Hemoglobinopathies and thalassemia screening among Senoi Orang Asli in Peninsular Malaysia

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Orang Asli are the minority indigenous people in Peninsular Malaysia and can be divided into 3 main groups (Negrito, Senoi and Proto Malay) with different six sub-ethnics under each group. Within the Senoi group, the six sub-ethnics are sub-ethnic Mah Meri, Semoq Beri, Che Wong, Jah Hut, Semai and Temiar. This study was aimed to investigate the current prevalence of α- and β-thalassemia and hemoglobinopathies and their mutation types among all six sub-ethnics of Senoi Orang Asli. Blood samples from 685 Senoi participants were collected and sent immediately for routine full blood count analysis and hemoglobin sub-typing. Of 378 subjects screened, 7 subjects were found to be Hemoglobin E (HbE) beta thalassemia carriers, 13 beta thalassaemic, 35 Hemoglobin Constant Spring (HbCS) carriers, 6 compound HbE and HbCS carriers, 32 with HbE disease and 163 HbE heterozygote carriers. The findings of high HbE among Temiars and Jah Huts and high HbCS exclusively in Jah Huts in this study suggest distinct differences across sub-ethnics under Senoi group. Understanding of prevalence and wide spectrum of thalassemia and hemoglobinopathies among Senoi and Orang Asli is essential for national thalassaemia awareness and prevention program, especially in Orang Asli communities.

Original languageEnglish
Title of host publicationAIP Conference Proceedings
PublisherAmerican Institute of Physics Inc.
Volume1678
ISBN (Print)9780735413252
DOIs
Publication statusPublished - 25 Sep 2015
Event2015 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2015 - Selangor, Malaysia
Duration: 15 Apr 201516 Apr 2015

Other

Other2015 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2015
CountryMalaysia
CitySelangor
Period15/4/1516/4/15

Fingerprint

Malaysia
hemoglobin
screening
blood
minorities
mutations

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Rong, D. K. X., Ismail, E., Raja Sabudin, R. Z. A., Hussin, N. H., & Othman, A. (2015). Hemoglobinopathies and thalassemia screening among Senoi Orang Asli in Peninsular Malaysia. In AIP Conference Proceedings (Vol. 1678). [030033] American Institute of Physics Inc.. https://doi.org/10.1063/1.4931254

Hemoglobinopathies and thalassemia screening among Senoi Orang Asli in Peninsular Malaysia. / Rong, Danny Koh Xuan; Ismail, Endom; Raja Sabudin, Raja Zahratul Azma; Hussin, Noor Hamidah; Othman, Ainoon.

AIP Conference Proceedings. Vol. 1678 American Institute of Physics Inc., 2015. 030033.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Rong, DKX, Ismail, E, Raja Sabudin, RZA, Hussin, NH & Othman, A 2015, Hemoglobinopathies and thalassemia screening among Senoi Orang Asli in Peninsular Malaysia. in AIP Conference Proceedings. vol. 1678, 030033, American Institute of Physics Inc., 2015 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2015, Selangor, Malaysia, 15/4/15. https://doi.org/10.1063/1.4931254
Rong DKX, Ismail E, Raja Sabudin RZA, Hussin NH, Othman A. Hemoglobinopathies and thalassemia screening among Senoi Orang Asli in Peninsular Malaysia. In AIP Conference Proceedings. Vol. 1678. American Institute of Physics Inc. 2015. 030033 https://doi.org/10.1063/1.4931254
Rong, Danny Koh Xuan ; Ismail, Endom ; Raja Sabudin, Raja Zahratul Azma ; Hussin, Noor Hamidah ; Othman, Ainoon. / Hemoglobinopathies and thalassemia screening among Senoi Orang Asli in Peninsular Malaysia. AIP Conference Proceedings. Vol. 1678 American Institute of Physics Inc., 2015.
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