Fundamentals of the management of non-Hodgkin lymphoma

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The incidence of Non-Hodgkin's lymphomas (NHL) is rising worldwide and if not adequately treated carries a high mortality rate. The pattern and frequency of NHL vary in different populations and geographical regions. It has considerable biologic and clinical heterogeneity and a definitive diagnosis can be made only after histopathogical examination. The histology and the extent of the lymphoma are the major determinants of optimal therapeutic regimen and treatment outcome. Additionally, the overall treatment strategies should be tailored according to medical status and preference of the patient. A holistic approach provided by a multi-disciplinary team of health care professionals is the cornerstone of ensuring successful treatment outcome. Importantly, therapy should be expedited and where possible performed in experienced centers. Patients achieving remission would require long term monitoring for disease recurrence and late effects of cytotoxic chemotherapy and radiotherapy. Hence, clinicians should have a fundamental understanding in the biology and the principles of treatment of NHL. This review provides an evidence-based and systematic approach in designing therapeutic strategies for individual patients with newly diagnosed and relapsed NHL focusing on the common types of NHL with particular reference to the current practice within the local settings. The role of standard and novel therapeutic modalities in treatment will be summarized.

Original languageEnglish
Pages (from-to)333-340
Number of pages8
JournalMedical Journal of Malaysia
Volume64
Issue number4
Publication statusPublished - Dec 2009

Fingerprint

Non-Hodgkin's Lymphoma
Therapeutics
Patient Care Team
Patient Preference
Lymphoma
Histology
Radiotherapy
Recurrence
Drug Therapy
Mortality
Incidence
Population

Keywords

  • Diffuse large B cell lymphoma
  • Follicular lymphoma
  • Non-Hodgkin lymphoma
  • Rituximab

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fundamentals of the management of non-Hodgkin lymphoma. / S. Abdul Wahid, S Fadilah.

In: Medical Journal of Malaysia, Vol. 64, No. 4, 12.2009, p. 333-340.

Research output: Contribution to journalArticle

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