Highly potent stem cells from full-term amniotic fluid

A realistic perspective

Adila A. Hamid, Muhammad Khair Joharry, Hoo Mun-Fun, Siti Nurusaadah Hamzah, Zulida Rejali, Mohd Nazri Yazid, Thilakavathy Karuppiah, Norshariza Nordin

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Amniotic fluid (AF) is now known to harbor highly potent stem cells, making it an excellent source for cell therapy. However, most of the stem cells isolated are from AF of mid-term pregnancies in which the collection procedure involves an invasive technique termed amniocentesis. This has limited the access in getting the fluid as the technique imposes certain level of risks to the mother as well as to the fetus. Alternatively, getting AF from full-term pregnancies or during deliveries would be a better resolution. Unfortunately, very few studies have isolated stem cells from AF at this stage of gestation, the fluid that is merely discarded. The question remains whether full-term AF harbors stem cells of similar potency as of the stem cells of mid-term AF. Here, we aim to review the prospect of having this type of stem cells by first looking at the origin and contents of AF particularly during different gestation period. We will then discuss the possibility that the AF, at full term, contains a population of highly potent stem cells. These stem cells are distinct from, and probably more potent than the AF mesenchymal stem cells (AF-MSCs) isolated from full-term AF. By comparing the studies on stem cells isolated from mid-term versus full-term AF from various species, we intend to address the prospect of having highly potent amniotic fluid stem cells from AF of full-term pregnancies in human and animals.

Original languageEnglish
Pages (from-to)9-18
Number of pages10
JournalReproductive biology
Volume17
Issue number1
DOIs
Publication statusPublished - 1 Mar 2017

Fingerprint

amniotic fluid
Amniotic Fluid
stem cells
Stem Cells
Pregnancy
pregnancy
Amniocentesis
gestation period
Cell- and Tissue-Based Therapy
Mesenchymal Stromal Cells
fetus

Keywords

  • Amniotic fluid mesenchymal stem cells
  • Amniotic fluid stem cells
  • Full-term amniotic fluid
  • Pluripotent

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology
  • Developmental Biology

Cite this

A. Hamid, A., Joharry, M. K., Mun-Fun, H., Hamzah, S. N., Rejali, Z., Yazid, M. N., ... Nordin, N. (2017). Highly potent stem cells from full-term amniotic fluid: A realistic perspective. Reproductive biology, 17(1), 9-18. https://doi.org/10.1016/j.repbio.2017.02.001

Highly potent stem cells from full-term amniotic fluid : A realistic perspective. / A. Hamid, Adila; Joharry, Muhammad Khair; Mun-Fun, Hoo; Hamzah, Siti Nurusaadah; Rejali, Zulida; Yazid, Mohd Nazri; Karuppiah, Thilakavathy; Nordin, Norshariza.

In: Reproductive biology, Vol. 17, No. 1, 01.03.2017, p. 9-18.

Research output: Contribution to journalReview article

A. Hamid, A, Joharry, MK, Mun-Fun, H, Hamzah, SN, Rejali, Z, Yazid, MN, Karuppiah, T & Nordin, N 2017, 'Highly potent stem cells from full-term amniotic fluid: A realistic perspective', Reproductive biology, vol. 17, no. 1, pp. 9-18. https://doi.org/10.1016/j.repbio.2017.02.001
A. Hamid, Adila ; Joharry, Muhammad Khair ; Mun-Fun, Hoo ; Hamzah, Siti Nurusaadah ; Rejali, Zulida ; Yazid, Mohd Nazri ; Karuppiah, Thilakavathy ; Nordin, Norshariza. / Highly potent stem cells from full-term amniotic fluid : A realistic perspective. In: Reproductive biology. 2017 ; Vol. 17, No. 1. pp. 9-18.
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