Histological analysis of anti-cancer drug loaded, targeted Mn

ZnS quantum dots in metastatic lesions of 4T1 challenged mice

Ibrahim Birma Bwatanglang, Faruq Mohammad, Nor Azah Yusof, Nurul Elyani Mohammed, Nadiah Abu, Noorjahan Banu Alitheen, Jaafar Abdullah, Mohd Zubir Hussein, Yusuf Abba, Noraini Nordin, Nur Rizi Zamberi

Research output: Contribution to journalArticle

Abstract

Abstract: 5-Fluororaucil (5-FU) as anti-cancer drug was reported to induce thymidine synthase (TS) overexpression and cancer cell resistance. To improve its therapeutic efficacy and selective targeting, here we developed a targeted delivery system mediated by the active ligand-folate receptor chemistry to deliver the 5-FU drug selectively into the tumor microenvironment. The preparation was achieved by exploring chitosan (CS)-biopolymer based system with folic acid (FA)-conjugation. The 5-FU@FACS-Mn:ZnS quantum dots (QDs) based on the histological assessment conducted in the 4T1 challenged mice showed an improved tumor remission in the liver, spleen and lungs. The 5-FU@FACS-Mn:ZnS composite induced anti-proliferative properties in these organs as compared to the free 5-FU drug. Unlike the 5-FU@FACS-Mn:ZnS treated groups which showed some specific morphological changes such as cell shrinkage without obvious presence of adipocytes, the excised section of the tumor in the untreated control group and the free 5-FU drug treated group showed necrotic and degenerated cells; these cells are multifocally distributed in the tumor mass with evidence of widely distributed adipocytes within the tumor mass. These findings suggest that the 5-FU@FACS-Mn:ZnS composite has a superior role during the induction of apoptosis in the 4T1 cells as compared to the free 5-FU drug treated groups. The results of the study therefore suggest that the impregnation of 5-FU anti-cancer drug within the FACS-Mn:ZnS system significantly improves its selective targeting efficacy, in addition to improving the anti-proliferative properties and attenuate possible tumor resistances to the 5-FU drug. Graphical abstract: The work discusses about the anti-metastatic effects of folic acid-bound 5-Fluororacil loaded Mn:ZnS quantum dots towards 4T1 cell line proliferation in mice based on the histological analysis. [InlineMediaObject not available: see fulltext.].

Original languageEnglish
Article number138
JournalJournal of Materials Science: Materials in Medicine
Volume28
Issue number9
DOIs
Publication statusPublished - 1 Sep 2017
Externally publishedYes

Fingerprint

Quantum Dots
Semiconductor quantum dots
Tumors
Pharmaceutical Preparations
Folic Acid
Neoplasms
Cells
Adipocytes
Acids
Biopolymers
Composite materials
Cell death
Chitosan
Impregnation
Liver
Tumor Microenvironment
Thymidine
Ligands
Apoptosis
Spleen

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Histological analysis of anti-cancer drug loaded, targeted Mn : ZnS quantum dots in metastatic lesions of 4T1 challenged mice. / Birma Bwatanglang, Ibrahim; Mohammad, Faruq; Yusof, Nor Azah; Elyani Mohammed, Nurul; Abu, Nadiah; Alitheen, Noorjahan Banu; Abdullah, Jaafar; Zubir Hussein, Mohd; Abba, Yusuf; Nordin, Noraini; Rizi Zamberi, Nur.

In: Journal of Materials Science: Materials in Medicine, Vol. 28, No. 9, 138, 01.09.2017.

