Hibiscus sabdariffa Linn. (Roselle) protects against nicotine-induced heart damage in rats

Satirah Zainalabidin, Siti Nor Farhanah Sh Nor Shahidin, Siti Balkis Budin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Nicotine has been identified as one of the causal factor for oxidative stress, hypertension and hyperlipidemia. Roselle has been widely studied for its potential as an antioxidant, antihyperlipidemic and antihypertensive. However, no studies have been done to investigate if roselle could diminish the oxidative stress caused by nicotine which could further lead to cardiac damages. Thus, this study was aimed to investigate the effect of roselle extract (HSE) on blood pressure, serum lipid profile, oxidative stress marker levels and histological changes to the heart in nicotine-treated rats. A total of 21 Sprague-Dawley rats were randomly divided into 3 groups (n=7 per group): Control group received normal saline (0.5 mL/day, i.p); nicotine group received 0.6 mg/kg/BW nicotine (i.p); and treated group received 100 mg/kg/b.w HSE through oral force feeding followed with 0.6 mg/kg/b.w nicotine (i.p) for 21 consecutive days. The results showed that HSE significantly (p>0.05) reduced the heart rate but no effect to the blood pressure. For lipid profile study, HSE increased the high-density lipoprotein (HDL) concentration significantly (p

Original languageEnglish
Pages (from-to)207-214
Number of pages8
JournalSains Malaysiana
Volume45
Issue number2
Publication statusPublished - 1 Feb 2016

Fingerprint

Hibiscus
Nicotine
Oxidative Stress
Blood Pressure
Lipids
Hypolipidemic Agents
Enteral Nutrition
HDL Lipoproteins
Hyperlipidemias
Antihypertensive Agents
Sprague Dawley Rats
Antioxidants
Heart Rate
Hypertension
Control Groups
Serum

Keywords

  • Blood pressure
  • Nicotine
  • Oxidative stress
  • Roselle

ASJC Scopus subject areas

  • General

Cite this

Hibiscus sabdariffa Linn. (Roselle) protects against nicotine-induced heart damage in rats. / Zainalabidin, Satirah; Shahidin, Siti Nor Farhanah Sh Nor; Budin, Siti Balkis.

In: Sains Malaysiana, Vol. 45, No. 2, 01.02.2016, p. 207-214.

Research output: Contribution to journalArticle

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