Abstract
Background: Neurological disorders are now the leading source of disability globally, and ageing is increasing the burden of neurodegenerative disorders, including Parkinson's disease. We aimed to determine the global burden of Parkinson's disease between 1990 and 2016 to identify trends and to enable appropriate public health, medical, and scientific responses. Methods: Through a systematic analysis of epidemiological studies, we estimated global, regional, and country-specific prevalence and years of life lived with disability for Parkinson's disease from 1990 to 2016. We estimated the proportion of mild, moderate, and severe Parkinson's disease on the basis of studies that used the Hoehn and Yahr scale and assigned disability weights to each level. We jointly modelled prevalence and excess mortality risk in a natural history model to derive estimates of deaths due to Parkinson's disease. Death counts were multiplied by values from the Global Burden of Disease study's standard life expectancy to compute years of life lost. Disability-adjusted life-years (DALYs) were computed as the sum of years lived with disability and years of life lost. We also analysed results based on the Socio-demographic Index, a compound measure of income per capita, education, and fertility. Findings: In 2016, 6·1 million (95% uncertainty interval [UI] 5·0–7·3) individuals had Parkinson's disease globally, compared with 2·5 million (2·0–3·0) in 1990. This increase was not solely due to increasing numbers of older people, because age-standardised prevalence rates increased by 21·7% (95% UI 18·1–25·3) over the same period (compared with an increase of 74·3%, 95% UI 69·2–79·6, for crude prevalence rates). Parkinson's disease caused 3·2 million (95% UI 2·6–4·0) DALYs and 211 296 deaths (95% UI 167 771–265 160) in 2016. The male-to-female ratios of age-standardised prevalence rates were similar in 2016 (1·40, 95% UI 1·36–1·43) and 1990 (1·37, 1·34–1·40). From 1990 to 2016, age-standardised prevalence, DALY rates, and death rates increased for all global burden of disease regions except for southern Latin America, eastern Europe, and Oceania. In addition, age-standardised DALY rates generally increased across the Socio-demographic Index. Interpretation: Over the past generation, the global burden of Parkinson's disease has more than doubled as a result of increasing numbers of older people, with potential contributions from longer disease duration and environmental factors. Demographic and potentially other factors are poised to increase the future burden of Parkinson's disease substantially. Funding: Bill & Melinda Gates Foundation.
| Original language | English |
|---|---|
| Pages (from-to) | 939-953 |
| Number of pages | 15 |
| Journal | The Lancet Neurology |
| Volume | 17 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 1 Nov 2018 |
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ASJC Scopus subject areas
- Clinical Neurology
Cite this
Global, regional, and national burden of Parkinson's disease, 1990–2016 : a systematic analysis for the Global Burden of Disease Study 2016. / GBD 2016 Parkinson’s Disease Collaborators.
In: The Lancet Neurology, Vol. 17, No. 11, 01.11.2018, p. 939-953.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Global, regional, and national burden of Parkinson's disease, 1990–2016
T2 - a systematic analysis for the Global Burden of Disease Study 2016
AU - GBD 2016 Parkinson’s Disease Collaborators
AU - Ray Dorsey, E.
AU - Elbaz, Alexis
AU - Nichols, Emma
AU - Abd-Allah, Foad
AU - Abdelalim, Ahmed
AU - Adsuar, Jose C.
AU - Ansha, Mustafa Geleto
AU - Brayne, Carol
AU - Choi, Jee Young J.
AU - Collado-Mateo, Daniel
AU - Dahodwala, Nabila
AU - Do, Huyen Phuc
AU - Edessa, Dumessa
AU - Endres, Matthias
AU - Fereshtehnejad, Seyed Mohammad
AU - Foreman, Kyle J.
AU - Gankpe, Fortune Gbetoho
AU - Gupta, Rahul
AU - Hankey, Graeme J.
AU - Hay, Simon I.
AU - Hegazy, Mohamed I.
AU - Hibstu, Desalegn T.
AU - Kasaeian, Amir
AU - Khader, Yousef
AU - Khalil, Ibrahim
AU - Khang, Young Ho
AU - Kim, Yun Jin
AU - Kokubo, Yoshihiro
AU - Logroscino, Giancarlo
AU - Massano, João
AU - Mohamed Ibrahim, Norlinah
AU - Mohammed, Mohammed A.
AU - Mohammadi, Alireza
AU - Moradi-Lakeh, Maziar
AU - Naghavi, Mohsen
AU - Nguyen, Binh Thanh
AU - Nirayo, Yirga Legesse
AU - Ogbo, Felix Akpojene
AU - Owolabi, Mayowa Ojo
AU - Pereira, David M.
AU - Postma, Maarten J.
AU - Qorbani, Mostafa
AU - Rahman, Muhammad Aziz
AU - Roba, Kedir T.
