Highly selective dengue virus detection using carbon nanotubes: Effect of pulse biasing in serum

Seok Hyang Kim, Young June Park, Jun Myung Woo, Burhanuddin Yeop Majlis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Electrical pulse biasing was used for selective and sensitive detection in serum of a target DNA sequence (dengue fever virus-specific sequence in this study) based on a carbon nanotube network decorated with gold nano particles. A significant increase in the affinity constant (as much as 1.01×109 M-1 from the Langmuir fitting) has been obtained in addition to the enhancement in selectivity against the nonselective molecules. The physical reason of the enhancement is believed to be the physical oscillation of the probe DNA molecules caused by the applied electrical pulse trains, thereby increase in the binding chance between the probe and target DNA's. With the technique, a wide dynamic range (10 pM-10 μM) detection of the target DNA molecules has been achieved in the serum condition.

Original languageEnglish
Title of host publicationIEEE-NANO 2015 - 15th International Conference on Nanotechnology
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1066-1069
Number of pages4
ISBN (Print)9781467381550
DOIs
Publication statusPublished - 20 Jan 2016
Event15th IEEE International Conference on Nanotechnology, IEEE-NANO 2015 - Rome, Italy
Duration: 27 Jul 201530 Jul 2015

Other

Other15th IEEE International Conference on Nanotechnology, IEEE-NANO 2015
CountryItaly
CityRome
Period27/7/1530/7/15

Fingerprint

Carbon Nanotubes
Viruses
Carbon nanotubes
DNA
Molecules
DNA sequences
DNA Probes
Gold

Keywords

  • Carbon nanotube
  • Device
  • Nanosensor

ASJC Scopus subject areas

  • Process Chemistry and Technology
  • Electrical and Electronic Engineering
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films

Cite this

Kim, S. H., Park, Y. J., Woo, J. M., & Yeop Majlis, B. (2016). Highly selective dengue virus detection using carbon nanotubes: Effect of pulse biasing in serum. In IEEE-NANO 2015 - 15th International Conference on Nanotechnology (pp. 1066-1069). [7388805] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NANO.2015.7388805

Highly selective dengue virus detection using carbon nanotubes : Effect of pulse biasing in serum. / Kim, Seok Hyang; Park, Young June; Woo, Jun Myung; Yeop Majlis, Burhanuddin.

IEEE-NANO 2015 - 15th International Conference on Nanotechnology. Institute of Electrical and Electronics Engineers Inc., 2016. p. 1066-1069 7388805.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kim, SH, Park, YJ, Woo, JM & Yeop Majlis, B 2016, Highly selective dengue virus detection using carbon nanotubes: Effect of pulse biasing in serum. in IEEE-NANO 2015 - 15th International Conference on Nanotechnology., 7388805, Institute of Electrical and Electronics Engineers Inc., pp. 1066-1069, 15th IEEE International Conference on Nanotechnology, IEEE-NANO 2015, Rome, Italy, 27/7/15. https://doi.org/10.1109/NANO.2015.7388805
Kim SH, Park YJ, Woo JM, Yeop Majlis B. Highly selective dengue virus detection using carbon nanotubes: Effect of pulse biasing in serum. In IEEE-NANO 2015 - 15th International Conference on Nanotechnology. Institute of Electrical and Electronics Engineers Inc. 2016. p. 1066-1069. 7388805 https://doi.org/10.1109/NANO.2015.7388805
Kim, Seok Hyang ; Park, Young June ; Woo, Jun Myung ; Yeop Majlis, Burhanuddin. / Highly selective dengue virus detection using carbon nanotubes : Effect of pulse biasing in serum. IEEE-NANO 2015 - 15th International Conference on Nanotechnology. Institute of Electrical and Electronics Engineers Inc., 2016. pp. 1066-1069
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