Hibiscus sabdariffa Linn. improves the aortic damage in diabetic rats by acting as antioxidant

Satirah Zainalabidin, Siti Balkis Budin, Nur Najmi Mohamad Anuar, Nur Afizah Yusoff, Nur Liyana Mohammed Yusof

Research output: Contribution to journalArticle

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Abstract

Chronic hyperglycaemia produces excessive free radicals which could lead to diabetic complications. Hibiscus sabdariffa Linn. is proven to have high antioxidant and antihyperlipidemic properties. The aim of the study was to investigate the effects of H. sabdariffa polyphenol-rich extract (HPE) in the aorta of diabetic rats. Twenty-four male rats were randomly divided into three groups, i.e. non-diabetes mellitus (NDM), diabetes mellitus (DM) and diabetes mellitus with HPE (DM + HPE). HPE at 100 mg/kg or saline as control vehicle were administered daily through oral gavage for 28 days prior to sacrification and the aorta was isolated for further analysis. The glucose level in DM + HPE was significantly lower compared to DM, indicating its potential as an antidiabetic agent. Conversely, catalase (CAT), superoxide dismutase (SOD) activity and the level of glutathione (GSH) in DM + HPE were significantly higher than DM. The level of malondialdehyde (MDA) and protein carbonyl were significantly lower in DM + HPE than DM. Lipid profile analysis demonstrated a significant decrease in triglyceride, total cholesterol and LDL-C in DM + HPE compared to DM, however, HDL-C was significantly increased. Microscopic observation showed a disrupted morphology of the thoracic aorta in diabetic rats. HPE may exert protective effects by acting as an antidiabetic, antihyperlipidemic and antioxidant agent to the thoracic aorta in diabetic rats.

Original languageEnglish
Pages (from-to)108-114
Number of pages7
JournalJournal of Applied Pharmaceutical Science
Volume8
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Hibiscus
Polyphenols
Diabetes Mellitus
Antioxidants
Hypolipidemic Agents
Thoracic Aorta
Hypoglycemic Agents
Aorta
Diabetes Complications
Malondialdehyde
Hyperglycemia
Catalase
Superoxide Dismutase
Free Radicals
Glutathione
Triglycerides

Keywords

  • Antioxidant
  • Diabetes
  • Free radical
  • Hibiscus sabdariffa Linn.
  • Oxidative damage

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

Hibiscus sabdariffa Linn. improves the aortic damage in diabetic rats by acting as antioxidant. / Zainalabidin, Satirah; Budin, Siti Balkis; Mohamad Anuar, Nur Najmi; Yusoff, Nur Afizah; Yusof, Nur Liyana Mohammed.

In: Journal of Applied Pharmaceutical Science, Vol. 8, No. 1, 01.01.2018, p. 108-114.

Research output: Contribution to journalArticle

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