Frequency of the HLA-B*1502 allele contributing to carbamazepine-induced hypersensitivity reactions in a cohort of Malaysian epilepsy patients

Sue Mian Then, Zam Zureena Mohd Rani, Raymond Azman Ali, Safrina Ratnaningrum, A. Rahman A. Jamal

Research output: Contribution to journalArticle

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Abstract

We describe the association of the HLAB* 1502 allele in 27 epilepsy patients (19 Malays, 8 Chinese) treated with carbamazepine (CBZ) at the UKM Medical Center (UKMMC), 6 with CBZ-Steven Johnson Syndrome (CBZ-SJS), 11 with CBZ-induced rash, 2 with suspected phenytoin-induced rash and 8 negative controls. Our study showed that 10 (6 Malay, 4 Chinese) patients were positive for HLA-B*1502. Out of the 10 patients, six were confirmed to have CBZSJS (p =0.0006), while four patients developed a skin rash. However there were 6 Malay patients and 1 Chinese patient that developed a skin rash after CBZ administration who were not positive for the allele, indicating that there might be more that one allele associated with CBZ-induced hypersensitivity. Another 2 patients were suspected of having phenytoin-induced rash, instead of CBZ, and these patients did not have HLA-B*1502. In conclusion, this study confirmed the association of HLA-B*1502 with CBZ-SJS among Malaysian epilepsy patients, however there might be other genes that could be responsible for the CBZ-induced rash.

Original languageEnglish
Pages (from-to)290-293
Number of pages4
JournalAsian Pacific Journal of Allergy and Immunology
Volume29
Issue number3
Publication statusPublished - 2011

Fingerprint

HLA-B Antigens
Carbamazepine
Epilepsy
Hypersensitivity
Alleles
Exanthema
Phenytoin
Stevens-Johnson Syndrome

Keywords

  • Carbamazepine
  • Drug hypersensitivity
  • Epilepsy
  • HLA-B*1502 allele
  • Pharmacogenomics
  • Steve-Johnson syndrome

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Frequency of the HLA-B*1502 allele contributing to carbamazepine-induced hypersensitivity reactions in a cohort of Malaysian epilepsy patients. / Then, Sue Mian; Rani, Zam Zureena Mohd; Ali, Raymond Azman; Ratnaningrum, Safrina; A. Jamal, A. Rahman.

In: Asian Pacific Journal of Allergy and Immunology, Vol. 29, No. 3, 2011, p. 290-293.

Research output: Contribution to journalArticle

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