Hepatocyte nuclear factor 4 alpha P2 promoter variants associate with insulin resistance

Riyadh Saif-Ali, Roslan Harun, S. Al-Jassabi, Wan Zurinah Wan Ngah

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    This study aimed to investigate the associations of hepatocyte nuclear factor 4 (HNF4) alpha single nucleotide polymorphisms (SNPs) and haplotype with insulin resistance and metabolic syndrome parameters. Nine SNPs spanning the HNF4 alpha P2 promoter (rs4810424, rs1884613 and rs1884614) and coding region (rs2144908, rs6031551, rs6031552, rs1885088, rs1028583 and rs3818247) were genotyped in 160 subjects without diabetes or metabolic syndrome. The HNF4 alpha P2 promoter SNPs rs4810424, rs1884613 and rs1884614 were associated with insulin resistance (p = 0.017; 0.037; 0.024) and body mass index (BMI) (p = 0.03; 0.035; 0.039). The intron 1D SNP rs2144908 was associated with highdensity lipoprotein cholesterol (HDLc) (p = 0.020) and the intron 9 SNP rs3818247 showed association with systolic (p = 0.02) and diastolic (p = 0.034) blood pressure. HNF4 alpha common haplotype CCCGTC associated with higher insulin resistance (p = 0.022), fasting blood glucose (FBG) (p = 0.035) and lower HDLc (p = 0.001). In conclusion, subjects with HNF4 alpha P2 variants and haplotypes have been shown to have a higher insulin resistance and are therefore at a higher risk for developing type 2 diabetes mellitus.

    Original languageEnglish
    Pages (from-to)179-186
    Number of pages8
    JournalActa Biochimica Polonica
    Volume58
    Issue number2
    Publication statusPublished - 2011

    Fingerprint

    Hepatocyte Nuclear Factor 4
    Polymorphism
    Single Nucleotide Polymorphism
    Insulin Resistance
    Nucleotides
    Insulin
    Haplotypes
    Medical problems
    Introns
    Blood pressure
    Type 2 Diabetes Mellitus
    Blood Glucose
    Fasting
    Body Mass Index
    Blood Pressure

    Keywords

    • Haplotypes
    • HNF4 alpha
    • Insulin resistance
    • Single nucleotide polymorphisms

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Saif-Ali, R., Harun, R., Al-Jassabi, S., & Ngah, W. Z. W. (2011). Hepatocyte nuclear factor 4 alpha P2 promoter variants associate with insulin resistance. Acta Biochimica Polonica, 58(2), 179-186.

    Hepatocyte nuclear factor 4 alpha P2 promoter variants associate with insulin resistance. / Saif-Ali, Riyadh; Harun, Roslan; Al-Jassabi, S.; Ngah, Wan Zurinah Wan.

    In: Acta Biochimica Polonica, Vol. 58, No. 2, 2011, p. 179-186.

    Research output: Contribution to journalArticle

    Saif-Ali, R, Harun, R, Al-Jassabi, S & Ngah, WZW 2011, 'Hepatocyte nuclear factor 4 alpha P2 promoter variants associate with insulin resistance', Acta Biochimica Polonica, vol. 58, no. 2, pp. 179-186.
    Saif-Ali, Riyadh ; Harun, Roslan ; Al-Jassabi, S. ; Ngah, Wan Zurinah Wan. / Hepatocyte nuclear factor 4 alpha P2 promoter variants associate with insulin resistance. In: Acta Biochimica Polonica. 2011 ; Vol. 58, No. 2. pp. 179-186.
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