Global, regional, and national burden of neurological disorders during 1990–2015

a systematic analysis for the Global Burden of Disease Study 2015

GBD 2015 Neurological Disorders Collaborator Group

Research output: Contribution to journalArticle

305 Citations (Scopus)

Abstract

Background Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this systematic analysis, we quantified the global disease burden due to neurological disorders in 2015 and its relationship with country development level. Methods We estimated global and country-specific prevalence, mortality, disability-adjusted life-years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) for various neurological disorders that in the GBD classification have been previously spread across multiple disease groupings. The more inclusive grouping of neurological disorders included stroke, meningitis, encephalitis, tetanus, Alzheimer's disease and other dementias, Parkinson's disease, epilepsy, multiple sclerosis, motor neuron disease, migraine, tension-type headache, medication overuse headache, brain and nervous system cancers, and a residual category of other neurological disorders. We also analysed results based on the Socio-demographic Index (SDI), a compound measure of income per capita, education, and fertility, to identify patterns associated with development and how countries fare against expected outcomes relative to their level of development. Findings Neurological disorders ranked as the leading cause group of DALYs in 2015 (250·7 [95% uncertainty interval (UI) 229·1 to 274·7] million, comprising 10·2% of global DALYs) and the second-leading cause group of deaths (9·4 [9·1 to 9·7] million], comprising 16·8% of global deaths). The most prevalent neurological disorders were tension-type headache (1505·9 [UI 1337·3 to 1681·6 million cases]), migraine (958·8 [872·1 to 1055·6] million), medication overuse headache (58·5 [50·8 to 67·4 million]), and Alzheimer's disease and other dementias (46·0 [40·2 to 52·7 million]). Between 1990 and 2015, the number of deaths from neurological disorders increased by 36·7%, and the number of DALYs by 7·4%. These increases occurred despite decreases in age-standardised rates of death and DALYs of 26·1% and 29·7%, respectively; stroke and communicable neurological disorders were responsible for most of these decreases. Communicable neurological disorders were the largest cause of DALYs in countries with low SDI. Stroke rates were highest at middle levels of SDI and lowest at the highest SDI. Most of the changes in DALY rates of neurological disorders with development were driven by changes in YLLs. Interpretation Neurological disorders are an important cause of disability and death worldwide. Globally, the burden of neurological disorders has increased substantially over the past 25 years because of expanding population numbers and ageing, despite substantial decreases in mortality rates from stroke and communicable neurological disorders. The number of patients who will need care by clinicians with expertise in neurological conditions will continue to grow in coming decades. Policy makers and health-care providers should be aware of these trends to provide adequate services. Funding Bill & Melinda Gates Foundation.

Original languageEnglish
Pages (from-to)877-897
Number of pages21
JournalThe Lancet Neurology
Volume16
Issue number11
DOIs
Publication statusPublished - 1 Nov 2017

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Nervous System Diseases
Quality-Adjusted Life Years
Secondary Headache Disorders
Stroke
Demography
Tension-Type Headache
Global Burden of Disease
Migraine Disorders
Uncertainty
Dementia
Mortality
Cause of Death
Alzheimer Disease
Motor Neuron Disease
Health Planning
Resource Allocation
Health Resources
Tetanus
Residual Neoplasm
Encephalitis

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Global, regional, and national burden of neurological disorders during 1990–2015 : a systematic analysis for the Global Burden of Disease Study 2015. / GBD 2015 Neurological Disorders Collaborator Group.

In: The Lancet Neurology, Vol. 16, No. 11, 01.11.2017, p. 877-897.

