Genome sequence of Streptomyces pluripotens MUSC 135T exhibiting antibacterial and antioxidant activity

Hooi Leng Ser, Wen Si Tan, Nurul Syakima Ab Mutalib, Huey Jia Cheng, Wai Fong Yin, Kok Gan Chan, Learn Han Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Isolated from intertidal soil, Streptomyces pluripotens MUSC 135T produces a broad-spectrum bacteriocin against the pathogens methicillin-resistant Staphylococcus aureus (MRSA) ATCC BAA-44T, Salmonella typhi ATCC 19430T and Aeromonas hydrophila ATCC 7966T. Along with antibacterial activity, fermentation studies on strain MUSC 135T revealed production of antioxidant(s). The high quality draft genome of MUSC 135T comprises 7,480,269bp with G+C content of 70.00%. Through bioinformatics analysis, 72 gene clusters identified in the genome were associated with the production of secondary metabolites, which may shed light on the identity of these bioactive compounds.

Original languageEnglish
Pages (from-to)281-283
Number of pages3
JournalMarine Genomics
Volume24
DOIs
Publication statusPublished - 1 Dec 2015

Fingerprint

Streptomyces
antioxidant
genome
Antioxidants
antioxidant activity
Genome
Aeromonas hydrophila
Salmonella Typhi
Salmonella typhi
Bacteriocins
bioinformatics
secondary metabolite
Base Composition
bacteriocins
Methicillin-Resistant Staphylococcus aureus
Multigene Family
Computational Biology
multigene family
secondary metabolites
Fermentation

Keywords

  • Bacteriocin
  • Genome
  • Methycillin-resistant Staphylococcus aureus
  • MRSA
  • Streptomyces pluripotens

ASJC Scopus subject areas

  • Aquatic Science
  • Genetics

Cite this

Genome sequence of Streptomyces pluripotens MUSC 135T exhibiting antibacterial and antioxidant activity. / Ser, Hooi Leng; Tan, Wen Si; Ab Mutalib, Nurul Syakima; Cheng, Huey Jia; Yin, Wai Fong; Chan, Kok Gan; Lee, Learn Han.

In: Marine Genomics, Vol. 24, 01.12.2015, p. 281-283.

Research output: Contribution to journalArticle

Ser, Hooi Leng ; Tan, Wen Si ; Ab Mutalib, Nurul Syakima ; Cheng, Huey Jia ; Yin, Wai Fong ; Chan, Kok Gan ; Lee, Learn Han. / Genome sequence of Streptomyces pluripotens MUSC 135T exhibiting antibacterial and antioxidant activity. In: Marine Genomics. 2015 ; Vol. 24. pp. 281-283.
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