GnRH agonist and GnRH antagonist in intracytoplasmic injection cycles

Zainul Rashid Mohd. Razi, Fee Bee Ong, Mohd Hashim Omar, S. P. Ng, A. Nurshaireen, N. S M N Sharifah-Teh, A. H. Fazilah, M. A. Zamzarina

Research output: Contribution to journalArticle

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Abstract

The long agonistic protocol for controlled ovarian hyperstimulation (COH) is effective and used most often, thus is considered the gold standard. Therefore any new regimen has to be compared in its results with those obtained with the long protocol. This report compares the efficacy of GnRH agonist and antagonist in a retrospective study of IVF/ ICSI carried out in a tertiary teaching hospital from 2003 to 2006. Only the first COH cycle followed by IVF-ICSI from 200 couples (agonist=120 and antagonist=80) were analysed. The end points studied included the number of oocytes recovered, number of mature (MII) oocytes, fertilization, cleavage, morphology based embryo quality, pregnancy rate, quantity and cost of gonadotrophin. The average age of female subjects was 35.1±4.7 years with 50% being 35 years and above. Major infertility factors were tubal blockage, male factor and endometriosis altogether comprising 68%. GnRH agonist and antagonist cycle parameters were comparable except lesser amount of gonadotrophin was used with lower resultant costs (both p<0.0005) in antagonistic regime. Antagonist regime produce somewhat more good quality embryos (p=0.065), an insignificant difference. A clinical pregnancy rate per embryo transfer of 16.3% in agonist and 20.6% in antagonist regime was achieved respectively. In conclusion, GnRH antagonist protocol produced a COH response, embryonic development and pregnancy rates on par to GnRH agonist regime. Moreover GnRH antagonist protocol required a shorter stimulation period plus fewer complications. Hence GnRH antagonist regime provided means for a friendlier, convenient and cost effective protocol for patients.

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalMedical Journal of Malaysia
Volume63
Issue number2
Publication statusPublished - Jun 2008

Fingerprint

Gonadotropin-Releasing Hormone
Injections
Pregnancy Rate
Intracytoplasmic Sperm Injections
Gonadotropins
Costs and Cost Analysis
Oocytes
Embryonic Structures
Embryo Transfer
Endometriosis
Menstrual Cycle
Fertilization
Tertiary Care Centers
Teaching Hospitals
Infertility
Embryonic Development
Retrospective Studies

Keywords

  • Assisted reproduction
  • GnRH agonist
  • GnRH antagonist
  • Intracytoplasmic sperm injection
  • Ovarian stimulation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mohd. Razi, Z. R., Ong, F. B., Omar, M. H., Ng, S. P., Nurshaireen, A., Sharifah-Teh, N. S. M. N., ... Zamzarina, M. A. (2008). GnRH agonist and GnRH antagonist in intracytoplasmic injection cycles. Medical Journal of Malaysia, 63(2), 113-117.

GnRH agonist and GnRH antagonist in intracytoplasmic injection cycles. / Mohd. Razi, Zainul Rashid; Ong, Fee Bee; Omar, Mohd Hashim; Ng, S. P.; Nurshaireen, A.; Sharifah-Teh, N. S M N; Fazilah, A. H.; Zamzarina, M. A.

In: Medical Journal of Malaysia, Vol. 63, No. 2, 06.2008, p. 113-117.

Research output: Contribution to journalArticle

Mohd. Razi, ZR, Ong, FB, Omar, MH, Ng, SP, Nurshaireen, A, Sharifah-Teh, NSMN, Fazilah, AH & Zamzarina, MA 2008, 'GnRH agonist and GnRH antagonist in intracytoplasmic injection cycles', Medical Journal of Malaysia, vol. 63, no. 2, pp. 113-117.
Mohd. Razi ZR, Ong FB, Omar MH, Ng SP, Nurshaireen A, Sharifah-Teh NSMN et al. GnRH agonist and GnRH antagonist in intracytoplasmic injection cycles. Medical Journal of Malaysia. 2008 Jun;63(2):113-117.
Mohd. Razi, Zainul Rashid ; Ong, Fee Bee ; Omar, Mohd Hashim ; Ng, S. P. ; Nurshaireen, A. ; Sharifah-Teh, N. S M N ; Fazilah, A. H. ; Zamzarina, M. A. / GnRH agonist and GnRH antagonist in intracytoplasmic injection cycles. In: Medical Journal of Malaysia. 2008 ; Vol. 63, No. 2. pp. 113-117.
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