Hepatocyte death following transforming growth factor-β1 addition

Franziska Oberhammer, Gertraud Froschl, Roman Tiefenbacher, Salmaan H. Inayat-Hussain, Kelvin Cain, Helga Stopper

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Apoptosis is a morphological term which describes a sequence of events finally leading to cell death. In epithelial organs, induction of cell death is closely linked to an inhibitor of epithelial growth, transforming growth factor-β1 (TGF-β1). In this paper, we describe the morphology of TGF-β1- induced apoptosis in hepatocytes of the hyperplastic liver and primary cultures. Chromatin condensation, a hallmark of apoptosis, was observed in primary hepatocytes by confocal and vital UV microscopy. In addition, we have applied the morphological detection of DNA strand breaks both by in situ tailing (ISTAIL) and in situ nick translation (ISNT).

Original languageEnglish
Pages (from-to)247-258
Number of pages12
JournalMicroscopy Research and Technique
Volume34
Issue number3
DOIs
Publication statusPublished - 1996
Externally publishedYes

Fingerprint

transforming growth factors
apoptosis
Transforming Growth Factors
Cell death
death
hepatocytes
Hepatocytes
Apoptosis
cell death
Cell Death
Growth Inhibitors
chromatin
DNA Breaks
liver
organs
strands
inhibitors
translation (genetics)
Chromatin
Microscopy

Keywords

  • Apoptosis
  • Hepatocyte
  • Hyperplastic liver
  • In situ tailing
  • Transforming growth factor-β1

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Anatomy
  • Instrumentation

Cite this

Oberhammer, F., Froschl, G., Tiefenbacher, R., Inayat-Hussain, S. H., Cain, K., & Stopper, H. (1996). Hepatocyte death following transforming growth factor-β1 addition. Microscopy Research and Technique, 34(3), 247-258. https://doi.org/10.1002/(SICI)1097-0029(19960615)34:3<247::AID-JEMT7>3.0.CO;2-M

Hepatocyte death following transforming growth factor-β1 addition. / Oberhammer, Franziska; Froschl, Gertraud; Tiefenbacher, Roman; Inayat-Hussain, Salmaan H.; Cain, Kelvin; Stopper, Helga.

In: Microscopy Research and Technique, Vol. 34, No. 3, 1996, p. 247-258.

Research output: Contribution to journalArticle

Oberhammer, F, Froschl, G, Tiefenbacher, R, Inayat-Hussain, SH, Cain, K & Stopper, H 1996, 'Hepatocyte death following transforming growth factor-β1 addition', Microscopy Research and Technique, vol. 34, no. 3, pp. 247-258. https://doi.org/10.1002/(SICI)1097-0029(19960615)34:3<247::AID-JEMT7>3.0.CO;2-M
Oberhammer, Franziska ; Froschl, Gertraud ; Tiefenbacher, Roman ; Inayat-Hussain, Salmaan H. ; Cain, Kelvin ; Stopper, Helga. / Hepatocyte death following transforming growth factor-β1 addition. In: Microscopy Research and Technique. 1996 ; Vol. 34, No. 3. pp. 247-258.
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