((-)-Glasiantarsin, satu dipeptida terbaharu dan beberapa metabolit sekunder daripada yis psikrofilik glaciozyma antarctica PI12)

Translated title of the contribution: (-)-Glaciantarcin, a new dipeptide and some secondary metabolites from the psychrophilic yeast glaciozyma antarctica PI12

Andi R. Rosandy, Yeoh Chiann Ying, Cheah Yoke Kqueen, Seng Joe Lim, Jalifah Latip, A. Munir, Abdul Munir Abd. Murad, Muntaz Abu Bakar, Rozida Mohd. Khalid

Research output: Contribution to journalArticle

Abstract

A new dipeptide, (-)-glaciantarcin (1) and three known compounds, cyclo(-Pro-Gly) (2), 1-(2-deoxypentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione (3) and vidarabine (Ara-A) (4), were isolated from Glaciozyma antarctica PI12, a cold-adapted yeast. The chemical structures were elucidated by FT-IR, NMR and mass spectrometry. The cytotoxicity and antioxidant activities of compounds 1-4 were evaluated by using the MTT bioassay on MCF-7 (human breast cancer cell line), PC-3 (human prostate cancer cell line) and HEK-293 (normal human embryonic kidney cell line) and DPPH free radical scavenging activity, respectively. At concentration of 400 µM, all compounds showed the highest activity on MCF-7, with compound 1 at 65%, compound 2 (70%), compound 3 (66%) and compound 4 (58%) cell viability. All compounds exhibited weak antioxidant properties. To the best of our knowledge, this is the first report of compounds 1-4 from Glaciozyma antactica.

Original languageMalay
Pages (from-to)2693-2698
Number of pages6
JournalSains Malaysiana
Volume47
Issue number11
DOIs
Publication statusPublished - 1 Nov 2018

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Dipeptides
Metabolites
Yeast
Cells
Vidarabine
Antioxidants
Thymine
Bioassay
Scavenging
Cytotoxicity
Free Radicals
Mass spectrometry
Nuclear magnetic resonance

ASJC Scopus subject areas

  • General

Cite this

((-)-Glasiantarsin, satu dipeptida terbaharu dan beberapa metabolit sekunder daripada yis psikrofilik glaciozyma antarctica PI12). / Rosandy, Andi R.; Ying, Yeoh Chiann; Kqueen, Cheah Yoke; Lim, Seng Joe; Latip, Jalifah; Munir, A.; Abd. Murad, Abdul Munir; Abu Bakar, Muntaz; Mohd. Khalid, Rozida.

In: Sains Malaysiana, Vol. 47, No. 11, 01.11.2018, p. 2693-2698.

Research output: Contribution to journalArticle

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AU - Ying, Yeoh Chiann

AU - Kqueen, Cheah Yoke

AU - Lim, Seng Joe

AU - Latip, Jalifah

AU - Munir, A.

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