Gelatine enhances drug dispersion in alginate bilayer film via the formation of crystalline microaggregates

Hnin Ei Thu, Shiow Fern Ng

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

In our previous study, a novel alginate-based bilayer film for slow-release wound dressings was successfully developed. We found that alginate alone yielded poor films; however, the addition of gelatine had significantly enhanced the drug dispersion as well as the physical properties. Here, an investigation of the drug-polymer interactions in the bilayer films was carried out. Drug content uniformity test and microscopy observation revealed that the addition of gelatine generated bilayer films with a homogenous drug distribution within the matrix. The FTIR and XRD data showed an increase in film crystallinity which might infer the presence of drug-polymer crystalline microaggregates in the films. DSC confirmed the drug-polymer interaction and indicated that the gelatine has no effect on the thermal behaviour of the microaggregates, suggesting the compatibility of the drug and excipients in the bilayer films. In conclusion, the addition of gelatine can promote homogenous dispersion of hydrophobic drugs in alginate films possibly through the formation of crystalline microaggregates.

Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume454
Issue number1
DOIs
Publication statusPublished - 2013

Fingerprint

Pharmaceutical Preparations
Polymers
Drug Interactions
Excipients
Fourier Transform Infrared Spectroscopy
Bandages
alginic acid
Microscopy
Hot Temperature
Observation
Wounds and Injuries

Keywords

  • Bilayer films
  • Crystalline microaggregates
  • Gelatine
  • Hydrophobic drug dispersion
  • Sodium alginate

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Gelatine enhances drug dispersion in alginate bilayer film via the formation of crystalline microaggregates. / Thu, Hnin Ei; Ng, Shiow Fern.

In: International Journal of Pharmaceutics, Vol. 454, No. 1, 2013, p. 99-106.

Research output: Contribution to journalArticle

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