Genetic alterations of chromosome 8 genes in oral cancer

Zachary Wei Ern Yong, Zuraiza Mohamad Zaini, Thomas George Kallarakkal, Lee Peng Karen-Ng, Zainal Ariff Abdul Rahman, Siti Mazlipah Ismail, Noor Akmal Sharifah, Wan Mahadzir Wan Mustafa, Mannil Thomas Abraham, Keng Kiong Tay, Rosnah Binti Zain

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    The clinical relevance of DNA copy number alterations in chromosome 8 were investigated in oral cancers. The copy numbers of 30 selected genes in 33 OSCC patients were detected using the multiplex ligation-dependent probe amplification (MLPA) technique. Amplifications of the EIF3E gene were found in 27.3% of the patients, MYC in 18.2%, RECQL4 in 15.2% and MYBL1 in 12.1% of patients. The most frequent gene losses found were the GATA4 gene (24.2%), FGFR1 gene (24.2%), MSRA (21.2) and CSGALNACT1 (12.1%). The co-amplification of EIF3E and RECQL4 was found in 9% of patients and showed significant association with alcohol drinkers. There was a significant association between the amplification of EIF3E gene with non-betel quid chewers and the negative lymph node status. EIF3E amplifications did not show prognostic significance on survival. Our results suggest that EIF3E may have a role in the carcinogenesis of OSCC in non-betel quid chewers.

    Original languageEnglish
    Article number6073
    JournalScientific Reports
    Volume4
    DOIs
    Publication statusPublished - 15 Aug 2014

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    Chromosomes, Human, Pair 8
    Mouth Neoplasms
    Gene Amplification
    Genes
    Multiplex Polymerase Chain Reaction
    Carcinogenesis
    Lymph Nodes
    Alcohols
    Survival
    DNA

    ASJC Scopus subject areas

    • General

    Cite this

    Yong, Z. W. E., Zaini, Z. M., Kallarakkal, T. G., Karen-Ng, L. P., Rahman, Z. A. A., Ismail, S. M., ... Zain, R. B. (2014). Genetic alterations of chromosome 8 genes in oral cancer. Scientific Reports, 4, [6073]. https://doi.org/10.1038/srep06073

    Genetic alterations of chromosome 8 genes in oral cancer. / Yong, Zachary Wei Ern; Zaini, Zuraiza Mohamad; Kallarakkal, Thomas George; Karen-Ng, Lee Peng; Rahman, Zainal Ariff Abdul; Ismail, Siti Mazlipah; Sharifah, Noor Akmal; Mustafa, Wan Mahadzir Wan; Abraham, Mannil Thomas; Tay, Keng Kiong; Zain, Rosnah Binti.

    In: Scientific Reports, Vol. 4, 6073, 15.08.2014.

    Research output: Contribution to journalArticle

    Yong, ZWE, Zaini, ZM, Kallarakkal, TG, Karen-Ng, LP, Rahman, ZAA, Ismail, SM, Sharifah, NA, Mustafa, WMW, Abraham, MT, Tay, KK & Zain, RB 2014, 'Genetic alterations of chromosome 8 genes in oral cancer', Scientific Reports, vol. 4, 6073. https://doi.org/10.1038/srep06073
    Yong ZWE, Zaini ZM, Kallarakkal TG, Karen-Ng LP, Rahman ZAA, Ismail SM et al. Genetic alterations of chromosome 8 genes in oral cancer. Scientific Reports. 2014 Aug 15;4. 6073. https://doi.org/10.1038/srep06073
    Yong, Zachary Wei Ern ; Zaini, Zuraiza Mohamad ; Kallarakkal, Thomas George ; Karen-Ng, Lee Peng ; Rahman, Zainal Ariff Abdul ; Ismail, Siti Mazlipah ; Sharifah, Noor Akmal ; Mustafa, Wan Mahadzir Wan ; Abraham, Mannil Thomas ; Tay, Keng Kiong ; Zain, Rosnah Binti. / Genetic alterations of chromosome 8 genes in oral cancer. In: Scientific Reports. 2014 ; Vol. 4.
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