Abstract
Objective: The study was conducted to evaluate the anti hyperglycemic effect of P. tirupatiensis on altered blood glucose levels, water, food intake, cytosolic and mitochondrial enzymes in control and STZ- treated diabetic rats. Methods: The anti hyperglycemic effect of P. tirupatiensiswas determined by various methods like blood glucose levels, water, food intake, cytosolic and mitochondrial enzymes. Results: On oral administration of P. tirupatiensis at a dose of 0.750 g/kg body weight per day to diabetic rats for 30 days; resulted in a significant (p<0.01) reduction in the levels of blood glucose, water and food intake whereas a significantly (p<0.01) increase in the activities of hepatic cytosolic and mitochondrial marker enzymes such as glucose- 6-phosphate dehydrogenase (G6PD), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and glutamate dehydrogenase (GDH) along with significant (p<0.01) reduction in the activity of hepatic cytosolic enzyme lactate dehydrogenase (LDH) in diabetic treated rats. Furthermore, protection against body weight loss of diabetic animals also observed. Conclusion: In this study, we concluded that P. tirupatiensisextract could lower the blood glucose levels as well as improve activities of cytosolic and mitochondrial enzymes in streptozotocin (STZ) - injected pathogenic diabetic rats.
| Original language | English |
|---|---|
| Pages (from-to) | 792-797 |
| Number of pages | 6 |
| Journal | International Journal of Pharmacy and Pharmaceutical Sciences |
| Volume | 6 |
| Issue number | SUPPL. 2 |
| Publication status | Published - 2014 |
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Keywords
- Diabetes
- Mitochondrial function markers
- P. tirupatiensis
- Rat
ASJC Scopus subject areas
- Pharmaceutical Science
- Pharmacology
Cite this
Hepato-protective effects of pimpinella tirupatiensis extract on cytosolic and mitochondrial enzymes against streptozotocin (STZ) -injected pathogenic diabetic rats. / Narasimhulu, Ganapathi; Kesireddy, Sathyavelu Reddy; Rao, Pasupuleti Visweswara; Mohamed, Jamaludin.
In: International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, No. SUPPL. 2, 2014, p. 792-797.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hepato-protective effects of pimpinella tirupatiensis extract on cytosolic and mitochondrial enzymes against streptozotocin (STZ) -injected pathogenic diabetic rats
AU - Narasimhulu, Ganapathi
AU - Kesireddy, Sathyavelu Reddy
AU - Rao, Pasupuleti Visweswara
AU - Mohamed, Jamaludin
PY - 2014
Y1 - 2014
N2 - Objective: The study was conducted to evaluate the anti hyperglycemic effect of P. tirupatiensis on altered blood glucose levels, water, food intake, cytosolic and mitochondrial enzymes in control and STZ- treated diabetic rats. Methods: The anti hyperglycemic effect of P. tirupatiensiswas determined by various methods like blood glucose levels, water, food intake, cytosolic and mitochondrial enzymes. Results: On oral administration of P. tirupatiensis at a dose of 0.750 g/kg body weight per day to diabetic rats for 30 days; resulted in a significant (p<0.01) reduction in the levels of blood glucose, water and food intake whereas a significantly (p<0.01) increase in the activities of hepatic cytosolic and mitochondrial marker enzymes such as glucose- 6-phosphate dehydrogenase (G6PD), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and glutamate dehydrogenase (GDH) along with significant (p<0.01) reduction in the activity of hepatic cytosolic enzyme lactate dehydrogenase (LDH) in diabetic treated rats. Furthermore, protection against body weight loss of diabetic animals also observed. Conclusion: In this study, we concluded that P. tirupatiensisextract could lower the blood glucose levels as well as improve activities of cytosolic and mitochondrial enzymes in streptozotocin (STZ) - injected pathogenic diabetic rats.
AB - Objective: The study was conducted to evaluate the anti hyperglycemic effect of P. tirupatiensis on altered blood glucose levels, water, food intake, cytosolic and mitochondrial enzymes in control and STZ- treated diabetic rats. Methods: The anti hyperglycemic effect of P. tirupatiensiswas determined by various methods like blood glucose levels, water, food intake, cytosolic and mitochondrial enzymes. Results: On oral administration of P. tirupatiensis at a dose of 0.750 g/kg body weight per day to diabetic rats for 30 days; resulted in a significant (p<0.01) reduction in the levels of blood glucose, water and food intake whereas a significantly (p<0.01) increase in the activities of hepatic cytosolic and mitochondrial marker enzymes such as glucose- 6-phosphate dehydrogenase (G6PD), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and glutamate dehydrogenase (GDH) along with significant (p<0.01) reduction in the activity of hepatic cytosolic enzyme lactate dehydrogenase (LDH) in diabetic treated rats. Furthermore, protection against body weight loss of diabetic animals also observed. Conclusion: In this study, we concluded that P. tirupatiensisextract could lower the blood glucose levels as well as improve activities of cytosolic and mitochondrial enzymes in streptozotocin (STZ) - injected pathogenic diabetic rats.
KW - Diabetes
KW - Mitochondrial function markers
KW - P. tirupatiensis
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=84896443038&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896443038&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84896443038
VL - 6
SP - 792
EP - 797
JO - International Journal of Pharmacy and Pharmaceutical Sciences
JF - International Journal of Pharmacy and Pharmaceutical Sciences
SN - 0975-1491
IS - SUPPL. 2
ER -