Ginger (Zingiber officinale Roscoe) in the Prevention of Ageing and Degenerative Diseases

Review of Current Evidence

Nur Fatin Nabilah Mohd Sahardi, Suzana Makpol

Research output: Contribution to journalReview article

Abstract

Currently, the age of the population is increasing as a result of increased life expectancy. Ageing is defined as the progressive loss of physiological integrity, which can be characterized by functional impairment and high vulnerability to various types of diseases, such as diabetes, hypertension, Alzheimer's disease (AD), Parkinson's disease (PD), and atherosclerosis. Numerous studies have reported that the presence of oxidative stress and inflammation contributes to the development of these diseases. In general, oxidative stress could induce proinflammatory cytokines and reduce cellular antioxidant capacity. Increased oxidative stress levels beyond the production of antioxidant agents cause oxidative damage to biological molecules, including DNA, protein, and carbohydrates, which affects normal cell signalling, cell growth, differentiation, and apoptosis and leads to disease pathogenesis. Since oxidative stress and inflammation contribute to these diseases, ginger (Zingiber officinale Roscoe) is one of the potential herbs that can be used to reduce the level of oxidative stress and inflammation. Ginger consists of two major active components, 6-gingerol and 6-shogaol, which are essential for preventing oxidative stress and inflammation. Thus, this paper will review the effects of ginger on ageing and degenerative diseases, including AD, PD, type 2 diabetes mellitus (DM), hypertension, and osteoarthritis.

Original languageEnglish
Article number5054395
JournalEvidence-based Complementary and Alternative Medicine
Volume2019
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Ginger
Oxidative Stress
Inflammation
Alzheimer Disease
Antioxidants
Hypertension
Parkinsonian Disorders
Life Expectancy
Osteoarthritis
Type 2 Diabetes Mellitus
Parkinson Disease
Cell Differentiation
Atherosclerosis
Carbohydrates
Apoptosis
Cytokines
DNA
Growth
Population
Proteins

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Ginger (Zingiber officinale Roscoe) in the Prevention of Ageing and Degenerative Diseases : Review of Current Evidence. / Sahardi, Nur Fatin Nabilah Mohd; Makpol, Suzana.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2019, 5054395, 01.01.2019.

Research output: Contribution to journalReview article

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