Haemophilus influenzae meningitis in Malaysia

I. H M Ismail Hussain, Ali Sofiah, L. C. Ong, K. E. Choo, M. N. Musa, K. H. Teh, H. P. Ng

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective. To determine the pattern of postneonatal childhood meningitis in Malaysia. Methods. Retrospective cross-sectional study involving five pediatric departments in Malaysia. Results. There were 435 cases of clinical meningitis admitted to the five centers. More than 90% of the patients were <5 years old, and one-half were <6 months of age. The estimated overall incidence of childhood meningitis in the first 5 years of life was 76.7 per 100 000 per year. However, of the 435 cases only 71 (16.3%) fulfilled laboratory diagnostic criteria and in only 58 of these was an organism isolated. Nearly one-half (48%) of all bacteriologically proved cases were caused by Haemophilus influenzae type b (Hib). The mortality rate was 12.5% and 21 patients (30%) suffered neurologic sequelae. Conclusions. More than one-half of all cases of culture-positive childhood bacterial meningitis were caused by Hib, although successful isolation of a pathogen occurred in only a small proportion of cases. For this reason the true incidence of Hib meningitis in Malaysia remains unknown. These findings are consistent with previous studies in Malaysia.

Original languageEnglish
JournalPediatric Infectious Disease Journal
Volume17
Issue number9 SUPPL.
DOIs
Publication statusPublished - Sep 1998
Externally publishedYes

Fingerprint

Haemophilus Meningitis
Malaysia
Haemophilus influenzae
Meningitis
Haemophilus influenzae type b
Bacterial Meningitides
Incidence
Nervous System
Cross-Sectional Studies
Pediatrics
Mortality

Keywords

  • Haemophilus influenzae
  • Haemophilus influenzae type b
  • Malaysia
  • Meningitis
  • Vaccine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)

Cite this

Hussain, I. H. M. I., Sofiah, A., Ong, L. C., Choo, K. E., Musa, M. N., Teh, K. H., & Ng, H. P. (1998). Haemophilus influenzae meningitis in Malaysia. Pediatric Infectious Disease Journal, 17(9 SUPPL.). https://doi.org/10.1097/00006454-199809001-00021

Haemophilus influenzae meningitis in Malaysia. / Hussain, I. H M Ismail; Sofiah, Ali; Ong, L. C.; Choo, K. E.; Musa, M. N.; Teh, K. H.; Ng, H. P.

In: Pediatric Infectious Disease Journal, Vol. 17, No. 9 SUPPL., 09.1998.

Research output: Contribution to journalArticle

Hussain, IHMI, Sofiah, A, Ong, LC, Choo, KE, Musa, MN, Teh, KH & Ng, HP 1998, 'Haemophilus influenzae meningitis in Malaysia', Pediatric Infectious Disease Journal, vol. 17, no. 9 SUPPL.. https://doi.org/10.1097/00006454-199809001-00021
Hussain IHMI, Sofiah A, Ong LC, Choo KE, Musa MN, Teh KH et al. Haemophilus influenzae meningitis in Malaysia. Pediatric Infectious Disease Journal. 1998 Sep;17(9 SUPPL.). https://doi.org/10.1097/00006454-199809001-00021
Hussain, I. H M Ismail ; Sofiah, Ali ; Ong, L. C. ; Choo, K. E. ; Musa, M. N. ; Teh, K. H. ; Ng, H. P. / Haemophilus influenzae meningitis in Malaysia. In: Pediatric Infectious Disease Journal. 1998 ; Vol. 17, No. 9 SUPPL.
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