Gastroesophageal reflux disease in pregnancy

Raja Affendi Raja Ali, Laurence J. Egan

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Gastroesophageal reflux disease during pregnancy is common. Altered structure and function of the normal physiological barriers to reflux of gastric contents into the oesophagus explain the high incidence of this problem in pregnant women. For the majority of patients, life-style modifications are helpful, but are not sufficient to control symptoms and medication is required. The optimum management of reflux in pregnant patients requires special attention and expertise, since the safety of the mother, foetus and neonate remain the primary focus. Gastroenterologists and obstetricians should work together to optimise treatment. Typically, one utilises a step-up program that starts with life-style modifications and antacids. If those methods fail, histamine-2 receptor antagonists and proton pump inhibitors are tried. Rarely, promotility agents are used. Initiation of these medications must be undertaken after a careful discussion of risks and benefits with patients. In patients without a prior history of reflux, symptoms usually abate after delivery.

Original languageEnglish
Pages (from-to)793-806
Number of pages14
JournalBest Practice and Research: Clinical Gastroenterology
Volume21
Issue number5
DOIs
Publication statusPublished - Oct 2007
Externally publishedYes

Fingerprint

Gastroesophageal Reflux
Pregnancy
Life Style
Histamine Receptors
Antacids
Gastrointestinal Contents
Proton Pump Inhibitors
Esophagus
Pregnant Women
Fetus
Mothers
Newborn Infant
Safety
Incidence
Therapeutics

Keywords

  • gastroesophageal reflux disease
  • heartburn
  • histamine-2 receptor antagonists
  • pregnancy
  • proton pump inhibitors

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Gastroesophageal reflux disease in pregnancy. / Raja Ali, Raja Affendi; Egan, Laurence J.

In: Best Practice and Research: Clinical Gastroenterology, Vol. 21, No. 5, 10.2007, p. 793-806.

Research output: Contribution to journalArticle

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