farid, Baharin ; Salsabil, Sulaiman ; Heselynn, Hussein ; Wahinuddin, Sulaiman ; Lau, Ing Soo ; Gun, Suk Chyn ; Nor-Suhaila, Sharil ; Eashwary, M. ; Mohamed Said, Mohd Shahrir ; Ainon, Mohd Mokhtar ; Azmillah, Rosman ; Muhaini, Othman ; Shahnaz, Murad ; Too, Chun Lai. / HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 951 Southeast Asia Malays from Peninsular Malaysia. In: Human Immunology. 2016 ; Vol. 77, No. 10. pp. 818-819.
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