Gamma irradiation-assisted synthesis of cellulose nanocrystal-reinforced gelatin hydrogels

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Herein, we describe the use of gamma irradiation to prepare hydrogels comprising α-cellulose and cellulose nanocrystal (CNC)-reinforced gelatin in the absence of crosslinking agents. In this study, cellulose was extracted from rice husks by an alkali and bleaching treatment followed by acid hydrolysis to produce CNC. A semi-interpenetrating network (semi-IPN) of hydrogels was developed by the miscibility between gelatin and cellulosic materials. Compared to those prepared from α-cellulose, hydrogels prepared by dispersion of CNCs exhibited remarkably enhanced stiffness and swelling properties, which was ascribed to the uniform distribution of CNCs and their increased crystallinity. Improved pore structure, arrangement, and rigidity of CNC-reinforced gelatin hydrogels, which induced the swelling mechanism resulting in higher and faster water uptake was observed with a scanning electron microscope (SEM), compared to cellulose-reinforced gelatin hydrogels. Moreover, in vitro drug profiling demonstrated that CNC/gelatin hydrogels exhibit good drug loading/release behavior and are thus suitable for use in drug-delivery applications.

Original languageEnglish
Article number749
JournalNanomaterials
Volume8
Issue number10
DOIs
Publication statusPublished - 1 Oct 2018

Fingerprint

Hydrogels
Gelatin
Cellulose
Nanocrystals
Irradiation
Swelling
Interpenetrating polymer networks
Alkalies
Pore structure
Bleaching
Drug delivery
Rigidity
Pharmaceutical Preparations
Crosslinking
Hydrolysis
Electron microscopes
Solubility
Stiffness
Scanning
Acids

Keywords

  • Cellulose nanocrystal
  • Gelatin
  • Hydrogels
  • Radiation

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Materials Science(all)

Cite this

Gamma irradiation-assisted synthesis of cellulose nanocrystal-reinforced gelatin hydrogels. / Ishak, Wan Hafizi Wan; Ahmad, Ishak; Ramli, Suria; Mohd Amin, Mohd Cairul Iqbal.

In: Nanomaterials, Vol. 8, No. 10, 749, 01.10.2018.

Research output: Contribution to journalArticle

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N2 - Herein, we describe the use of gamma irradiation to prepare hydrogels comprising α-cellulose and cellulose nanocrystal (CNC)-reinforced gelatin in the absence of crosslinking agents. In this study, cellulose was extracted from rice husks by an alkali and bleaching treatment followed by acid hydrolysis to produce CNC. A semi-interpenetrating network (semi-IPN) of hydrogels was developed by the miscibility between gelatin and cellulosic materials. Compared to those prepared from α-cellulose, hydrogels prepared by dispersion of CNCs exhibited remarkably enhanced stiffness and swelling properties, which was ascribed to the uniform distribution of CNCs and their increased crystallinity. Improved pore structure, arrangement, and rigidity of CNC-reinforced gelatin hydrogels, which induced the swelling mechanism resulting in higher and faster water uptake was observed with a scanning electron microscope (SEM), compared to cellulose-reinforced gelatin hydrogels. Moreover, in vitro drug profiling demonstrated that CNC/gelatin hydrogels exhibit good drug loading/release behavior and are thus suitable for use in drug-delivery applications.

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