Frequencies of glutathione s-transferase (GSTM1, GSTM3 and GSTT1) polymorphisms in a Malaysian population

Mustafa A. Alshagga, Norazlina Mohamed, Ahmad Nazrun Suhid, Ibrahim Abdel Aziz Ibrahim, Syed Zulkifli Syed Zakaria

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Introduction: Glutathione S-transferase (GST) is a xenobiotic metabolising enzyme (XME), which may modify susceptibility in certain ethnic groups, showing ethnic dependent polymorphism. The aim of this study was to determine GSTM1, GSTM3 and GSTT1 gene polymorphisms in a Malaysian population in Kuala Lumpur. Material and methods: Blood or buccal swab samples were collected from 137 Form II students from three schools in Wilayah Persekutuan Kuala Lumpur. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Glutathione-S-transferase GSTM3 gene frequencies were 89% for AA, 10% for AB and 1% for BB. The gene frequencies for deleted GSTM1 and GSTT1 were 66% and 18% respectively. Conclusions: This study suggested that the Malay population is at risk for environmental diseases and provides the basis for gene-environment association studies to be carried out.

Original languageEnglish
Pages (from-to)572-578
Number of pages7
JournalArchives of Medical Science
Volume7
Issue number4
DOIs
Publication statusPublished - Aug 2011

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Glutathione Transferase
Gene Frequency
Cheek
Xenobiotics
Ethnic Groups
Restriction Fragment Length Polymorphisms
Population
Genes
Students
Polymerase Chain Reaction
Enzymes

Keywords

  • Gene
  • Glutathione s-transferase
  • Malaysians
  • Polymorphism

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Frequencies of glutathione s-transferase (GSTM1, GSTM3 and GSTT1) polymorphisms in a Malaysian population. / Alshagga, Mustafa A.; Mohamed, Norazlina; Suhid, Ahmad Nazrun; Ibrahim, Ibrahim Abdel Aziz; Syed Zakaria, Syed Zulkifli.

In: Archives of Medical Science, Vol. 7, No. 4, 08.2011, p. 572-578.

Research output: Contribution to journalArticle

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