Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10

Noraziah Mohamad Zin, Mohd Shukri Baba, Abu Hassan Zainal-Abidin, Jalifah Latip, Noor Wini Mazlan, Ru Angelie Edrada-Ebel

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Endophytic Streptomyces strains are potential sources for novel bioactive molecules. In this study, the diketopiperazine gancidin W (GW) was isolated sfrom the endophytic actinobacterial genus Streptomyces, SUK10, obtained from the bark of Shorea ovalis tree, and it was tested in vivo against Plasmodium berghei PZZ1/100. GW exhibited an inhibition rate of nearly 80% at 6.25 and 3.125 µg kg-1 body weight on day four using the 4-day suppression test method on male ICR strain mice. Comparing GW at both concentrations with quinine hydrochloride and normal saline as positive and negative controls, respectively, 50% of the mice treated with 3.125 µg kg-1 body weight managed to survive for more than 11 months after infection, which almost reached the life span of normal mice. Biochemical tests of selected enzymes and proteins in blood samples of mice treated with GW were also within normal levels; in addition, no abnormalities or injuries were found on internal vital organs. These findings indicated that this isolated bioactive compound from Streptomyces SUK10 exhibits very low toxicity and is a good candidate for potential use as an antimalarial agent in an animal model.

Original languageEnglish
Pages (from-to)351-363
Number of pages13
JournalDrug Design, Development and Therapy
Volume11
DOIs
Publication statusPublished - 8 Feb 2017

Fingerprint

Antimalarials
Streptomyces
Dipterocarpaceae
Diketopiperazines
Body Weight
Plasmodium berghei
Inbred ICR Mouse
Quinine
Blood Proteins
Animal Models
Wounds and Injuries
Enzymes
Infection

Keywords

  • Antimalarial
  • Endophytic
  • Gancidin W
  • In vivo
  • Shorea ovalis
  • Streptomyces

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

Cite this

Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10. / Mohamad Zin, Noraziah; Baba, Mohd Shukri; Zainal-Abidin, Abu Hassan; Latip, Jalifah; Mazlan, Noor Wini; Edrada-Ebel, Ru Angelie.

In: Drug Design, Development and Therapy, Vol. 11, 08.02.2017, p. 351-363.

Research output: Contribution to journalArticle

Mohamad Zin, Noraziah ; Baba, Mohd Shukri ; Zainal-Abidin, Abu Hassan ; Latip, Jalifah ; Mazlan, Noor Wini ; Edrada-Ebel, Ru Angelie. / Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10. In: Drug Design, Development and Therapy. 2017 ; Vol. 11. pp. 351-363.
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