Helicobacter pylori infection is associated with worse severity of Parkinson's disease

Ai Huey Tan, Sanjiv Mahadeva, Connie Marras, Abdul Malik Thalha, Chiun Khang Kiew, Chia Ming Yeat, Sheang Wen Ng, Sheau Phing Ang, Siew Kian Chow, Mun Fai Loke, Jamunarani S. Vadivelu, Norlinah Mohamed Ibrahim, Hoi Sen Yong, Chong Tin Tan, Susan H. Fox, Anthony E. Lang, Shen Yang Lim

Research output: Contribution to journalArticle

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Abstract

Background: Some studies have suggested that chronic Helicobacter pylori (HP) infection can aggravate the neurodegenerative process in Parkinson's disease (PD), and targeted intervention could potentially modify the course of this disabling disease. We aimed to study the impact of HP infection on motor function, gastrointestinal symptoms, and quality of life in a large cohort of PD patients. Methods: 102 consecutive PD patients underwent 13C urea breath testing and blinded evaluations consisting of the Unified Parkinson's Disease Rating Scale (UPDRS) including "On"-medication motor examination (Part III), objective and quantitative measures of bradykinesia (Purdue Pegboard and timed gait), Leeds Dyspepsia Questionnaire, and PDQ-39 (a health-related quality of life questionnaire). Results: 32.4% of PD patients were HP-positive. HP-positive patients were older (68.4±7.3 vs. 63.8±8.6 years, P=0.009) and had worse motor function (UPDRS Part III 34.0±13.0 vs. 27.3±10.0, P=0.04; Pegboard 6.4±3.3 vs. 8.0±2.7 pins, P=0.04; and timed gait 25.1±25.4 vs. 15.5±7.6s, P=0.08). In the multivariate analysis, HP status demonstrated significant main effects on UPDRS Part III and timed gait. The association between HP status and these motor outcomes varied according to age. Gastrointestinal symptoms and PDQ-39 Summary Index scores did not differ between the two groups. Conclusions: This is the largest cross-sectional study to demonstrate an association between HP positivity and worse PD motor severity.

Original languageEnglish
Pages (from-to)221-225
Number of pages5
JournalParkinsonism and Related Disorders
Volume21
Issue number3
DOIs
Publication statusPublished - 1 Mar 2015

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Helicobacter Infections
Helicobacter pylori
Parkinson Disease
Gait
Quality of Life
Hypokinesia
Dyspepsia
Urea
Multivariate Analysis
Cross-Sectional Studies

Keywords

  • Gastrointestinal dysfunction
  • Helicobacter pylori
  • Parkinson's disease

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology

Cite this

Tan, A. H., Mahadeva, S., Marras, C., Thalha, A. M., Kiew, C. K., Yeat, C. M., ... Lim, S. Y. (2015). Helicobacter pylori infection is associated with worse severity of Parkinson's disease. Parkinsonism and Related Disorders, 21(3), 221-225. https://doi.org/10.1016/j.parkreldis.2014.12.009

Helicobacter pylori infection is associated with worse severity of Parkinson's disease. / Tan, Ai Huey; Mahadeva, Sanjiv; Marras, Connie; Thalha, Abdul Malik; Kiew, Chiun Khang; Yeat, Chia Ming; Ng, Sheang Wen; Ang, Sheau Phing; Chow, Siew Kian; Loke, Mun Fai; Vadivelu, Jamunarani S.; Mohamed Ibrahim, Norlinah; Yong, Hoi Sen; Tan, Chong Tin; Fox, Susan H.; Lang, Anthony E.; Lim, Shen Yang.

In: Parkinsonism and Related Disorders, Vol. 21, No. 3, 01.03.2015, p. 221-225.

Research output: Contribution to journalArticle

Tan, AH, Mahadeva, S, Marras, C, Thalha, AM, Kiew, CK, Yeat, CM, Ng, SW, Ang, SP, Chow, SK, Loke, MF, Vadivelu, JS, Mohamed Ibrahim, N, Yong, HS, Tan, CT, Fox, SH, Lang, AE & Lim, SY 2015, 'Helicobacter pylori infection is associated with worse severity of Parkinson's disease', Parkinsonism and Related Disorders, vol. 21, no. 3, pp. 221-225. https://doi.org/10.1016/j.parkreldis.2014.12.009
Tan, Ai Huey ; Mahadeva, Sanjiv ; Marras, Connie ; Thalha, Abdul Malik ; Kiew, Chiun Khang ; Yeat, Chia Ming ; Ng, Sheang Wen ; Ang, Sheau Phing ; Chow, Siew Kian ; Loke, Mun Fai ; Vadivelu, Jamunarani S. ; Mohamed Ibrahim, Norlinah ; Yong, Hoi Sen ; Tan, Chong Tin ; Fox, Susan H. ; Lang, Anthony E. ; Lim, Shen Yang. / Helicobacter pylori infection is associated with worse severity of Parkinson's disease. In: Parkinsonism and Related Disorders. 2015 ; Vol. 21, No. 3. pp. 221-225.
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AU - Tan, Ai Huey

AU - Mahadeva, Sanjiv

AU - Marras, Connie

AU - Thalha, Abdul Malik

AU - Kiew, Chiun Khang

AU - Yeat, Chia Ming

AU - Ng, Sheang Wen

AU - Ang, Sheau Phing

AU - Chow, Siew Kian

AU - Loke, Mun Fai

AU - Vadivelu, Jamunarani S.

AU - Mohamed Ibrahim, Norlinah

AU - Yong, Hoi Sen

AU - Tan, Chong Tin

AU - Fox, Susan H.

AU - Lang, Anthony E.

AU - Lim, Shen Yang

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Background: Some studies have suggested that chronic Helicobacter pylori (HP) infection can aggravate the neurodegenerative process in Parkinson's disease (PD), and targeted intervention could potentially modify the course of this disabling disease. We aimed to study the impact of HP infection on motor function, gastrointestinal symptoms, and quality of life in a large cohort of PD patients. Methods: 102 consecutive PD patients underwent 13C urea breath testing and blinded evaluations consisting of the Unified Parkinson's Disease Rating Scale (UPDRS) including "On"-medication motor examination (Part III), objective and quantitative measures of bradykinesia (Purdue Pegboard and timed gait), Leeds Dyspepsia Questionnaire, and PDQ-39 (a health-related quality of life questionnaire). Results: 32.4% of PD patients were HP-positive. HP-positive patients were older (68.4±7.3 vs. 63.8±8.6 years, P=0.009) and had worse motor function (UPDRS Part III 34.0±13.0 vs. 27.3±10.0, P=0.04; Pegboard 6.4±3.3 vs. 8.0±2.7 pins, P=0.04; and timed gait 25.1±25.4 vs. 15.5±7.6s, P=0.08). In the multivariate analysis, HP status demonstrated significant main effects on UPDRS Part III and timed gait. The association between HP status and these motor outcomes varied according to age. Gastrointestinal symptoms and PDQ-39 Summary Index scores did not differ between the two groups. Conclusions: This is the largest cross-sectional study to demonstrate an association between HP positivity and worse PD motor severity.

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