Herbs for effective treatment of diabetes mellitus wounds: Medicinal chemistry and future therapeutic options

Khin Pa Pa Hlaing @ Farida Hussan, Mohamad Fairuz Yahaya, Seong Lin Teoh, Srijit Das

Research output: Contribution to journalReview article

Abstract

The incidence of diabetes mellitus (DM) has increased globally. Various complications such as blindness, nephropathy leading to renal failure, neuropathy, foot ulceration, amputation, and disturbance in autonomic nervous system were reported. Although, allopathy treatment still remains the treatment of choice, there is a need to look at the easy availability, patient compliance and cheaper cost of the drugs used in day-day practice. In this regard, complementary and alternative medicine has a greater role to play. Numerous plant extracts were shown to exhibit antihyperglycemic properties. In the present review, we surfed published literature in Pubmed and google databases with regard to the herbs used for DM wound treatment. We also discuss the possible mechanism of wound healing in DM with regard to advanced glycation end products, inflammation, macrophages, non-leukocytic cells such as keratinocytes, fibroblasts and endothelial cells, matrix metalloproteinase and miRNA. The review opens the door for effective treatment of DM wounds with plant extracts and plan future treatment options.

Original languageEnglish
Pages (from-to)697-710
Number of pages14
JournalMini-Reviews in Medicinal Chemistry
Volume18
Issue number8
DOIs
Publication statusPublished - 1 Jan 2018

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Pharmaceutical Chemistry
Diabetes Mellitus
Wounds and Injuries
Plant Extracts
Complementary Therapies
Therapeutics
Advanced Glycosylation End Products
Drug Costs
Autonomic Nervous System
Blindness
Patient Compliance
Matrix Metalloproteinases
MicroRNAs
Keratinocytes
Amputation
Hypoglycemic Agents
PubMed
Wound Healing
Renal Insufficiency
Foot

Keywords

  • Angiogenesis
  • Diabetes mellitus
  • Healing
  • Herb
  • Insulin
  • Macrophage
  • Wound

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Herbs for effective treatment of diabetes mellitus wounds : Medicinal chemistry and future therapeutic options. / Pa Pa Hlaing @ Farida Hussan, Khin; Yahaya, Mohamad Fairuz; Teoh, Seong Lin; Das, Srijit.

In: Mini-Reviews in Medicinal Chemistry, Vol. 18, No. 8, 01.01.2018, p. 697-710.

Research output: Contribution to journalReview article

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