Hibiscus sabdariffa (Roselle) polyphenol-rich extract prevents the aortic oxidative damage in type 1 diabetic rats

Nur Liyana Mohammed Yusof, Fatin Farhana Jubaidi, Sharifah Niza Mohamad Nasir, Nur Afizah Yusoff, Norsyahida Mohd Fauzi, Satirah Zainalabidin, Siti Balkis Budin

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2 Citations (Scopus)

Abstract

Diabetes mellitus complications mainly occur due to the oxidative stress-related condition. Thus, this study aimed to investigate the protective effect of the polyphenol-rich extract of Hibiscus sabdariffa (roselle) (HPE) on the aorta of streptozotocin-induced diabetic rats. Twenty-four male Sprague-Dawley rats were divided into four groups (n=6/group); non-diabetes control (NDM), diabetes (DM), diabetes treated with HPE (DM+HPE) and metformin (DM+MET). HPE and metformin were given via oral force-feeding at the dose of 100mg/kg and 150mg/kg respectively for eight weeks duration. At the end of the experiment period, blood pressure was measured before the rats were sacrificed. Blood was taken for experimental of plasma glucose and lipid levels whilst aorta was excised for oxidative stress and histological evaluation. Results showed that HPE treatment reduced plasma glucose level, blood pressure and improved dyslipidemia significantly (p<0.05) in DM+HPE group compared to DM group. Malondialdehyde (MDA) and advanced oxidation protein product (AOPP) levels were significantly decreased (p<0.05) while reduced glutathione (GSH) level was significantly increased (p<0.05) in DM+HPE group compared to DM group. No histological changes observed in the aorta of all diabetic groups compared to NDM group. In conclusion, HPE might have a potential in minimizing of vascular damage in diabetic conditions.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalJurnal Teknologi
Volume80
Issue number2
DOIs
Publication statusPublished - 1 Mar 2018

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Medical problems
Rats
Oxidative stress
Blood pressure
Glucose
Plasmas
Lipids
Blood
Proteins
Oxidation
Polyphenols
Experiments

Keywords

  • Aorta
  • Diabetes mellitus
  • Dyslipidemia
  • Oxidative stress
  • Roselle

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Hibiscus sabdariffa (Roselle) polyphenol-rich extract prevents the aortic oxidative damage in type 1 diabetic rats. / Yusof, Nur Liyana Mohammed; Jubaidi, Fatin Farhana; Nasir, Sharifah Niza Mohamad; Yusoff, Nur Afizah; Mohd Fauzi, Norsyahida; Zainalabidin, Satirah; Budin, Siti Balkis.

In: Jurnal Teknologi, Vol. 80, No. 2, 01.03.2018, p. 1-8.

Research output: Contribution to journalArticle

Yusof, Nur Liyana Mohammed ; Jubaidi, Fatin Farhana ; Nasir, Sharifah Niza Mohamad ; Yusoff, Nur Afizah ; Mohd Fauzi, Norsyahida ; Zainalabidin, Satirah ; Budin, Siti Balkis. / Hibiscus sabdariffa (Roselle) polyphenol-rich extract prevents the aortic oxidative damage in type 1 diabetic rats. In: Jurnal Teknologi. 2018 ; Vol. 80, No. 2. pp. 1-8.
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