Health related quality of life of dialysis patients in Malaysia: Haemodialysis versus continuous ambulatory peritoneal dialysis

Naren Kumar Surendra, Mohd Rizal Abdul Manaf, Lai Seong Hooi, Sunita Bavanandan, Fariz Safhan Mohamad Nor, Shahnaz Shah Firdaus Khan, Loke Meng Ong, Abdul Halim Abdul Gafor

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Health related quality of life (HRQOL) is an important predictor of clinical outcomes for End Stage Renal Disease (ESRD) patients and to establish quality adjusted life years (QALYs) for economic evaluation studies. This study aims to measure the health utilities and to identify socio-demographic and clinical factors associated with HRQOL for haemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) in Malaysia. Methods: A total of 141 patients (77 HD and 64 CAPD) from 1 federal and four state hospitals participated in this cross-sectional study. Patients were randomly selected from the National Renal Registry (NRR) using a stratified random sampling. The EQ-5D-3 L questionnaire was used to measure HRQOL. Variables investigated include dialysis modalities, sociodemographic characteristics, co-morbidities and biochemical markers. Utilities are measured on an ordinal scale of 0-1, where 1 indicates full health and 0 indicates death. Results: The mean utility scores were 0.854 ± 0.181 and 0.905 ± 0.124 (p > 0.05) and the mean Visual Analogue Scale (VAS) scores were 76.2 ± 12.90 and 77.1 ± 10.26 (p > 0.05) for HD and CAPD patients respectively. There was a significant difference in problems reported between HD (35.1%) and CAPD (15.6%) on usual activities dimension (p = 0.009). The proportion of patients having problems in the pain/discomfort domain in both modalities was high (34.0%). Haemoglobin (< 10 g/dL) (p = 0.003), number of co-morbidities ≥3 (p = 0.004) and wheelchair-bound status (p < 0.001) were significant predictors of poor HRQOL. Conclusions: The present cross-sectional study shows that CAPD patients have a higher utility index score than HD patients but this was not statistically significant. The utilities index score may be used to calculate QALYs.

Original languageEnglish
Article number151
JournalBMC Nephrology
Volume20
Issue number1
DOIs
Publication statusPublished - 30 Apr 2019

Fingerprint

Continuous Ambulatory Peritoneal Dialysis
Malaysia
Renal Dialysis
Dialysis
Quality of Life
Quality-Adjusted Life Years
Cross-Sectional Studies
Morbidity
State Hospitals
Wheelchairs
Health
Visual Analog Scale
Chronic Kidney Failure
Cost-Benefit Analysis
Registries
Hemoglobins
Biomarkers
Demography
Kidney
Pain

Keywords

  • Continuous ambulatory peritoneal dialysis
  • Dialysis
  • EQ-5D
  • Haemodialysis
  • Malaysia
  • Quality adjusted life year
  • Quality of life

ASJC Scopus subject areas

  • Nephrology

Cite this

Health related quality of life of dialysis patients in Malaysia : Haemodialysis versus continuous ambulatory peritoneal dialysis. / Surendra, Naren Kumar; Abdul Manaf, Mohd Rizal; Hooi, Lai Seong; Bavanandan, Sunita; Mohamad Nor, Fariz Safhan; Shah Firdaus Khan, Shahnaz; Ong, Loke Meng; Abdul Gafor, Abdul Halim.

In: BMC Nephrology, Vol. 20, No. 1, 151, 30.04.2019.

Research output: Contribution to journalArticle

Surendra, Naren Kumar ; Abdul Manaf, Mohd Rizal ; Hooi, Lai Seong ; Bavanandan, Sunita ; Mohamad Nor, Fariz Safhan ; Shah Firdaus Khan, Shahnaz ; Ong, Loke Meng ; Abdul Gafor, Abdul Halim. / Health related quality of life of dialysis patients in Malaysia : Haemodialysis versus continuous ambulatory peritoneal dialysis. In: BMC Nephrology. 2019 ; Vol. 20, No. 1.
@article{963e08fe05ef40249676949093da5a1a,
title = "Health related quality of life of dialysis patients in Malaysia: Haemodialysis versus continuous ambulatory peritoneal dialysis",
abstract = "Background: Health related quality of life (HRQOL) is an important predictor of clinical outcomes for End Stage Renal Disease (ESRD) patients and to establish quality adjusted life years (QALYs) for economic evaluation studies. This study aims to measure the health utilities and to identify socio-demographic and clinical factors associated with HRQOL for haemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) in Malaysia. Methods: A total of 141 patients (77 HD and 64 CAPD) from 1 federal and four state hospitals participated in this cross-sectional study. Patients were randomly selected from the National Renal Registry (NRR) using a stratified random sampling. The EQ-5D-3 L questionnaire was used to measure HRQOL. Variables investigated include dialysis modalities, sociodemographic characteristics, co-morbidities and biochemical markers. Utilities are measured on an ordinal scale of 0-1, where 1 indicates full health and 0 indicates death. Results: The mean utility scores were 0.854 ± 0.181 and 0.905 ± 0.124 (p > 0.05) and the mean Visual Analogue Scale (VAS) scores were 76.2 ± 12.90 and 77.1 ± 10.26 (p > 0.05) for HD and CAPD patients respectively. There was a significant difference in problems reported between HD (35.1{\%}) and CAPD (15.6{\%}) on usual activities dimension (p = 0.009). The proportion of patients having problems in the pain/discomfort domain in both modalities was high (34.0{\%}). Haemoglobin (< 10 g/dL) (p = 0.003), number of co-morbidities ≥3 (p = 0.004) and wheelchair-bound status (p < 0.001) were significant predictors of poor HRQOL. Conclusions: The present cross-sectional study shows that CAPD patients have a higher utility index score than HD patients but this was not statistically significant. The utilities index score may be used to calculate QALYs.",
keywords = "Continuous ambulatory peritoneal dialysis, Dialysis, EQ-5D, Haemodialysis, Malaysia, Quality adjusted life year, Quality of life",
author = "Surendra, {Naren Kumar} and {Abdul Manaf}, {Mohd Rizal} and Hooi, {Lai Seong} and Sunita Bavanandan and {Mohamad Nor}, {Fariz Safhan} and {Shah Firdaus Khan}, Shahnaz and Ong, {Loke Meng} and {Abdul Gafor}, {Abdul Halim}",
year = "2019",
month = "4",
day = "30",
doi = "10.1186/s12882-019-1326-x",
language = "English",
volume = "20",
journal = "BMC Nephrology",
issn = "1471-2369",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Health related quality of life of dialysis patients in Malaysia

