From the front or back door? Quantitative analysis of direct and indirect extractions of ∞-mangostin from mangosteen (Garcinia mangostana)

Edison Eukun Sage, Nashriq Jailani, Azney Zuhaily Md Taib, Normah Mohd. Noor, Md Ikram Mohd Said, Muntaz Abu Bakar, Muhammad Mukram Mohamed Mackeen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The pulp and pericarp of mangosteen (Garcinia mangostana) fruit are popular food, beverage and health products whereby 60% of the fruit consist of the pericarp. The major metabolite in the previously neglected or less economically significant part of the fruit, the pericarp, is the prenylated xanthone ∞-mangostin. This highly bioactive secondary metabolite is typically isolated using solvent extraction methods that involve large volumes of halogenated solvents either via direct or indirect extraction. In this study, we compared the quantities of ∞-mangostin extracted using three different extraction methods based on the environmentally friendly solvents methanol and ethyl acetate. The three solvent extractions methods used were direct extractions from methanol (DM) and ethyl acetate (DEA) as well as indirect extraction of ethyl acetate obtained via solvent partitioning from an initial methanol extract (IEA). Our results showed that direct extraction afforded similar and higher quantities of ∞-mangostin than indirect extraction (DM: 318 mg; DEA: 305 mg; IEA: 209 mg per 5 g total dried pericarp). Therefore, we suggest that the commonly used method of indirect solvent extraction using halogenated solvents for the isolation of ∞-mangostin is replaced by single solvent direct extraction using the environmentally friendly solvents methanol or ethyl acetate.

Original languageEnglish
Article numbere0205753
JournalPLoS One
Volume13
Issue number10
DOIs
Publication statusPublished - 1 Oct 2018

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Garcinia mangostana
Garcinia
mangosteens
quantitative analysis
Methanol
Chemical analysis
Solvent extraction
Fruits
pericarp
methanol
Metabolites
Fruit
fruits
Beverages
mangostin
Food and Beverages
xanthone
Pulp
extracts
ethyl acetate

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

From the front or back door? Quantitative analysis of direct and indirect extractions of ∞-mangostin from mangosteen (Garcinia mangostana). / Sage, Edison Eukun; Jailani, Nashriq; Taib, Azney Zuhaily Md; Mohd. Noor, Normah; Ikram Mohd Said, Md; Abu Bakar, Muntaz; Mohamed Mackeen, Muhammad Mukram.

In: PLoS One, Vol. 13, No. 10, e0205753, 01.10.2018.

Research output: Contribution to journalArticle

Sage, Edison Eukun ; Jailani, Nashriq ; Taib, Azney Zuhaily Md ; Mohd. Noor, Normah ; Ikram Mohd Said, Md ; Abu Bakar, Muntaz ; Mohamed Mackeen, Muhammad Mukram. / From the front or back door? Quantitative analysis of direct and indirect extractions of ∞-mangostin from mangosteen (Garcinia mangostana). In: PLoS One. 2018 ; Vol. 13, No. 10.
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