Healthy eating index and breast cancer risk among Malaysian women

Mohd Razif Shahril, Suhaina Sulaiman, Soraya Hanie Shaharudin, Sharifah Noor Akmal

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Healthy Eating Index-2005 (HEI-2005), an index-based dietary pattern, has been shown to predict the risk of chronic diseases among Americans. This study aims to examine the ability of HEI-2005 in predicting the probability for risk of premenopausal and postmenopausal breast cancer among Malaysian women. Data from a case-control nutritional epidemiology study among 764 participants including 382 breast cancer cases and 382 healthy women were extracted and scored. Multivariate odds ratios (OR) with 95% confidence intervals (CI) were used to evaluate the relationship between the risk of breast cancer and quartiles (Q) of HEI-2005 total scores and its component, whereas the risk prediction ability of HEI-2005 was investigated using diagnostics analysis. The results of this study showed that there is a significant reduction in the risk of breast cancer, with a higher HEI-2005 total score among premenopausal women (OR Q1 vs. Q4=0.34, 95% CI; 0.15-0.76) and postmenopausal women (OR Q1 vs. Q4=0.20, 95% CI; 0.06-0.63). However, HEI-2005 has a sensitivity of 56-60%, a specificity of 55-60%, and a positive predictive value and negative predictive value of 57-58%, which indicates a moderate ability to predict the risk of breast cancer according to menopausal status. The breast cancer incidence observed poorly agrees with risk outcomes from HEI-2005 as shown by low κ statistics (κ=0.15). In conclusion, although the total HEI-2005 scores were associated with a risk of breast cancer among Malaysian women, the ability of HEI-2005 to predict risk is poor as indicated by the diagnostic analysis. A local index-based dietary pattern, which is disease specific, is required to predict the risk of breast cancer among Malaysian women for early prevention.

Original languageEnglish
Pages (from-to)342-347
Number of pages6
JournalEuropean Journal of Cancer Prevention
Volume22
Issue number4
DOIs
Publication statusPublished - Jul 2013

Fingerprint

Breast Neoplasms
Aptitude
Odds Ratio
Confidence Intervals
Healthy Diet
Risk Reduction Behavior
Epidemiology
Chronic Disease
Incidence

Keywords

  • breast cancer
  • dietary screening
  • healthy eating index
  • risk assessment

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Healthy eating index and breast cancer risk among Malaysian women. / Shahril, Mohd Razif; Sulaiman, Suhaina; Shaharudin, Soraya Hanie; Akmal, Sharifah Noor.

In: European Journal of Cancer Prevention, Vol. 22, No. 4, 07.2013, p. 342-347.

Research output: Contribution to journalArticle

Shahril, Mohd Razif ; Sulaiman, Suhaina ; Shaharudin, Soraya Hanie ; Akmal, Sharifah Noor. / Healthy eating index and breast cancer risk among Malaysian women. In: European Journal of Cancer Prevention. 2013 ; Vol. 22, No. 4. pp. 342-347.
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