Glutathione S-transferase and gamma-glutamyl transpeptidase activities in cultured rat hepatocytes treated with tocotrienol and tocopherol

F. B. Ong, W. Z Wan Ngah, N. A. Shamaan, A. G Md Top, A. Marzuki, A. K. Khalid

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    1. The effect of tocotrienol and tocopherol on glutathione S-transferase (GST) and gammaglutamyl transpeptidase (GGT) activities in cultured rat hepatocytes were investigated. 2. Tocotrienol and tocopherol significantly decreased GGT activities at 5 days in culture but tocotrienol also significantly decreased GGT activities at 1-2 days. 3. Tocotrienol and tocopherol treatment significantly decreased GST activities at 3 days compared to the control but tocotrienol also decreased GST activities at 1-3 days. 4. Tocotrienol showed a more pronounced effect at a dosage of greater than 50 μM tocotrienol at 1-3 days in culture compared to the control.

    Original languageEnglish
    Pages (from-to)237-240
    Number of pages4
    JournalComparative Biochemistry and Physiology. Part C: Comparative
    Volume106
    Issue number1
    DOIs
    Publication statusPublished - 1993

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    Tocotrienols
    Tocopherols
    gamma-Glutamyltransferase
    Glutathione Transferase
    Hepatocytes
    Peptidyl Transferases

    ASJC Scopus subject areas

    • Immunology
    • Pharmacology

    Cite this

    Glutathione S-transferase and gamma-glutamyl transpeptidase activities in cultured rat hepatocytes treated with tocotrienol and tocopherol. / Ong, F. B.; Ngah, W. Z Wan; Shamaan, N. A.; Top, A. G Md; Marzuki, A.; Khalid, A. K.

    In: Comparative Biochemistry and Physiology. Part C: Comparative, Vol. 106, No. 1, 1993, p. 237-240.

    Research output: Contribution to journalArticle

    Ong, F. B. ; Ngah, W. Z Wan ; Shamaan, N. A. ; Top, A. G Md ; Marzuki, A. ; Khalid, A. K. / Glutathione S-transferase and gamma-glutamyl transpeptidase activities in cultured rat hepatocytes treated with tocotrienol and tocopherol. In: Comparative Biochemistry and Physiology. Part C: Comparative. 1993 ; Vol. 106, No. 1. pp. 237-240.
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    abstract = "1. The effect of tocotrienol and tocopherol on glutathione S-transferase (GST) and gammaglutamyl transpeptidase (GGT) activities in cultured rat hepatocytes were investigated. 2. Tocotrienol and tocopherol significantly decreased GGT activities at 5 days in culture but tocotrienol also significantly decreased GGT activities at 1-2 days. 3. Tocotrienol and tocopherol treatment significantly decreased GST activities at 3 days compared to the control but tocotrienol also decreased GST activities at 1-3 days. 4. Tocotrienol showed a more pronounced effect at a dosage of greater than 50 μM tocotrienol at 1-3 days in culture compared to the control.",
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    AU - Ong, F. B.

    AU - Ngah, W. Z Wan

    AU - Shamaan, N. A.

    AU - Top, A. G Md

    AU - Marzuki, A.

    AU - Khalid, A. K.

    PY - 1993

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    N2 - 1. The effect of tocotrienol and tocopherol on glutathione S-transferase (GST) and gammaglutamyl transpeptidase (GGT) activities in cultured rat hepatocytes were investigated. 2. Tocotrienol and tocopherol significantly decreased GGT activities at 5 days in culture but tocotrienol also significantly decreased GGT activities at 1-2 days. 3. Tocotrienol and tocopherol treatment significantly decreased GST activities at 3 days compared to the control but tocotrienol also decreased GST activities at 1-3 days. 4. Tocotrienol showed a more pronounced effect at a dosage of greater than 50 μM tocotrienol at 1-3 days in culture compared to the control.

    AB - 1. The effect of tocotrienol and tocopherol on glutathione S-transferase (GST) and gammaglutamyl transpeptidase (GGT) activities in cultured rat hepatocytes were investigated. 2. Tocotrienol and tocopherol significantly decreased GGT activities at 5 days in culture but tocotrienol also significantly decreased GGT activities at 1-2 days. 3. Tocotrienol and tocopherol treatment significantly decreased GST activities at 3 days compared to the control but tocotrienol also decreased GST activities at 1-3 days. 4. Tocotrienol showed a more pronounced effect at a dosage of greater than 50 μM tocotrienol at 1-3 days in culture compared to the control.

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