Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity

Ruby C Y Lin, Sheau Fang Ng, Margaret J. Morris

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Paternal high fat diet (HFD) consumption triggers unique gene signatures, consistent with premature aging and chronic degenerative disorders, in both white adipose tissue (RpWAT) and pancreatic islets of daughters. In addition to published data in Nature, 2010, 467, 963-966 (GSE: 19877, islet) and FASEB J 2014, 28, 1830-1841 (GSE: 33551, RpWAT), we describe here additional details on systems-based approaches and analysis to develop our observations. Our data provides a resource for exploring the complex molecular mechanisms that underlie intergenerational transmission of obesity.

    Original languageEnglish
    Pages (from-to)351-353
    Number of pages3
    JournalGenomics Data
    Volume2
    DOIs
    Publication statusPublished - 2014

    Fingerprint

    Premature Aging
    White Adipose Tissue
    High Fat Diet
    Nutrition
    Islets of Langerhans
    Gene expression
    Rats
    Obesity
    Genes
    Aging of materials
    Fats
    Tissue
    Gene Expression

    Keywords

    • Gene signatures
    • High fat diet
    • Intergenerational transmission
    • Islet dysfunction
    • Paternal transmission

    ASJC Scopus subject areas

    • Molecular Medicine
    • Biochemistry
    • Biotechnology
    • Genetics

    Cite this

    Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity. / Lin, Ruby C Y; Ng, Sheau Fang; Morris, Margaret J.

    In: Genomics Data, Vol. 2, 2014, p. 351-353.

    Research output: Contribution to journalArticle

    Lin, Ruby C Y ; Ng, Sheau Fang ; Morris, Margaret J. / Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity. In: Genomics Data. 2014 ; Vol. 2. pp. 351-353.
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