Ekstrak akues Gynura procumbens menurunkan aras glukosa darah dan meningkatkan kualiti sperma tikus teraruh diabetis

Translated title of the contribution: Gynura procumbens leaves aquaeous extract decreased blood glucose level and increased sperm quality in diabetic-induced rats

Halimah Abdullah Sani, Nur Azanim Darus, Mahanem Mat Noor, Isma Illyani Ismail

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Diabetes mellitus has been reported to cause various health complications and increased glucose blood level. The increasing level of glucose in blood was caused by the failure to produce insulin which control blood glucose level. More than 90% of male diabetic patients have problem in sexual abilities such as experiencing low libido, impotence and infertility. Infertility could be due to lost of testicular function to produce normal and healthy sperm in an adequate quantity. This study was carried out to investigate the effects of Gynura procumbens (GP) aqueous extracts on glucose blood level and sperm quality in male diabetic-induced Sprague dawley rats. Diabetic was induced by intravenous injection of streptozotocin (65mg/kg). The sperm quality was determined by evaluating the sperm count, motility and percentage of mortality. Rats were divided into two groups, which were normal and diabetic-induced rats. Each group was then divided into two subgroups; non-treated group (n=5), which served as controls and the treated group (n=5) which were treated with 50 mg/kg GP aqueous leaves extract. Both normal and diabetic rats were forced-fed with the GP extract daily for ten days. The results show that treatment of GP extract decreased the blood glucose level from 15.08 ± 1.878 mmol /L to 10.42 ± 2.71 mmol/L significantly (p<0.05) in diabetic rats. Treatment of GP extract increased the normal sperm count of the diabetic group significantly (p<0.05). The normal sperm count in diabetic rats treated with GP was (50.23 ± 3.12) x 107 compared to untreated-diabetic group (39.93 ± 8.06) x 107. Most of the sperm motility in the untreated diabetic rats were in grade d (immotile) with 38.5%. However, diabetic rats treated with GP had a decrease of grade d sperm to 30.48% and an increase of grade a (progressive motility) spermfrom 31.25% to 34.86%. The diabetic rats treated with GP also had a significant reduction (p<0.05) in percentage of sperm mortality, from 50.09 ± 14.34% to 30.57 ± 4.61 %. These results show that the administration of Gynura procumbens aqueous extract had the ability to decrease blood glucose level, restore the fertility and increase spermatogenesis in male diabetic rats.

Original languageUndefined/Unknown
Pages (from-to)435-441
Number of pages7
JournalSains Malaysiana
Volume37
Issue number4
Publication statusPublished - Dec 2008

Fingerprint

Blood Glucose
Spermatozoa
Sperm Count
Sperm Motility
Infertility
Libido
Aptitude
Mortality
Erectile Dysfunction
Spermatogenesis
Streptozocin
Intravenous Injections
Fertility
Sprague Dawley Rats
Diabetes Mellitus
Insulin
Control Groups
Health
Therapeutics

Keywords

  • Diabetes
  • Gynura procumbens
  • Sperm quality

ASJC Scopus subject areas

  • General

Cite this

Ekstrak akues Gynura procumbens menurunkan aras glukosa darah dan meningkatkan kualiti sperma tikus teraruh diabetis. / Sani, Halimah Abdullah; Darus, Nur Azanim; Mat Noor, Mahanem; Ismail, Isma Illyani.

In: Sains Malaysiana, Vol. 37, No. 4, 12.2008, p. 435-441.

Research output: Contribution to journalArticle

Sani, Halimah Abdullah ; Darus, Nur Azanim ; Mat Noor, Mahanem ; Ismail, Isma Illyani. / Ekstrak akues Gynura procumbens menurunkan aras glukosa darah dan meningkatkan kualiti sperma tikus teraruh diabetis. In: Sains Malaysiana. 2008 ; Vol. 37, No. 4. pp. 435-441.
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abstract = "Diabetes mellitus has been reported to cause various health complications and increased glucose blood level. The increasing level of glucose in blood was caused by the failure to produce insulin which control blood glucose level. More than 90{\%} of male diabetic patients have problem in sexual abilities such as experiencing low libido, impotence and infertility. Infertility could be due to lost of testicular function to produce normal and healthy sperm in an adequate quantity. This study was carried out to investigate the effects of Gynura procumbens (GP) aqueous extracts on glucose blood level and sperm quality in male diabetic-induced Sprague dawley rats. Diabetic was induced by intravenous injection of streptozotocin (65mg/kg). The sperm quality was determined by evaluating the sperm count, motility and percentage of mortality. Rats were divided into two groups, which were normal and diabetic-induced rats. Each group was then divided into two subgroups; non-treated group (n=5), which served as controls and the treated group (n=5) which were treated with 50 mg/kg GP aqueous leaves extract. Both normal and diabetic rats were forced-fed with the GP extract daily for ten days. The results show that treatment of GP extract decreased the blood glucose level from 15.08 ± 1.878 mmol /L to 10.42 ± 2.71 mmol/L significantly (p<0.05) in diabetic rats. Treatment of GP extract increased the normal sperm count of the diabetic group significantly (p<0.05). The normal sperm count in diabetic rats treated with GP was (50.23 ± 3.12) x 107 compared to untreated-diabetic group (39.93 ± 8.06) x 107. Most of the sperm motility in the untreated diabetic rats were in grade d (immotile) with 38.5{\%}. However, diabetic rats treated with GP had a decrease of grade d sperm to 30.48{\%} and an increase of grade a (progressive motility) spermfrom 31.25{\%} to 34.86{\%}. The diabetic rats treated with GP also had a significant reduction (p<0.05) in percentage of sperm mortality, from 50.09 ± 14.34{\%} to 30.57 ± 4.61 {\%}. These results show that the administration of Gynura procumbens aqueous extract had the ability to decrease blood glucose level, restore the fertility and increase spermatogenesis in male diabetic rats.",
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