Hepato-protective effects of pimpinella tirupatiensis extract on cytosolic and mitochondrial enzymes against streptozotocin (STZ) -injected pathogenic diabetic rats

Ganapathi Narasimhulu, Sathyavelu Reddy Kesireddy, Pasupuleti Visweswara Rao, Jamaludin Mohamed

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: The study was conducted to evaluate the anti hyperglycemic effect of P. tirupatiensis on altered blood glucose levels, water, food intake, cytosolic and mitochondrial enzymes in control and STZ- treated diabetic rats. Methods: The anti hyperglycemic effect of P. tirupatiensiswas determined by various methods like blood glucose levels, water, food intake, cytosolic and mitochondrial enzymes. Results: On oral administration of P. tirupatiensis at a dose of 0.750 g/kg body weight per day to diabetic rats for 30 days; resulted in a significant (p<0.01) reduction in the levels of blood glucose, water and food intake whereas a significantly (p<0.01) increase in the activities of hepatic cytosolic and mitochondrial marker enzymes such as glucose- 6-phosphate dehydrogenase (G6PD), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and glutamate dehydrogenase (GDH) along with significant (p<0.01) reduction in the activity of hepatic cytosolic enzyme lactate dehydrogenase (LDH) in diabetic treated rats. Furthermore, protection against body weight loss of diabetic animals also observed. Conclusion: In this study, we concluded that P. tirupatiensisextract could lower the blood glucose levels as well as improve activities of cytosolic and mitochondrial enzymes in streptozotocin (STZ) - injected pathogenic diabetic rats.

Original languageEnglish
Pages (from-to)792-797
Number of pages6
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume6
Issue numberSUPPL. 2
Publication statusPublished - 2014

Fingerprint

Pimpinella
Streptozocin
Blood Glucose
Drinking
Enzymes
Eating
Body Weight
Glutamate Dehydrogenase
Malate Dehydrogenase
Succinate Dehydrogenase
Glucosephosphate Dehydrogenase
Liver
L-Lactate Dehydrogenase
Oral Administration
Weight Loss

Keywords

  • Diabetes
  • Mitochondrial function markers
  • P. tirupatiensis
  • Rat

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Hepato-protective effects of pimpinella tirupatiensis extract on cytosolic and mitochondrial enzymes against streptozotocin (STZ) -injected pathogenic diabetic rats. / Narasimhulu, Ganapathi; Kesireddy, Sathyavelu Reddy; Rao, Pasupuleti Visweswara; Mohamed, Jamaludin.

In: International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, No. SUPPL. 2, 2014, p. 792-797.

Research output: Contribution to journalArticle

Narasimhulu, Ganapathi ; Kesireddy, Sathyavelu Reddy ; Rao, Pasupuleti Visweswara ; Mohamed, Jamaludin. / Hepato-protective effects of pimpinella tirupatiensis extract on cytosolic and mitochondrial enzymes against streptozotocin (STZ) -injected pathogenic diabetic rats. In: International Journal of Pharmacy and Pharmaceutical Sciences. 2014 ; Vol. 6, No. SUPPL. 2. pp. 792-797.
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AB - Objective: The study was conducted to evaluate the anti hyperglycemic effect of P. tirupatiensis on altered blood glucose levels, water, food intake, cytosolic and mitochondrial enzymes in control and STZ- treated diabetic rats. Methods: The anti hyperglycemic effect of P. tirupatiensiswas determined by various methods like blood glucose levels, water, food intake, cytosolic and mitochondrial enzymes. Results: On oral administration of P. tirupatiensis at a dose of 0.750 g/kg body weight per day to diabetic rats for 30 days; resulted in a significant (p<0.01) reduction in the levels of blood glucose, water and food intake whereas a significantly (p<0.01) increase in the activities of hepatic cytosolic and mitochondrial marker enzymes such as glucose- 6-phosphate dehydrogenase (G6PD), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and glutamate dehydrogenase (GDH) along with significant (p<0.01) reduction in the activity of hepatic cytosolic enzyme lactate dehydrogenase (LDH) in diabetic treated rats. Furthermore, protection against body weight loss of diabetic animals also observed. Conclusion: In this study, we concluded that P. tirupatiensisextract could lower the blood glucose levels as well as improve activities of cytosolic and mitochondrial enzymes in streptozotocin (STZ) - injected pathogenic diabetic rats.

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