Research output: Contribution to journalArticle

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title = "Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015",
abstract = "Background Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this systematic analysis, we quantified the global disease burden due to neurological disorders in 2015 and its relationship with country development level. Methods We estimated global and country-specific prevalence, mortality, disability-adjusted life-years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) for various neurological disorders that in the GBD classification have been previously spread across multiple disease groupings. The more inclusive grouping of neurological disorders included stroke, meningitis, encephalitis, tetanus, Alzheimer's disease and other dementias, Parkinson's disease, epilepsy, multiple sclerosis, motor neuron disease, migraine, tension-type headache, medication overuse headache, brain and nervous system cancers, and a residual category of other neurological disorders. We also analysed results based on the Socio-demographic Index (SDI), a compound measure of income per capita, education, and fertility, to identify patterns associated with development and how countries fare against expected outcomes relative to their level of development. Findings Neurological disorders ranked as the leading cause group of DALYs in 2015 (250·7 [95{\%} uncertainty interval (UI) 229·1 to 274·7] million, comprising 10·2{\%} of global DALYs) and the second-leading cause group of deaths (9·4 [9·1 to 9·7] million], comprising 16·8{\%} of global deaths). The most prevalent neurological disorders were tension-type headache (1505·9 [UI 1337·3 to 1681·6 million cases]), migraine (958·8 [872·1 to 1055·6] million), medication overuse headache (58·5 [50·8 to 67·4 million]), and Alzheimer's disease and other dementias (46·0 [40·2 to 52·7 million]). Between 1990 and 2015, the number of deaths from neurological disorders increased by 36·7{\%}, and the number of DALYs by 7·4{\%}. These increases occurred despite decreases in age-standardised rates of death and DALYs of 26·1{\%} and 29·7{\%}, respectively; stroke and communicable neurological disorders were responsible for most of these decreases. Communicable neurological disorders were the largest cause of DALYs in countries with low SDI. Stroke rates were highest at middle levels of SDI and lowest at the highest SDI. Most of the changes in DALY rates of neurological disorders with development were driven by changes in YLLs. Interpretation Neurological disorders are an important cause of disability and death worldwide. Globally, the burden of neurological disorders has increased substantially over the past 25 years because of expanding population numbers and ageing, despite substantial decreases in mortality rates from stroke and communicable neurological disorders. The number of patients who will need care by clinicians with expertise in neurological conditions will continue to grow in coming decades. Policy makers and health-care providers should be aware of these trends to provide adequate services. Funding Bill & Melinda Gates Foundation.",
author = "{GBD 2015 Neurological Disorders Collaborator Group} and Feigin, {Valery L.} and Abajobir, {Amanuel Alemu} and Abate, {Kalkidan Hassen} and Foad Abd-Allah and Abdulle, {Abdishakur M.} and Abera, {Semaw Ferede} and Abyu, {Gebre Yitayih} and Ahmed, {Muktar Beshir} and Aichour, {Amani Nidhal} and Ibtihel Aichour and Aichour, {Miloud Taki Eddine} and Akinyemi, {Rufus Olusola} and Samer Alabed and Rajaa Al-Raddadi and Nelson Alvis-Guzman and Amare, {Azmeraw T.} and Hossein Ansari and Palwasha Anwari and Johan {\"A}rnl{\"o}v and Hamid Asayesh and Asgedom, {Solomon Weldegebreal} and Atey, {Tesfay Mehari} and Leticia Avila-Burgos and Euripide Frinel and Avokpaho, {G. Arthur} and Aleksandra Barac and Miguel Barboza and Barker-Collo, {Suzanne L.} and Till B{\"a}rnighausen and Neeraj Bedi and Ettore Beghi and Bennett, {Derrick A.} and Bensenor, {Isabela M.} and Adugnaw Berhane and Betsu, {Balem Demtsu} and Soumyadeep Bhaumik and Birlik, {Sait Mentes} and Stan Biryukov and Boneya, {Dube Jara} and Bulto, {Lemma Negesa Bulto} and H{\'e}l{\`e}ne Carabin and Daniel Casey and Casta{\~n}eda-Orjuela, {Carlos A.} and Ferr{\'a}n Catal{\'a}-L{\'o}pez and Honglei Chen and Chitheer, {Abdulaal A.} and Rajiv Chowdhury and Hanne Christensen and Lalit Dandona and Ramesh Sahathevan",
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TY - JOUR

T1 - Global, regional, and national burden of neurological disorders during 1990–2015

T2 - a systematic analysis for the Global Burden of Disease Study 2015

AU - GBD 2015 Neurological Disorders Collaborator Group

AU - Feigin, Valery L.

AU - Abajobir, Amanuel Alemu

AU - Abate, Kalkidan Hassen

AU - Abd-Allah, Foad

AU - Abdulle, Abdishakur M.

AU - Abera, Semaw Ferede

AU - Abyu, Gebre Yitayih

AU - Ahmed, Muktar Beshir

AU - Aichour, Amani Nidhal

AU - Aichour, Ibtihel

AU - Aichour, Miloud Taki Eddine

AU - Akinyemi, Rufus Olusola

AU - Alabed, Samer

AU - Al-Raddadi, Rajaa

AU - Alvis-Guzman, Nelson

AU - Amare, Azmeraw T.

AU - Ansari, Hossein

AU - Anwari, Palwasha

AU - Ärnlöv, Johan

AU - Asayesh, Hamid

AU - Asgedom, Solomon Weldegebreal

AU - Atey, Tesfay Mehari

AU - Avila-Burgos, Leticia

AU - Frinel, Euripide

AU - Avokpaho, G. Arthur

AU - Barac, Aleksandra

AU - Barboza, Miguel

AU - Barker-Collo, Suzanne L.

AU - Bärnighausen, Till

AU - Bedi, Neeraj

AU - Beghi, Ettore

AU - Bennett, Derrick A.

AU - Bensenor, Isabela M.

AU - Berhane, Adugnaw

AU - Betsu, Balem Demtsu

AU - Bhaumik, Soumyadeep

AU - Birlik, Sait Mentes

AU - Biryukov, Stan

AU - Boneya, Dube Jara

AU - Bulto, Lemma Negesa Bulto

AU - Carabin, Hélène

AU - Casey, Daniel

AU - Castañeda-Orjuela, Carlos A.

AU - Catalá-López, Ferrán

AU - Chen, Honglei

AU - Chitheer, Abdulaal A.

