Genomic analysis of the causative agents of coccidiosis in domestic chickens

Adam J. Reid, Damer P. Blake, Hifzur R. Ansari, Karen Billington, Hilary P. Browne, Josephine Bryant, Matt Dunn, Stacy S. Hung, Fumiya Kawahara, Diego Miranda-Saavedra, Tareq B. Malas, Tobias Mourier, Hardeep Naghra, Mridul Nair, Thomas D. Otto, Neil D. Rawlings, Pierre Rivailler, Alejandro Sanchez-Flores, Mandy Sanders, Chandra SubramaniamYea Ling Tay, Yong Woo, Xikun Wu, Bart Barrell, Paul H. Dear, Christian Doerig, Arthur Gruber, Alasdair C. Ivens, John Parkinson, Marie Adéle Rajandream, Martin W. Shirley, Kiew Lian Wan, Matthew Berriman, Fiona M. Tomley, Arnab Pain

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Global production of chickens has trebled in the past two decades and they are now the most important source of dietary animal protein worldwide. Chickens are subject to many infectious diseases that reduce their performance and productivity. Coccidiosis, caused by apicomplexan protozoa of the genus Eimeria, is one of the most important poultry diseases. Understanding the biology of Eimeria parasites underpins development of new drugs and vaccines needed to improve global food security. We have produced annotated genome sequences of all seven species of Eimeria that infect domestic chickens, which reveal the full extent of previously described repeat-rich and repeat-poor regions and show that these parasites possess the most repeat-rich proteomes ever described. Furthermore, while no other apicomplexan has been found to possess retrotransposons, Eimeria is home to a family of chromoviruses. Analysis of Eimeria genes involved in basic biology and host-parasite interaction highlights adaptations to a relatively simple developmental life cycle and a complex array of co-expressed surface proteins involved in host cell binding.

Original languageEnglish
Pages (from-to)1676-1685
Number of pages10
JournalGenome Research
Volume24
Issue number10
DOIs
Publication statusPublished - 1 Oct 2014

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Coccidiosis
Eimeria
Chickens
Parasites
Poultry Diseases
Host-Parasite Interactions
Retroelements
Food Supply
Dietary Proteins
Proteome
Life Cycle Stages
Communicable Diseases
Membrane Proteins
Vaccines
Genome
Pharmaceutical Preparations
Genes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Reid, A. J., Blake, D. P., Ansari, H. R., Billington, K., Browne, H. P., Bryant, J., ... Pain, A. (2014). Genomic analysis of the causative agents of coccidiosis in domestic chickens. Genome Research, 24(10), 1676-1685. https://doi.org/10.1101/gr.168955.113

Genomic analysis of the causative agents of coccidiosis in domestic chickens. / Reid, Adam J.; Blake, Damer P.; Ansari, Hifzur R.; Billington, Karen; Browne, Hilary P.; Bryant, Josephine; Dunn, Matt; Hung, Stacy S.; Kawahara, Fumiya; Miranda-Saavedra, Diego; Malas, Tareq B.; Mourier, Tobias; Naghra, Hardeep; Nair, Mridul; Otto, Thomas D.; Rawlings, Neil D.; Rivailler, Pierre; Sanchez-Flores, Alejandro; Sanders, Mandy; Subramaniam, Chandra; Tay, Yea Ling; Woo, Yong; Wu, Xikun; Barrell, Bart; Dear, Paul H.; Doerig, Christian; Gruber, Arthur; Ivens, Alasdair C.; Parkinson, John; Rajandream, Marie Adéle; Shirley, Martin W.; Wan, Kiew Lian; Berriman, Matthew; Tomley, Fiona M.; Pain, Arnab.

In: Genome Research, Vol. 24, No. 10, 01.10.2014, p. 1676-1685.

Research output: Contribution to journalArticle

Reid, AJ, Blake, DP, Ansari, HR, Billington, K, Browne, HP, Bryant, J, Dunn, M, Hung, SS, Kawahara, F, Miranda-Saavedra, D, Malas, TB, Mourier, T, Naghra, H, Nair, M, Otto, TD, Rawlings, ND, Rivailler, P, Sanchez-Flores, A, Sanders, M, Subramaniam, C, Tay, YL, Woo, Y, Wu, X, Barrell, B, Dear, PH, Doerig, C, Gruber, A, Ivens, AC, Parkinson, J, Rajandream, MA, Shirley, MW, Wan, KL, Berriman, M, Tomley, FM & Pain, A 2014, 'Genomic analysis of the causative agents of coccidiosis in domestic chickens', Genome Research, vol. 24, no. 10, pp. 1676-1685. https://doi.org/10.1101/gr.168955.113
Reid AJ, Blake DP, Ansari HR, Billington K, Browne HP, Bryant J et al. Genomic analysis of the causative agents of coccidiosis in domestic chickens. Genome Research. 2014 Oct 1;24(10):1676-1685. https://doi.org/10.1101/gr.168955.113
Reid, Adam J. ; Blake, Damer P. ; Ansari, Hifzur R. ; Billington, Karen ; Browne, Hilary P. ; Bryant, Josephine ; Dunn, Matt ; Hung, Stacy S. ; Kawahara, Fumiya ; Miranda-Saavedra, Diego ; Malas, Tareq B. ; Mourier, Tobias ; Naghra, Hardeep ; Nair, Mridul ; Otto, Thomas D. ; Rawlings, Neil D. ; Rivailler, Pierre ; Sanchez-Flores, Alejandro ; Sanders, Mandy ; Subramaniam, Chandra ; Tay, Yea Ling ; Woo, Yong ; Wu, Xikun ; Barrell, Bart ; Dear, Paul H. ; Doerig, Christian ; Gruber, Arthur ; Ivens, Alasdair C. ; Parkinson, John ; Rajandream, Marie Adéle ; Shirley, Martin W. ; Wan, Kiew Lian ; Berriman, Matthew ; Tomley, Fiona M. ; Pain, Arnab. / Genomic analysis of the causative agents of coccidiosis in domestic chickens. In: Genome Research. 2014 ; Vol. 24, No. 10. pp. 1676-1685.
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