HLA-A and breast cancer in West Peninsular Malaysia

Pooi Pooi Leong, Rohaizak Muhammad, Naqiyah Ibrahim, Soon Keng Cheong, Heng Fong Seow

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Breast cancer is the most common malignancy among females in Malaysia. Attempts have been made to investigate the association between breast cancer and human leukocyte antigen (HLA) types. However, data from those previous studies are highly variable. The aim of this study is to investigate the association between HLA-A types and clinicopathological factors in breast cancer. The frequencies of HLA-A type in 59 female patients with infiltrating ductal of the breast were determined by polymerase chain reaction method. HLA-A2/A30 and A2/A31 haplotype (5.1%; P = 0.045) as well as HLA-A30 (5.1%, P = 0.045) and A31 (6.8%; P = 0.020) allele were significant higher in the patients than controls (0%). HLA-A24 allele was negatively related to lymph node metastasis (r = -0.316; P = 0.021) whereas, A26 (r = -0.430; P = 0.001) and A36 (r = -0.430; P = 0.001) alleles were negatively correlated to distant metastasis in breast cancer. Negative correlations between HLA-A26/A36 (r = -0.430; P = 0.001), A2/A11 (r = -0.276; P = 0.044), A24/A34 (r = -0.430; P = 0.001) haplotypes and distant metastasis were identified. Interestingly, Her2 expression in breast carcinoma was negatively correlated to A11/24 haplotypes (r = -0.294; P = 0.034) but positively correlated to homozygous HLA-A24 (r = 0.396; P = 0.040). In conclusion, HLA-A2, -A30 and A31 were associated with breast cancer.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalMedical Oncology
Volume28
Issue number1
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Malaysia
HLA Antigens
Breast Neoplasms
varespladib methyl
Haplotypes
faropenem medoxomil
Alleles
Neoplasm Metastasis
Breast
Lymph Nodes
Polymerase Chain Reaction

Keywords

  • Breast cancer
  • Her2
  • Heterzygous
  • HLA-A
  • Homozygous
  • Metastasis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Hematology

Cite this

Leong, P. P., Muhammad, R., Ibrahim, N., Cheong, S. K., & Seow, H. F. (2011). HLA-A and breast cancer in West Peninsular Malaysia. Medical Oncology, 28(1), 51-56. https://doi.org/10.1007/s12032-009-9414-6

HLA-A and breast cancer in West Peninsular Malaysia. / Leong, Pooi Pooi; Muhammad, Rohaizak; Ibrahim, Naqiyah; Cheong, Soon Keng; Seow, Heng Fong.

In: Medical Oncology, Vol. 28, No. 1, 03.2011, p. 51-56.

Research output: Contribution to journalArticle

Leong, PP, Muhammad, R, Ibrahim, N, Cheong, SK & Seow, HF 2011, 'HLA-A and breast cancer in West Peninsular Malaysia', Medical Oncology, vol. 28, no. 1, pp. 51-56. https://doi.org/10.1007/s12032-009-9414-6
Leong, Pooi Pooi ; Muhammad, Rohaizak ; Ibrahim, Naqiyah ; Cheong, Soon Keng ; Seow, Heng Fong. / HLA-A and breast cancer in West Peninsular Malaysia. In: Medical Oncology. 2011 ; Vol. 28, No. 1. pp. 51-56.
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