Formulation screening of palm-based nanoemulsion for an oral drug vehicle of phyllanthin

Nurin Afiqah Zairul Azman, Ismail Ab Raman, Ibrahim Jantan, Darfizzi Derawi

Research output: Contribution to journalArticle

Abstract

Phyllanthus amarus is commonly used in traditional medicine, and the major lignins of the plant, namely, phyllanthin and hypophyllanthin, have been reported to possess hepatoprotective activity. However, phyllanthin exhibits low oral bioavailability and requires a large quantity of herbal extract for a longer duration of treatment, limiting the clinical use of phyllanthin. To overcome these drawbacks, nano-sized emulsion systems have gained increasing importance due to their ability to improve the gastrointestinal absorption of hydrophobic drugs. Proper selection of oils and surfactants, along with their suitable hydrophilic-lipophilic balance (HLB) value, is crucial to obtain stable, mild and clinically acceptable nanoemulsions. The focus of the present study is to provide an efficient screening approach for the excipient selection for the optimum nanoemulsion formulation development containing phyllanthin. The selection of oil was based on the solubilizing capacity of phyllanthin by HPLC analysis. The drug solubility in the oil was taken as the criterion for oil selection, and palm kernel oil ester was chosen as the oil phase in the nanoemulsion formulation. Emulsification ability of the surfactant was assessed for surfactant screening. Among them, Tween® 80 and Span® 80 were found to be an effective emulsifier for the oil phase. The desired HLB value for oil-in-water nanoemulsion is between 8 and 18. The nanoemulsion formulation was thermally stable and could be effectively used for drug delivery applications.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalMalaysian Journal of Chemistry
Volume21
Issue number2
Publication statusPublished - 1 Jan 2019

Fingerprint

Screening
Oils
Pharmaceutical Preparations
Surface-Active Agents
Surface active agents
Palm oil
Emulsification
Polysorbates
Lignin
Excipients
phyllanthin
Emulsions
Drug delivery
Medicine
Esters
Solubility
Water

Keywords

  • Nanoemulsion
  • Nonionic surfactant
  • Palm-based oil
  • Phyllanthin
  • Phyllanthus amarus
  • Screening

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

Cite this

Formulation screening of palm-based nanoemulsion for an oral drug vehicle of phyllanthin. / Azman, Nurin Afiqah Zairul; Raman, Ismail Ab; Jantan, Ibrahim; Derawi, Darfizzi.

In: Malaysian Journal of Chemistry, Vol. 21, No. 2, 01.01.2019, p. 43-49.

Research output: Contribution to journalArticle

Azman, Nurin Afiqah Zairul ; Raman, Ismail Ab ; Jantan, Ibrahim ; Derawi, Darfizzi. / Formulation screening of palm-based nanoemulsion for an oral drug vehicle of phyllanthin. In: Malaysian Journal of Chemistry. 2019 ; Vol. 21, No. 2. pp. 43-49.
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