AU - Safari, Hosein
AU - Safiri, Saeid
AU - Satpathy, Maheswar
AU - Sawhney, Monika
AU - Shafieesabet, Azadeh
AU - Shiferaw, Mekonnen Sisay
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Background: Neurological disorders are now the leading source of disability globally, and ageing is increasing the burden of neurodegenerative disorders, including Parkinson's disease. We aimed to determine the global burden of Parkinson's disease between 1990 and 2016 to identify trends and to enable appropriate public health, medical, and scientific responses. Methods: Through a systematic analysis of epidemiological studies, we estimated global, regional, and country-specific prevalence and years of life lived with disability for Parkinson's disease from 1990 to 2016. We estimated the proportion of mild, moderate, and severe Parkinson's disease on the basis of studies that used the Hoehn and Yahr scale and assigned disability weights to each level. We jointly modelled prevalence and excess mortality risk in a natural history model to derive estimates of deaths due to Parkinson's disease. Death counts were multiplied by values from the Global Burden of Disease study's standard life expectancy to compute years of life lost. Disability-adjusted life-years (DALYs) were computed as the sum of years lived with disability and years of life lost. We also analysed results based on the Socio-demographic Index, a compound measure of income per capita, education, and fertility. Findings: In 2016, 6·1 million (95% uncertainty interval [UI] 5·0–7·3) individuals had Parkinson's disease globally, compared with 2·5 million (2·0–3·0) in 1990. This increase was not solely due to increasing numbers of older people, because age-standardised prevalence rates increased by 21·7% (95% UI 18·1–25·3) over the same period (compared with an increase of 74·3%, 95% UI 69·2–79·6, for crude prevalence rates). Parkinson's disease caused 3·2 million (95% UI 2·6–4·0) DALYs and 211 296 deaths (95% UI 167 771–265 160) in 2016. The male-to-female ratios of age-standardised prevalence rates were similar in 2016 (1·40, 95% UI 1·36–1·43) and 1990 (1·37, 1·34–1·40). From 1990 to 2016, age-standardised prevalence, DALY rates, and death rates increased for all global burden of disease regions except for southern Latin America, eastern Europe, and Oceania. In addition, age-standardised DALY rates generally increased across the Socio-demographic Index. Interpretation: Over the past generation, the global burden of Parkinson's disease has more than doubled as a result of increasing numbers of older people, with potential contributions from longer disease duration and environmental factors. Demographic and potentially other factors are poised to increase the future burden of Parkinson's disease substantially. Funding: Bill & Melinda Gates Foundation.
AB - Background: Neurological disorders are now the leading source of disability globally, and ageing is increasing the burden of neurodegenerative disorders, including Parkinson's disease. We aimed to determine the global burden of Parkinson's disease between 1990 and 2016 to identify trends and to enable appropriate public health, medical, and scientific responses. Methods: Through a systematic analysis of epidemiological studies, we estimated global, regional, and country-specific prevalence and years of life lived with disability for Parkinson's disease from 1990 to 2016. We estimated the proportion of mild, moderate, and severe Parkinson's disease on the basis of studies that used the Hoehn and Yahr scale and assigned disability weights to each level. We jointly modelled prevalence and excess mortality risk in a natural history model to derive estimates of deaths due to Parkinson's disease. Death counts were multiplied by values from the Global Burden of Disease study's standard life expectancy to compute years of life lost. Disability-adjusted life-years (DALYs) were computed as the sum of years lived with disability and years of life lost. We also analysed results based on the Socio-demographic Index, a compound measure of income per capita, education, and fertility. Findings: In 2016, 6·1 million (95% uncertainty interval [UI] 5·0–7·3) individuals had Parkinson's disease globally, compared with 2·5 million (2·0–3·0) in 1990. This increase was not solely due to increasing numbers of older people, because age-standardised prevalence rates increased by 21·7% (95% UI 18·1–25·3) over the same period (compared with an increase of 74·3%, 95% UI 69·2–79·6, for crude prevalence rates). Parkinson's disease caused 3·2 million (95% UI 2·6–4·0) DALYs and 211 296 deaths (95% UI 167 771–265 160) in 2016. The male-to-female ratios of age-standardised prevalence rates were similar in 2016 (1·40, 95% UI 1·36–1·43) and 1990 (1·37, 1·34–1·40). From 1990 to 2016, age-standardised prevalence, DALY rates, and death rates increased for all global burden of disease regions except for southern Latin America, eastern Europe, and Oceania. In addition, age-standardised DALY rates generally increased across the Socio-demographic Index. Interpretation: Over the past generation, the global burden of Parkinson's disease has more than doubled as a result of increasing numbers of older people, with potential contributions from longer disease duration and environmental factors. Demographic and potentially other factors are poised to increase the future burden of Parkinson's disease substantially. Funding: Bill & Melinda Gates Foundation.
UR - http://www.scopus.com/inward/record.url?scp=85055021376&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055021376&partnerID=8YFLogxK
U2 - 10.1016/S1474-4422(18)30295-3
DO - 10.1016/S1474-4422(18)30295-3
M3 - Article
C2 - 30287051
AN - SCOPUS:85055021376
VL - 17
SP - 939
EP - 953
JO - The Lancet Neurology
JF - The Lancet Neurology
SN - 1474-4422
IS - 11
ER -