Full factorial experimental design for carbamazepine removal using electrochemical process

A case study of scheming the pathway degradation

Fouad F. Al-Qaim, Zainab H. Mussa, Ali Yuzir, Md. Pauzi Abdullah, Mohamed Rozali Othman

Research output: Contribution to journalArticle

Abstract

Carbamazepine is an antiepileptic drug which is considered one of the persistent compounds detected in Malaysian aquatic environment. In this present study, a full factorial experimental design was applied for the analysis of effect NaCl amount, initial concentration of carbamazepine, applied voltage and treatment time on the electrochemical removal percentage of carbamazepine. However, applied voltage was found as the most significant factor with p = 0.00 lower than 95% confidence level. The investigation of effect NaCl and Na2SO4 on the pathway degradation for carbamazepine was provided using liquid chromatography-time of flight/mass spectrometry (LC-TOF/MS). The results showed that new by-products were identified such chloro-epoxy carbamazepine, and other by-products, were detected in the presence of NaCl and Na2SO4 electrolytes. High inhibition percentage of Escherichia coli (E. coli) bacteria was observed at 24.0 h incubation time for both NaCl and Na2SO4 electrolytes after 80 and 20 min of treatment, respectively. Printed in Brazil-

Original languageEnglish
Pages (from-to)1721-1731
Number of pages11
JournalJournal of the Brazilian Chemical Society
Volume29
Issue number8
DOIs
Publication statusPublished - 1 Aug 2018

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Carbamazepine
Design of experiments
Degradation
Electrolytes
Byproducts
Liquid chromatography
Electric potential
Anticonvulsants
Escherichia coli
Mass spectrometry
Bacteria

Keywords

  • By-product elucidation
  • Electrochemical removal
  • Full factorial experimental design
  • NaCl and NaSO as supporting electrolytes
  • Toxicity evaluation

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

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title = "Full factorial experimental design for carbamazepine removal using electrochemical process: A case study of scheming the pathway degradation",
abstract = "Carbamazepine is an antiepileptic drug which is considered one of the persistent compounds detected in Malaysian aquatic environment. In this present study, a full factorial experimental design was applied for the analysis of effect NaCl amount, initial concentration of carbamazepine, applied voltage and treatment time on the electrochemical removal percentage of carbamazepine. However, applied voltage was found as the most significant factor with p = 0.00 lower than 95{\%} confidence level. The investigation of effect NaCl and Na2SO4 on the pathway degradation for carbamazepine was provided using liquid chromatography-time of flight/mass spectrometry (LC-TOF/MS). The results showed that new by-products were identified such chloro-epoxy carbamazepine, and other by-products, were detected in the presence of NaCl and Na2SO4 electrolytes. High inhibition percentage of Escherichia coli (E. coli) bacteria was observed at 24.0 h incubation time for both NaCl and Na2SO4 electrolytes after 80 and 20 min of treatment, respectively. Printed in Brazil-",
keywords = "By-product elucidation, Electrochemical removal, Full factorial experimental design, NaCl and NaSO as supporting electrolytes, Toxicity evaluation",
author = "Al-Qaim, {Fouad F.} and Mussa, {Zainab H.} and Ali Yuzir and Abdullah, {Md. Pauzi} and Othman, {Mohamed Rozali}",
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AU - Abdullah, Md. Pauzi

AU - Othman, Mohamed Rozali

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N2 - Carbamazepine is an antiepileptic drug which is considered one of the persistent compounds detected in Malaysian aquatic environment. In this present study, a full factorial experimental design was applied for the analysis of effect NaCl amount, initial concentration of carbamazepine, applied voltage and treatment time on the electrochemical removal percentage of carbamazepine. However, applied voltage was found as the most significant factor with p = 0.00 lower than 95% confidence level. The investigation of effect NaCl and Na2SO4 on the pathway degradation for carbamazepine was provided using liquid chromatography-time of flight/mass spectrometry (LC-TOF/MS). The results showed that new by-products were identified such chloro-epoxy carbamazepine, and other by-products, were detected in the presence of NaCl and Na2SO4 electrolytes. High inhibition percentage of Escherichia coli (E. coli) bacteria was observed at 24.0 h incubation time for both NaCl and Na2SO4 electrolytes after 80 and 20 min of treatment, respectively. Printed in Brazil-

AB - Carbamazepine is an antiepileptic drug which is considered one of the persistent compounds detected in Malaysian aquatic environment. In this present study, a full factorial experimental design was applied for the analysis of effect NaCl amount, initial concentration of carbamazepine, applied voltage and treatment time on the electrochemical removal percentage of carbamazepine. However, applied voltage was found as the most significant factor with p = 0.00 lower than 95% confidence level. The investigation of effect NaCl and Na2SO4 on the pathway degradation for carbamazepine was provided using liquid chromatography-time of flight/mass spectrometry (LC-TOF/MS). The results showed that new by-products were identified such chloro-epoxy carbamazepine, and other by-products, were detected in the presence of NaCl and Na2SO4 electrolytes. High inhibition percentage of Escherichia coli (E. coli) bacteria was observed at 24.0 h incubation time for both NaCl and Na2SO4 electrolytes after 80 and 20 min of treatment, respectively. Printed in Brazil-

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