Helicobacter pylori cagA gene variants in Malaysians of different ethnicity

Ramelah Mohamed, Alfizah Hanafiah, Isa M. Rose, Mohd Rizal Abdul Manaf, Shiekh Anwar Abdullah, Ismail Sagap, A. Van Belkum, Jasmi A. Yaacob

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We have defined DNA repeat variability in the 3?-terminus of the cagA gene of Helicobacter pylori strains from Malaysian patients of different ethnicities. We identified different alleles based on the EPIYA repeats. cagA types A-B-D and A-B-B-D are more similar to the sequence of Japanese strains, whereas cagA types A-B-C, A-B-C-C, A-B and A-C displayed similarity to strain 26695 sequences. A significant association was found between cagA genotypes and patients' ethnicity, with cagA type A-B-D being predominantly isolated from Chinese patients and cagA type A-B-C from Malays and Indians. Our data further corroborate the possibility that variant biological activity of CagA may affect the host specificity and/or pathogenicity of H. pylori.

Original languageEnglish
Pages (from-to)865-869
Number of pages5
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume28
Issue number7
DOIs
Publication statusPublished - Jul 2009

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Helicobacter pylori
Genes
Host Specificity
Virulence
Alleles
Genotype
DNA

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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Helicobacter pylori cagA gene variants in Malaysians of different ethnicity. / Mohamed, Ramelah; Hanafiah, Alfizah; Rose, Isa M.; Abdul Manaf, Mohd Rizal; Abdullah, Shiekh Anwar; Sagap, Ismail; Van Belkum, A.; Yaacob, Jasmi A.

In: European Journal of Clinical Microbiology and Infectious Diseases, Vol. 28, No. 7, 07.2009, p. 865-869.

Research output: Contribution to journalArticle

Mohamed, Ramelah ; Hanafiah, Alfizah ; Rose, Isa M. ; Abdul Manaf, Mohd Rizal ; Abdullah, Shiekh Anwar ; Sagap, Ismail ; Van Belkum, A. ; Yaacob, Jasmi A. / Helicobacter pylori cagA gene variants in Malaysians of different ethnicity. In: European Journal of Clinical Microbiology and Infectious Diseases. 2009 ; Vol. 28, No. 7. pp. 865-869.
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