Formulation optimization of a palm-based nanoemulsion system containing levodopa

Syafinaz Zainol, Mahiran Basri, Hamidon Bin Basri, Ahmad Fuad Shamsuddin, Siti Salwa Abdul-Gani, Roghayeh Abedi Karjiban, Emilia Abdul-Malek

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Response surface methodology (RSM) was utilized to investigate the influence of the main emulsion composition; mixture of palm and medium-chain triglyceride (MCT) oil (6%-12% w/w), lecithin (1%-3% w/w), and Cremophor EL (0.5%-1.5% w/w) as well as the preparation method; addition rate (2-20 mL/min), on the physicochemical properties of palm-based nanoemulsions. The response variables were the three main emulsion properties; particle size, zeta potential and polydispersity index. Optimization of the four independent variables was carried out to obtain an optimum level palm-based nanoemulsion with desirable characteristics. The response surface analysis showed that the variation in the three responses could be depicted as a quadratic function of the main composition of the emulsion and the preparation method. The experimental data could be fitted sufficiently well into a second-order polynomial model. The optimized formulation was stable for six months at 4 °C.

Original languageEnglish
Pages (from-to)13049-13064
Number of pages16
JournalInternational Journal of Molecular Sciences
Volume13
Issue number10
DOIs
Publication statusPublished - Oct 2012

Fingerprint

Levodopa
Emulsions
emulsions
formulations
optimization
Lecithin
Lecithins
Surface analysis
Polydispersity
Statistical Models
Zeta potential
Chemical analysis
Particle Size
preparation
Oils
Triglycerides
Particle size
polynomials
oils
methodology

Keywords

  • Central composite design
  • Levodopa
  • Nanoemulsions
  • Palm oil
  • Response surface methodology

ASJC Scopus subject areas

  • Computer Science Applications
  • Molecular Biology
  • Catalysis
  • Inorganic Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Physical and Theoretical Chemistry

Cite this

Zainol, S., Basri, M., Basri, H. B., Shamsuddin, A. F., Abdul-Gani, S. S., Karjiban, R. A., & Abdul-Malek, E. (2012). Formulation optimization of a palm-based nanoemulsion system containing levodopa. International Journal of Molecular Sciences, 13(10), 13049-13064. https://doi.org/10.3390/ijms131013049

Formulation optimization of a palm-based nanoemulsion system containing levodopa. / Zainol, Syafinaz; Basri, Mahiran; Basri, Hamidon Bin; Shamsuddin, Ahmad Fuad; Abdul-Gani, Siti Salwa; Karjiban, Roghayeh Abedi; Abdul-Malek, Emilia.

In: International Journal of Molecular Sciences, Vol. 13, No. 10, 10.2012, p. 13049-13064.

Research output: Contribution to journalArticle

Zainol, S, Basri, M, Basri, HB, Shamsuddin, AF, Abdul-Gani, SS, Karjiban, RA & Abdul-Malek, E 2012, 'Formulation optimization of a palm-based nanoemulsion system containing levodopa', International Journal of Molecular Sciences, vol. 13, no. 10, pp. 13049-13064. https://doi.org/10.3390/ijms131013049
Zainol, Syafinaz ; Basri, Mahiran ; Basri, Hamidon Bin ; Shamsuddin, Ahmad Fuad ; Abdul-Gani, Siti Salwa ; Karjiban, Roghayeh Abedi ; Abdul-Malek, Emilia. / Formulation optimization of a palm-based nanoemulsion system containing levodopa. In: International Journal of Molecular Sciences. 2012 ; Vol. 13, No. 10. pp. 13049-13064.
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