Hematological studies in young individuals with Down syndrome

Maziana Mahamood, Mizaton Hazizul Hasan, Mohd Alimukhti, Caroline Sunggip, Alini Marzuki, Wan Zurinah Wan Ngah, Aishah Adam

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Down syndrome (DS) is a common chromosomal abnormality occurring in about 1 in 700 live births. One of the major medical problems in DS individuals is hematologic abnormalities. This study was carried out to compare the hematological status in young individuals with DS aged 5 to 20 years old (divided into three different age groups: 1 to 7 years [n=7], 8 to 12 years [n=49] and 13 to 20 years [n=50]) and in comparison to age-matched controls and also between genders. Blood samples were collected with informed consent from 106 DS participants and another 106 controls. The blood count was evaluated by blood analyzer (Coulter T-540). There were significantly lower levels of red blood cell count in DS females than in males at the ages of 13 to 20 years (p=0.011). Hemoglobin levels in DS females were significantly lower in the age of 13 to 20 years (p=0.016). A significantly lower hematocrit level was observed in DS females at the age of 13 to 20 years (p=0.005). The mean of white blood cells count in DS was significantly lower than in controls at the ages of 1 to 7 years (p=0.014) and 8 to 12 years (p=0.021). The granulocyte levels was significantly lower in DS by about 45% than in controls aged 8 to 12 years (p=0.038) and also in DS females, aged 13 to 20 years as compared to males (p=0.04). These findings indicate that DS individuals experience hematologic abnormalities and further study should be conducted in order to understand the significance of the abnormalities.

    Original languageEnglish
    Title of host publicationIECBES 2014, Conference Proceedings - 2014 IEEE Conference on Biomedical Engineering and Sciences: "Miri, Where Engineering in Medicine and Biology and Humanity Meet"
    PublisherInstitute of Electrical and Electronics Engineers Inc.
    Pages419-423
    Number of pages5
    ISBN (Print)9781479940844
    DOIs
    Publication statusPublished - 23 Feb 2015
    Event3rd IEEE Conference on Biomedical Engineering and Sciences, IECBES 2014 - Kuala Lumpur
    Duration: 8 Dec 201410 Dec 2014

    Other

    Other3rd IEEE Conference on Biomedical Engineering and Sciences, IECBES 2014
    CityKuala Lumpur
    Period8/12/1410/12/14

    Fingerprint

    Blood
    Cells
    Hemoglobin
    Medical problems

    ASJC Scopus subject areas

    • Biomedical Engineering

    Cite this

    Mahamood, M., Hasan, M. H., Alimukhti, M., Sunggip, C., Marzuki, A., Ngah, W. Z. W., & Adam, A. (2015). Hematological studies in young individuals with Down syndrome. In IECBES 2014, Conference Proceedings - 2014 IEEE Conference on Biomedical Engineering and Sciences: "Miri, Where Engineering in Medicine and Biology and Humanity Meet" (pp. 419-423). [7047533] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/IECBES.2014.7047533

    Hematological studies in young individuals with Down syndrome. / Mahamood, Maziana; Hasan, Mizaton Hazizul; Alimukhti, Mohd; Sunggip, Caroline; Marzuki, Alini; Ngah, Wan Zurinah Wan; Adam, Aishah.

    IECBES 2014, Conference Proceedings - 2014 IEEE Conference on Biomedical Engineering and Sciences: "Miri, Where Engineering in Medicine and Biology and Humanity Meet". Institute of Electrical and Electronics Engineers Inc., 2015. p. 419-423 7047533.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Mahamood, M, Hasan, MH, Alimukhti, M, Sunggip, C, Marzuki, A, Ngah, WZW & Adam, A 2015, Hematological studies in young individuals with Down syndrome. in IECBES 2014, Conference Proceedings - 2014 IEEE Conference on Biomedical Engineering and Sciences: "Miri, Where Engineering in Medicine and Biology and Humanity Meet"., 7047533, Institute of Electrical and Electronics Engineers Inc., pp. 419-423, 3rd IEEE Conference on Biomedical Engineering and Sciences, IECBES 2014, Kuala Lumpur, 8/12/14. https://doi.org/10.1109/IECBES.2014.7047533
    Mahamood M, Hasan MH, Alimukhti M, Sunggip C, Marzuki A, Ngah WZW et al. Hematological studies in young individuals with Down syndrome. In IECBES 2014, Conference Proceedings - 2014 IEEE Conference on Biomedical Engineering and Sciences: "Miri, Where Engineering in Medicine and Biology and Humanity Meet". Institute of Electrical and Electronics Engineers Inc. 2015. p. 419-423. 7047533 https://doi.org/10.1109/IECBES.2014.7047533
    Mahamood, Maziana ; Hasan, Mizaton Hazizul ; Alimukhti, Mohd ; Sunggip, Caroline ; Marzuki, Alini ; Ngah, Wan Zurinah Wan ; Adam, Aishah. / Hematological studies in young individuals with Down syndrome. IECBES 2014, Conference Proceedings - 2014 IEEE Conference on Biomedical Engineering and Sciences: "Miri, Where Engineering in Medicine and Biology and Humanity Meet". Institute of Electrical and Electronics Engineers Inc., 2015. pp. 419-423
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