Research output: Contribution to journalArticle

Birma Bwatanglang, I, Mohammad, F, Yusof, NA, Elyani Mohammed, N, Abu, N, Alitheen, NB, Abdullah, J, Zubir Hussein, M, Abba, Y, Nordin, N & Rizi Zamberi, N 2017, 'Histological analysis of anti-cancer drug loaded, targeted Mn: ZnS quantum dots in metastatic lesions of 4T1 challenged mice', Journal of Materials Science: Materials in Medicine, vol. 28, no. 9, 138. https://doi.org/10.1007/s10856-017-5949-9
Birma Bwatanglang, Ibrahim ; Mohammad, Faruq ; Yusof, Nor Azah ; Elyani Mohammed, Nurul ; Abu, Nadiah ; Alitheen, Noorjahan Banu ; Abdullah, Jaafar ; Zubir Hussein, Mohd ; Abba, Yusuf ; Nordin, Noraini ; Rizi Zamberi, Nur. / Histological analysis of anti-cancer drug loaded, targeted Mn : ZnS quantum dots in metastatic lesions of 4T1 challenged mice. In: Journal of Materials Science: Materials in Medicine. 2017 ; Vol. 28, No. 9.
@article{d644104878a842de9aa95766f34feb55,
title = "Histological analysis of anti-cancer drug loaded, targeted Mn: ZnS quantum dots in metastatic lesions of 4T1 challenged mice",
abstract = "Abstract: 5-Fluororaucil (5-FU) as anti-cancer drug was reported to induce thymidine synthase (TS) overexpression and cancer cell resistance. To improve its therapeutic efficacy and selective targeting, here we developed a targeted delivery system mediated by the active ligand-folate receptor chemistry to deliver the 5-FU drug selectively into the tumor microenvironment. The preparation was achieved by exploring chitosan (CS)-biopolymer based system with folic acid (FA)-conjugation. The 5-FU@FACS-Mn:ZnS quantum dots (QDs) based on the histological assessment conducted in the 4T1 challenged mice showed an improved tumor remission in the liver, spleen and lungs. The 5-FU@FACS-Mn:ZnS composite induced anti-proliferative properties in these organs as compared to the free 5-FU drug. Unlike the 5-FU@FACS-Mn:ZnS treated groups which showed some specific morphological changes such as cell shrinkage without obvious presence of adipocytes, the excised section of the tumor in the untreated control group and the free 5-FU drug treated group showed necrotic and degenerated cells; these cells are multifocally distributed in the tumor mass with evidence of widely distributed adipocytes within the tumor mass. These findings suggest that the 5-FU@FACS-Mn:ZnS composite has a superior role during the induction of apoptosis in the 4T1 cells as compared to the free 5-FU drug treated groups. The results of the study therefore suggest that the impregnation of 5-FU anti-cancer drug within the FACS-Mn:ZnS system significantly improves its selective targeting efficacy, in addition to improving the anti-proliferative properties and attenuate possible tumor resistances to the 5-FU drug. Graphical abstract: The work discusses about the anti-metastatic effects of folic acid-bound 5-Fluororacil loaded Mn:ZnS quantum dots towards 4T1 cell line proliferation in mice based on the histological analysis. [InlineMediaObject not available: see fulltext.].",
author = "{Birma Bwatanglang}, Ibrahim and Faruq Mohammad and Yusof, {Nor Azah} and {Elyani Mohammed}, Nurul and Nadiah Abu and Alitheen, {Noorjahan Banu} and Jaafar Abdullah and {Zubir Hussein}, Mohd and Yusuf Abba and Noraini Nordin and {Rizi Zamberi}, Nur",
year = "2017",
month = "9",
day = "1",
doi = "10.1007/s10856-017-5949-9",
language = "English",
volume = "28",
journal = "Journal of Materials Science: Materials in Medicine",
issn = "0957-4530",
publisher = "Springer Netherlands",
number = "9",

