Gene technology for papaya ringspot virus disease management

Md Abul Kalam Azad, Latifah Amin, Nik Marzuki Sidik

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Papaya (Carica papaya) is severely damaged by the papaya ringspot virus (PRSV). This review focuses on the development of PRSV resistant transgenic papaya through gene technology. The genetic diversity of PRSV depends upon geographical distribution and the influence of PRSV disease management on a sequence of PRSV isolates. The concept of pathogen-derived resistance has been employed for the development of transgenic papaya, using a coat protein-mediated, RNA-silencing mechanism and replicase gene-mediated transformation for effective PRSV disease management. The development of PRSV-resistant papaya via post-transcriptional gene silencing is a promising technology for PRSV disease management. PRSV-resistant transgenic papaya is environmentally safe and has no harmful effects on human health. Recent studies have revealed that the success of adoption of transgenic papaya depends upon the application, it being a commercially viable product, bio-safety regulatory issues, trade regulations, and the wider social acceptance of the technology. This review discusses the genome and the genetic diversity of PRSV, host range determinants, molecular diagnosis, disease management strategies, the development of transgenic papaya, environmental issues, issues in the adoption of transgenic papaya, and future directions for research.

Original languageEnglish
Article number768038
JournalThe Scientific World Journal
Volume2014
DOIs
Publication statusPublished - 2014

Fingerprint

Carica
Virus Diseases
Disease Management
Viruses
virus
Genes
Technology
gene
biosafety
Geographical distribution
host range
Capsid Proteins
RNA Interference
Pathogens
environmental issue
geographical distribution
RNA
genome
pathogen
Health

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

Gene technology for papaya ringspot virus disease management. / Azad, Md Abul Kalam; Amin, Latifah; Sidik, Nik Marzuki.

In: The Scientific World Journal, Vol. 2014, 768038, 2014.

Research output: Contribution to journalArticle

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