Formulation and physical characterization of microemulsions containing isotretinoin

Suria Ramli, Benjamin P. Ross, Ian R. Gentle

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

Physical properties of microemulsions containing tween80 as surfactant and tetraglycol as cosurfactant, were investigated for their potential to form microemulsion templates as drug delivery vehicles for isotretinoin. Bile salt was used as edge activator in skin permeation and surfactant protein B (SP-B1-25) may be helpful in drug delivery and reducing sebum level. All of the compounds used to formulate the microemulsions were pharmaceutically acceptable and biocompatible. The drug-containing systems were characterized in regard to their transdermal parameters. Physiologically well-tolerated and physically stable multiple-component systems were developed. The concentrations of surfactants and cosurfactants which are necessary to form stable systems were evaluated. Microemulsions were characterized using polarized light microscopy, photon correlation spectroscopy (PCS), electric conductivity and rheometry. The influence of isotretinoin on the physical parameters of the preparation was investigated.

Original languageEnglish
Title of host publication2nd International Conference on Biomedical and Pharmaceutical Engineering, ICBPE 2009 - Conference Proceedings
DOIs
Publication statusPublished - 2009
Externally publishedYes
Event2nd International Conference on Biomedical and Pharmaceutical Engineering, ICBPE 2009 - Singapore
Duration: 2 Dec 20094 Dec 2009

Other

Other2nd International Conference on Biomedical and Pharmaceutical Engineering, ICBPE 2009
CitySingapore
Period2/12/094/12/09

Fingerprint

Isotretinoin
Microemulsions
Surface-Active Agents
Surface active agents
Pulmonary Surfactant-Associated Protein B
Drug delivery
Pharmaceutical Preparations
Sebum
Polarization Microscopy
Electric Conductivity
Photon correlation spectroscopy
Bile Acids and Salts
Photons
Spectrum Analysis
Light polarization
Permeation
Optical microscopy
Skin
Physical properties
Salts

Keywords

  • Electrical conductivity
  • Isotretinoin
  • Microemulsion
  • Stability
  • Viscosity

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine(all)

Cite this

Ramli, S., Ross, B. P., & Gentle, I. R. (2009). Formulation and physical characterization of microemulsions containing isotretinoin. In 2nd International Conference on Biomedical and Pharmaceutical Engineering, ICBPE 2009 - Conference Proceedings [5384088] https://doi.org/10.1109/ICBPE.2009.5384088

Formulation and physical characterization of microemulsions containing isotretinoin. / Ramli, Suria; Ross, Benjamin P.; Gentle, Ian R.

2nd International Conference on Biomedical and Pharmaceutical Engineering, ICBPE 2009 - Conference Proceedings. 2009. 5384088.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ramli, S, Ross, BP & Gentle, IR 2009, Formulation and physical characterization of microemulsions containing isotretinoin. in 2nd International Conference on Biomedical and Pharmaceutical Engineering, ICBPE 2009 - Conference Proceedings., 5384088, 2nd International Conference on Biomedical and Pharmaceutical Engineering, ICBPE 2009, Singapore, 2/12/09. https://doi.org/10.1109/ICBPE.2009.5384088
Ramli S, Ross BP, Gentle IR. Formulation and physical characterization of microemulsions containing isotretinoin. In 2nd International Conference on Biomedical and Pharmaceutical Engineering, ICBPE 2009 - Conference Proceedings. 2009. 5384088 https://doi.org/10.1109/ICBPE.2009.5384088
Ramli, Suria ; Ross, Benjamin P. ; Gentle, Ian R. / Formulation and physical characterization of microemulsions containing isotretinoin. 2nd International Conference on Biomedical and Pharmaceutical Engineering, ICBPE 2009 - Conference Proceedings. 2009.
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