Has the median nerve involvement in rheumatoid arthritis been overemphasized?

Research output: Contribution to journalArticle

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Abstract

Rheumatoid arthritis (RA) is a well and widely recognized cause of carpal tunnel syndrome(CTS). In the rheumatoid wrist, synovial expansion, joint erosions and ligamentous laxityresult in compression of the median nerve due to increased intracarpal pressure. We evalu-ated the published studies to determine the prevalence of CTS and the characteristics of themedian nerve in RA and its association with clinical parameters such as disease activity, dis-ease duration and seropositivity. A total of 13 studies met the eligibility criteria. Pooled datafrom 8 studies with random selection of RA patients revealed that 86 out of 1561 (5.5%) sub-jects had CTS. Subclinical CTS, on the other hand, had a pooled prevalence of 14.0% (30/215).The cross sectional area of the median nerve of the RA patients without CTS were similar tothe healthy controls. The vast majority of the studies (8/13) disclosed no significant relation-ship between the median nerve findings and the clinical or laboratory parameters in RA. Thelink between RA and the median nerve abnormalities has been overemphasized throughoutthe literature. The prevalence of CTS in RA is similar to the general population without anycorrelation between the median nerve characteristics and the clinical parameters of RA.

Original languageEnglish
Pages (from-to)122-128
Number of pages7
JournalRevista Brasileira de Reumatologia
Volume57
Issue number2
DOIs
Publication statusPublished - 2017

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Median Nerve
Carpal Tunnel Syndrome
Rheumatoid Arthritis
Ships
Wrist
Joints
Pressure
Population

Keywords

  • Carpal tunnel syndrome
  • Median nerve
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Has the median nerve involvement in rheumatoid arthritis been overemphasized? / Rajalingham, Sakthiswary; Singh, Rajesh.

In: Revista Brasileira de Reumatologia, Vol. 57, No. 2, 2017, p. 122-128.

Research output: Contribution to journalArticle

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