AU - Chowdhury, Rajiv

AU - Christensen, Hanne

AU - Dandona, Lalit

AU - Sahathevan, Ramesh

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Background Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this systematic analysis, we quantified the global disease burden due to neurological disorders in 2015 and its relationship with country development level. Methods We estimated global and country-specific prevalence, mortality, disability-adjusted life-years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) for various neurological disorders that in the GBD classification have been previously spread across multiple disease groupings. The more inclusive grouping of neurological disorders included stroke, meningitis, encephalitis, tetanus, Alzheimer's disease and other dementias, Parkinson's disease, epilepsy, multiple sclerosis, motor neuron disease, migraine, tension-type headache, medication overuse headache, brain and nervous system cancers, and a residual category of other neurological disorders. We also analysed results based on the Socio-demographic Index (SDI), a compound measure of income per capita, education, and fertility, to identify patterns associated with development and how countries fare against expected outcomes relative to their level of development. Findings Neurological disorders ranked as the leading cause group of DALYs in 2015 (250·7 [95% uncertainty interval (UI) 229·1 to 274·7] million, comprising 10·2% of global DALYs) and the second-leading cause group of deaths (9·4 [9·1 to 9·7] million], comprising 16·8% of global deaths). The most prevalent neurological disorders were tension-type headache (1505·9 [UI 1337·3 to 1681·6 million cases]), migraine (958·8 [872·1 to 1055·6] million), medication overuse headache (58·5 [50·8 to 67·4 million]), and Alzheimer's disease and other dementias (46·0 [40·2 to 52·7 million]). Between 1990 and 2015, the number of deaths from neurological disorders increased by 36·7%, and the number of DALYs by 7·4%. These increases occurred despite decreases in age-standardised rates of death and DALYs of 26·1% and 29·7%, respectively; stroke and communicable neurological disorders were responsible for most of these decreases. Communicable neurological disorders were the largest cause of DALYs in countries with low SDI. Stroke rates were highest at middle levels of SDI and lowest at the highest SDI. Most of the changes in DALY rates of neurological disorders with development were driven by changes in YLLs. Interpretation Neurological disorders are an important cause of disability and death worldwide. Globally, the burden of neurological disorders has increased substantially over the past 25 years because of expanding population numbers and ageing, despite substantial decreases in mortality rates from stroke and communicable neurological disorders. The number of patients who will need care by clinicians with expertise in neurological conditions will continue to grow in coming decades. Policy makers and health-care providers should be aware of these trends to provide adequate services. Funding Bill & Melinda Gates Foundation.

AB - Background Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this systematic analysis, we quantified the global disease burden due to neurological disorders in 2015 and its relationship with country development level. Methods We estimated global and country-specific prevalence, mortality, disability-adjusted life-years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) for various neurological disorders that in the GBD classification have been previously spread across multiple disease groupings. The more inclusive grouping of neurological disorders included stroke, meningitis, encephalitis, tetanus, Alzheimer's disease and other dementias, Parkinson's disease, epilepsy, multiple sclerosis, motor neuron disease, migraine, tension-type headache, medication overuse headache, brain and nervous system cancers, and a residual category of other neurological disorders. We also analysed results based on the Socio-demographic Index (SDI), a compound measure of income per capita, education, and fertility, to identify patterns associated with development and how countries fare against expected outcomes relative to their level of development. Findings Neurological disorders ranked as the leading cause group of DALYs in 2015 (250·7 [95% uncertainty interval (UI) 229·1 to 274·7] million, comprising 10·2% of global DALYs) and the second-leading cause group of deaths (9·4 [9·1 to 9·7] million], comprising 16·8% of global deaths). The most prevalent neurological disorders were tension-type headache (1505·9 [UI 1337·3 to 1681·6 million cases]), migraine (958·8 [872·1 to 1055·6] million), medication overuse headache (58·5 [50·8 to 67·4 million]), and Alzheimer's disease and other dementias (46·0 [40·2 to 52·7 million]). Between 1990 and 2015, the number of deaths from neurological disorders increased by 36·7%, and the number of DALYs by 7·4%. These increases occurred despite decreases in age-standardised rates of death and DALYs of 26·1% and 29·7%, respectively; stroke and communicable neurological disorders were responsible for most of these decreases. Communicable neurological disorders were the largest cause of DALYs in countries with low SDI. Stroke rates were highest at middle levels of SDI and lowest at the highest SDI. Most of the changes in DALY rates of neurological disorders with development were driven by changes in YLLs. Interpretation Neurological disorders are an important cause of disability and death worldwide. Globally, the burden of neurological disorders has increased substantially over the past 25 years because of expanding population numbers and ageing, despite substantial decreases in mortality rates from stroke and communicable neurological disorders. The number of patients who will need care by clinicians with expertise in neurological conditions will continue to grow in coming decades. Policy makers and health-care providers should be aware of these trends to provide adequate services. Funding Bill & Melinda Gates Foundation.

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