}

TY - JOUR

T1 - Histological analysis of anti-cancer drug loaded, targeted Mn

T2 - ZnS quantum dots in metastatic lesions of 4T1 challenged mice

AU - Birma Bwatanglang, Ibrahim

AU - Mohammad, Faruq

AU - Yusof, Nor Azah

AU - Elyani Mohammed, Nurul

AU - Abu, Nadiah

AU - Alitheen, Noorjahan Banu

AU - Abdullah, Jaafar

AU - Zubir Hussein, Mohd

AU - Abba, Yusuf

AU - Nordin, Noraini

AU - Rizi Zamberi, Nur

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Abstract: 5-Fluororaucil (5-FU) as anti-cancer drug was reported to induce thymidine synthase (TS) overexpression and cancer cell resistance. To improve its therapeutic efficacy and selective targeting, here we developed a targeted delivery system mediated by the active ligand-folate receptor chemistry to deliver the 5-FU drug selectively into the tumor microenvironment. The preparation was achieved by exploring chitosan (CS)-biopolymer based system with folic acid (FA)-conjugation. The 5-FU@FACS-Mn:ZnS quantum dots (QDs) based on the histological assessment conducted in the 4T1 challenged mice showed an improved tumor remission in the liver, spleen and lungs. The 5-FU@FACS-Mn:ZnS composite induced anti-proliferative properties in these organs as compared to the free 5-FU drug. Unlike the 5-FU@FACS-Mn:ZnS treated groups which showed some specific morphological changes such as cell shrinkage without obvious presence of adipocytes, the excised section of the tumor in the untreated control group and the free 5-FU drug treated group showed necrotic and degenerated cells; these cells are multifocally distributed in the tumor mass with evidence of widely distributed adipocytes within the tumor mass. These findings suggest that the 5-FU@FACS-Mn:ZnS composite has a superior role during the induction of apoptosis in the 4T1 cells as compared to the free 5-FU drug treated groups. The results of the study therefore suggest that the impregnation of 5-FU anti-cancer drug within the FACS-Mn:ZnS system significantly improves its selective targeting efficacy, in addition to improving the anti-proliferative properties and attenuate possible tumor resistances to the 5-FU drug. Graphical abstract: The work discusses about the anti-metastatic effects of folic acid-bound 5-Fluororacil loaded Mn:ZnS quantum dots towards 4T1 cell line proliferation in mice based on the histological analysis. [InlineMediaObject not available: see fulltext.].

AB - Abstract: 5-Fluororaucil (5-FU) as anti-cancer drug was reported to induce thymidine synthase (TS) overexpression and cancer cell resistance. To improve its therapeutic efficacy and selective targeting, here we developed a targeted delivery system mediated by the active ligand-folate receptor chemistry to deliver the 5-FU drug selectively into the tumor microenvironment. The preparation was achieved by exploring chitosan (CS)-biopolymer based system with folic acid (FA)-conjugation. The 5-FU@FACS-Mn:ZnS quantum dots (QDs) based on the histological assessment conducted in the 4T1 challenged mice showed an improved tumor remission in the liver, spleen and lungs. The 5-FU@FACS-Mn:ZnS composite induced anti-proliferative properties in these organs as compared to the free 5-FU drug. Unlike the 5-FU@FACS-Mn:ZnS treated groups which showed some specific morphological changes such as cell shrinkage without obvious presence of adipocytes, the excised section of the tumor in the untreated control group and the free 5-FU drug treated group showed necrotic and degenerated cells; these cells are multifocally distributed in the tumor mass with evidence of widely distributed adipocytes within the tumor mass. These findings suggest that the 5-FU@FACS-Mn:ZnS composite has a superior role during the induction of apoptosis in the 4T1 cells as compared to the free 5-FU drug treated groups. The results of the study therefore suggest that the impregnation of 5-FU anti-cancer drug within the FACS-Mn:ZnS system significantly improves its selective targeting efficacy, in addition to improving the anti-proliferative properties and attenuate possible tumor resistances to the 5-FU drug. Graphical abstract: The work discusses about the anti-metastatic effects of folic acid-bound 5-Fluororacil loaded Mn:ZnS quantum dots towards 4T1 cell line proliferation in mice based on the histological analysis. [InlineMediaObject not available: see fulltext.].

UR - http://www.scopus.com/inward/record.url?scp=85027021798&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027021798&partnerID=8YFLogxK

U2 - 10.1007/s10856-017-5949-9

DO - 10.1007/s10856-017-5949-9

M3 - Article

VL - 28

JO - Journal of Materials Science: Materials in Medicine

JF - Journal of Materials Science: Materials in Medicine

SN - 0957-4530

IS - 9

M1 - 138

ER -