Functional genomics

Hoe Han Goh, Chyan Leong Ng, Kok Keong Loke

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Functional genomics encompasses diverse disciplines in molecular biology and bioinformatics to comprehend the blueprint, regulation, and expression of genetic elements that define the physiology of an organism. The deluge of sequencing data in the postgenomics era has demanded the involvement of computer scientists and mathematicians to create algorithms, analytical software, and databases for the storage, curation, and analysis of biological big data. In this chapter, we discuss on the concept of functional genomics in the context of systems biology and provide examples of its application in human genetic disease studies, molecular crop improvement, and metagenomics for antibiotic discovery. An overview of transcriptomics workflow and experimental considerations is also introduced. Lastly, we present an in-house case study of transcriptomics analysis of an aromatic herbal plant to understand the effect of elicitation on the biosynthesis of volatile organic compounds.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages11-30
Number of pages20
DOIs
Publication statusPublished - 1 Jan 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1102
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Genomics
Metagenomics
Volatile Organic Compounds
Blueprints
Inborn Genetic Diseases
Molecular biology
Systems Biology
Workflow
Biosynthesis
Physiology
Medical Genetics
Bioinformatics
Computational Biology
Crops
Molecular Biology
Software
Databases
Anti-Bacterial Agents
Big data

Keywords

  • Crop genomics
  • Genomic medicine
  • Metagenomics
  • Pharmacogenomics
  • RNA-Seq
  • Sequencing
  • Transcriptomics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Goh, H. H., Ng, C. L., & Loke, K. K. (2018). Functional genomics. In Advances in Experimental Medicine and Biology (pp. 11-30). (Advances in Experimental Medicine and Biology; Vol. 1102). Springer New York LLC. https://doi.org/10.1007/978-3-319-98758-3_2

Functional genomics. / Goh, Hoe Han; Ng, Chyan Leong; Loke, Kok Keong.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. p. 11-30 (Advances in Experimental Medicine and Biology; Vol. 1102).

Research output: Chapter in Book/Report/Conference proceedingChapter

Goh, HH, Ng, CL & Loke, KK 2018, Functional genomics. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1102, Springer New York LLC, pp. 11-30. https://doi.org/10.1007/978-3-319-98758-3_2
Goh HH, Ng CL, Loke KK. Functional genomics. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2018. p. 11-30. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-98758-3_2
Goh, Hoe Han ; Ng, Chyan Leong ; Loke, Kok Keong. / Functional genomics. Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. pp. 11-30 (Advances in Experimental Medicine and Biology).
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