High prevalence of diabetes in stroke patients and its association with lacunar infarction

Zhe Kang Law, Wan Nur Nafisah Wan Yahya, Ramesh Sahathevan, Jee Yong Hing, Mohd Firdaus Zakaria, Nurul Munirah Mohd Shuhari, Nur Fathihah Ahmad, Teong Kui Ting, Hui Jan Tan, Shahrul Azmin Md. Rani, Rabani Remli, Azmawati Mohammed Nawi, Norlinah Mohamed Ibrahim

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Abstract

Background & Objectives: The burden of stroke is increasing, in part due to increasing prevalence of diabetes mellitus. Given the high prevalence of diabetes in the Malaysian population (22.6%), we aimed to determine the prevalence of diabetes in our stroke population. We also aimed to study the stroke subtype associated with diabetes. We hypothesized that lacunar infarction would be more prevalent in diabetics. Methods: We retrospectively reviewed data of consecutive patients with acute ischaemic stroke admitted from October 2004 to December 2010 from our stroke registry. Demographic data, risk factors profile and stroke subtypes were reviewed and analyzed. Results: Eight hundred and fifty eight patients were identified from the registry. As high as 59.3% (n=509) of our patients were diabetics, of which 49.2% (n=422) had pre-existing diabetes and 10.1% (n=87) were newly diagnosed. Lacunar infarction was the commonest stroke subtype, comprising 60.6% (n=519) of all strokes. Diabetes was significantly associated with lacunar infarction (OR 1.5, CI 95% 1.16-2.01, p=0.003), particularly in those aged < 55 years (OR 2.29, 95% CI 1.12-4.67) and HbA1C > 6.5% (x<sup>2</sup>=8.77, p=0.003). Conclusions: The prevalence of diabetes in our stroke patients is amongst the highest reported. Diabetes mellitus, particularly those with poor glycaemic control is strongly associated with lacunar infarction.

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalNeurology Asia
Volume20
Issue number2
Publication statusPublished - 1 Jun 2015

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Lacunar Stroke
Stroke
Registries
Diabetes Mellitus
Population
Demography

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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High prevalence of diabetes in stroke patients and its association with lacunar infarction. / Law, Zhe Kang; Wan Yahya, Wan Nur Nafisah; Sahathevan, Ramesh; Hing, Jee Yong; Zakaria, Mohd Firdaus; Mohd Shuhari, Nurul Munirah; Ahmad, Nur Fathihah; Ting, Teong Kui; Tan, Hui Jan; Md. Rani, Shahrul Azmin; Remli, Rabani; Mohammed Nawi, Azmawati; Mohamed Ibrahim, Norlinah.

In: Neurology Asia, Vol. 20, No. 2, 01.06.2015, p. 121-127.

Research output: Contribution to journalArticle

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abstract = "Background & Objectives: The burden of stroke is increasing, in part due to increasing prevalence of diabetes mellitus. Given the high prevalence of diabetes in the Malaysian population (22.6{\%}), we aimed to determine the prevalence of diabetes in our stroke population. We also aimed to study the stroke subtype associated with diabetes. We hypothesized that lacunar infarction would be more prevalent in diabetics. Methods: We retrospectively reviewed data of consecutive patients with acute ischaemic stroke admitted from October 2004 to December 2010 from our stroke registry. Demographic data, risk factors profile and stroke subtypes were reviewed and analyzed. Results: Eight hundred and fifty eight patients were identified from the registry. As high as 59.3{\%} (n=509) of our patients were diabetics, of which 49.2{\%} (n=422) had pre-existing diabetes and 10.1{\%} (n=87) were newly diagnosed. Lacunar infarction was the commonest stroke subtype, comprising 60.6{\%} (n=519) of all strokes. Diabetes was significantly associated with lacunar infarction (OR 1.5, CI 95{\%} 1.16-2.01, p=0.003), particularly in those aged < 55 years (OR 2.29, 95{\%} CI 1.12-4.67) and HbA1C > 6.5{\%} (x2=8.77, p=0.003). Conclusions: The prevalence of diabetes in our stroke patients is amongst the highest reported. Diabetes mellitus, particularly those with poor glycaemic control is strongly associated with lacunar infarction.",
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AU - Wan Yahya, Wan Nur Nafisah

AU - Sahathevan, Ramesh

AU - Hing, Jee Yong

AU - Zakaria, Mohd Firdaus

AU - Mohd Shuhari, Nurul Munirah

AU - Ahmad, Nur Fathihah

AU - Ting, Teong Kui

AU - Tan, Hui Jan

AU - Md. Rani, Shahrul Azmin

AU - Remli, Rabani

AU - Mohammed Nawi, Azmawati

AU - Mohamed Ibrahim, Norlinah

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