T2 - Haemodialysis versus continuous ambulatory peritoneal dialysis

AU - Surendra, Naren Kumar

AU - Abdul Manaf, Mohd Rizal

AU - Hooi, Lai Seong

AU - Bavanandan, Sunita

AU - Mohamad Nor, Fariz Safhan

AU - Shah Firdaus Khan, Shahnaz

AU - Ong, Loke Meng

AU - Abdul Gafor, Abdul Halim

PY - 2019/4/30

Y1 - 2019/4/30

N2 - Background: Health related quality of life (HRQOL) is an important predictor of clinical outcomes for End Stage Renal Disease (ESRD) patients and to establish quality adjusted life years (QALYs) for economic evaluation studies. This study aims to measure the health utilities and to identify socio-demographic and clinical factors associated with HRQOL for haemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) in Malaysia. Methods: A total of 141 patients (77 HD and 64 CAPD) from 1 federal and four state hospitals participated in this cross-sectional study. Patients were randomly selected from the National Renal Registry (NRR) using a stratified random sampling. The EQ-5D-3 L questionnaire was used to measure HRQOL. Variables investigated include dialysis modalities, sociodemographic characteristics, co-morbidities and biochemical markers. Utilities are measured on an ordinal scale of 0-1, where 1 indicates full health and 0 indicates death. Results: The mean utility scores were 0.854 ± 0.181 and 0.905 ± 0.124 (p > 0.05) and the mean Visual Analogue Scale (VAS) scores were 76.2 ± 12.90 and 77.1 ± 10.26 (p > 0.05) for HD and CAPD patients respectively. There was a significant difference in problems reported between HD (35.1%) and CAPD (15.6%) on usual activities dimension (p = 0.009). The proportion of patients having problems in the pain/discomfort domain in both modalities was high (34.0%). Haemoglobin (< 10 g/dL) (p = 0.003), number of co-morbidities ≥3 (p = 0.004) and wheelchair-bound status (p < 0.001) were significant predictors of poor HRQOL. Conclusions: The present cross-sectional study shows that CAPD patients have a higher utility index score than HD patients but this was not statistically significant. The utilities index score may be used to calculate QALYs.

AB - Background: Health related quality of life (HRQOL) is an important predictor of clinical outcomes for End Stage Renal Disease (ESRD) patients and to establish quality adjusted life years (QALYs) for economic evaluation studies. This study aims to measure the health utilities and to identify socio-demographic and clinical factors associated with HRQOL for haemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) in Malaysia. Methods: A total of 141 patients (77 HD and 64 CAPD) from 1 federal and four state hospitals participated in this cross-sectional study. Patients were randomly selected from the National Renal Registry (NRR) using a stratified random sampling. The EQ-5D-3 L questionnaire was used to measure HRQOL. Variables investigated include dialysis modalities, sociodemographic characteristics, co-morbidities and biochemical markers. Utilities are measured on an ordinal scale of 0-1, where 1 indicates full health and 0 indicates death. Results: The mean utility scores were 0.854 ± 0.181 and 0.905 ± 0.124 (p > 0.05) and the mean Visual Analogue Scale (VAS) scores were 76.2 ± 12.90 and 77.1 ± 10.26 (p > 0.05) for HD and CAPD patients respectively. There was a significant difference in problems reported between HD (35.1%) and CAPD (15.6%) on usual activities dimension (p = 0.009). The proportion of patients having problems in the pain/discomfort domain in both modalities was high (34.0%). Haemoglobin (< 10 g/dL) (p = 0.003), number of co-morbidities ≥3 (p = 0.004) and wheelchair-bound status (p < 0.001) were significant predictors of poor HRQOL. Conclusions: The present cross-sectional study shows that CAPD patients have a higher utility index score than HD patients but this was not statistically significant. The utilities index score may be used to calculate QALYs.

KW - Continuous ambulatory peritoneal dialysis

KW - Dialysis

KW - EQ-5D

KW - Haemodialysis

KW - Malaysia

KW - Quality adjusted life year

KW - Quality of life

UR - http://www.scopus.com/inward/record.url?scp=85065132614&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065132614&partnerID=8YFLogxK

U2 - 10.1186/s12882-019-1326-x

DO - 10.1186/s12882-019-1326-x

M3 - Article

C2 - 31039745

AN - SCOPUS:85065132614

VL - 20

JO - BMC Nephrology

JF - BMC Nephrology

SN - 1471-2369

IS - 1

M1 - 151

ER -