Health-related quality of life (HRQOL) among pediatric leukemia patients in Malaysia

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12 Citations (Scopus)

Abstract

Background: Health-Related Quality of Life (HRQOL) in pediatric leukemia patients in Malaysia has not been studied before. This was mainly due to a lack of databases on patients in the past. Many patients abandoned treatment or were lost to follow up. With more children now fully compliant and completing treatment nowadays, with higher cure rate, HRQOL has become important for our patients. The purpose of the current study was to determine the HRQOL scores in children with acute leukemia and to compare the scores for those on maintenance chemotherapy with those off-treatment as well as to determine factors which might affect HRQOL. Methods: Seventy-seven children in a pediatric oncology center in Kuala Lumpur, Malaysia diagnosed with acute leukemia were consecutively enrolled, of whom 22 were on maintenance chemotherapy and 55 off-treatment. The Pediatric Quality of Life Inventory (PedsQL™) Scales were used to assess HRQOL. Results: Children on maintenance chemotherapy had significantly lower child self-report HRQOL scores across all domains (P<0.001) especially psychosocial health compared with those who were off-treatment. Also, parents with children on maintenance chemotherapy reported significantly lower HRQOL scores across all domains (P<0.05) except social functioning compared with parents with children off-treatment. Younger child age was associated with lower parent proxy-report total score (P=0.007) Conclusions: Pediatric acute leukemia patients on maintenance chemotherapy experienced significantly poorer HRQOL compared to those off-treatment.

Original languageEnglish
Pages (from-to)105-109
Number of pages5
JournalPediatric Blood and Cancer
Volume57
Issue number1
DOIs
Publication statusPublished - 15 Jul 2011

Fingerprint

Malaysia
Leukemia
Maintenance Chemotherapy
Quality of Life
Pediatrics
Therapeutics
Parents
Lost to Follow-Up
Proxy
Self Report
Databases
Equipment and Supplies
Health

Keywords

  • Acute leukemia
  • Health-related
  • Malaysia
  • Quality of life

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

@article{2a86b3aa107f426989397b977238887d,
title = "Health-related quality of life (HRQOL) among pediatric leukemia patients in Malaysia",
abstract = "Background: Health-Related Quality of Life (HRQOL) in pediatric leukemia patients in Malaysia has not been studied before. This was mainly due to a lack of databases on patients in the past. Many patients abandoned treatment or were lost to follow up. With more children now fully compliant and completing treatment nowadays, with higher cure rate, HRQOL has become important for our patients. The purpose of the current study was to determine the HRQOL scores in children with acute leukemia and to compare the scores for those on maintenance chemotherapy with those off-treatment as well as to determine factors which might affect HRQOL. Methods: Seventy-seven children in a pediatric oncology center in Kuala Lumpur, Malaysia diagnosed with acute leukemia were consecutively enrolled, of whom 22 were on maintenance chemotherapy and 55 off-treatment. The Pediatric Quality of Life Inventory (PedsQL™) Scales were used to assess HRQOL. Results: Children on maintenance chemotherapy had significantly lower child self-report HRQOL scores across all domains (P<0.001) especially psychosocial health compared with those who were off-treatment. Also, parents with children on maintenance chemotherapy reported significantly lower HRQOL scores across all domains (P<0.05) except social functioning compared with parents with children off-treatment. Younger child age was associated with lower parent proxy-report total score (P=0.007) Conclusions: Pediatric acute leukemia patients on maintenance chemotherapy experienced significantly poorer HRQOL compared to those off-treatment.",
keywords = "Acute leukemia, Health-related, Malaysia, Quality of life",
author = "Hamidah Alias and Wong, {Chee Yeng} and {Mohd. Tamil}, Azmi and {Abdul Latiff}, Zarina and {Syed Zakaria}, {Syed Zulkifli} and {A. Jamal}, {A. Rahman}",
year = "2011",
month = "7",
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doi = "10.1002/pbc.23125",
language = "English",
volume = "57",
pages = "105--109",
journal = "Pediatric Blood and Cancer",
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TY - JOUR

T1 - Health-related quality of life (HRQOL) among pediatric leukemia patients in Malaysia

AU - Alias, Hamidah

AU - Wong, Chee Yeng

AU - Mohd. Tamil, Azmi

AU - Abdul Latiff, Zarina

AU - Syed Zakaria, Syed Zulkifli

AU - A. Jamal, A. Rahman

PY - 2011/7/15

Y1 - 2011/7/15

N2 - Background: Health-Related Quality of Life (HRQOL) in pediatric leukemia patients in Malaysia has not been studied before. This was mainly due to a lack of databases on patients in the past. Many patients abandoned treatment or were lost to follow up. With more children now fully compliant and completing treatment nowadays, with higher cure rate, HRQOL has become important for our patients. The purpose of the current study was to determine the HRQOL scores in children with acute leukemia and to compare the scores for those on maintenance chemotherapy with those off-treatment as well as to determine factors which might affect HRQOL. Methods: Seventy-seven children in a pediatric oncology center in Kuala Lumpur, Malaysia diagnosed with acute leukemia were consecutively enrolled, of whom 22 were on maintenance chemotherapy and 55 off-treatment. The Pediatric Quality of Life Inventory (PedsQL™) Scales were used to assess HRQOL. Results: Children on maintenance chemotherapy had significantly lower child self-report HRQOL scores across all domains (P<0.001) especially psychosocial health compared with those who were off-treatment. Also, parents with children on maintenance chemotherapy reported significantly lower HRQOL scores across all domains (P<0.05) except social functioning compared with parents with children off-treatment. Younger child age was associated with lower parent proxy-report total score (P=0.007) Conclusions: Pediatric acute leukemia patients on maintenance chemotherapy experienced significantly poorer HRQOL compared to those off-treatment.

AB - Background: Health-Related Quality of Life (HRQOL) in pediatric leukemia patients in Malaysia has not been studied before. This was mainly due to a lack of databases on patients in the past. Many patients abandoned treatment or were lost to follow up. With more children now fully compliant and completing treatment nowadays, with higher cure rate, HRQOL has become important for our patients. The purpose of the current study was to determine the HRQOL scores in children with acute leukemia and to compare the scores for those on maintenance chemotherapy with those off-treatment as well as to determine factors which might affect HRQOL. Methods: Seventy-seven children in a pediatric oncology center in Kuala Lumpur, Malaysia diagnosed with acute leukemia were consecutively enrolled, of whom 22 were on maintenance chemotherapy and 55 off-treatment. The Pediatric Quality of Life Inventory (PedsQL™) Scales were used to assess HRQOL. Results: Children on maintenance chemotherapy had significantly lower child self-report HRQOL scores across all domains (P<0.001) especially psychosocial health compared with those who were off-treatment. Also, parents with children on maintenance chemotherapy reported significantly lower HRQOL scores across all domains (P<0.05) except social functioning compared with parents with children off-treatment. Younger child age was associated with lower parent proxy-report total score (P=0.007) Conclusions: Pediatric acute leukemia patients on maintenance chemotherapy experienced significantly poorer HRQOL compared to those off-treatment.

KW - Acute leukemia

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KW - Quality of life

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