Formulasi dan Sifat Fizikal Mikroemulsi Berasaskan Karboksimetil Selulosa sebagai Pembawa Vitamin C

Translated title of the contribution: Formulation and physical characterization of microemulsions based carboxymethyl cellulose as vitamin c carrier

Suria Ramli, Safiah Mohd Ja’Afar, Muhd Asri Abd Sisak, Norhidayu Zainuddin, Irman Abdul Rahman

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The main purpose of this research is to develop a cellulose derivative based microemulsion for transdermal delivery system. In this research, cellulose derivative used is carboxymethyl cellulose (CMC) that was converted from cellulose by etherification reaction and analysed by FTIR instrument. The degree of substitution (DS) for carboxymethyl cellulose is 0.492. Microemulsion system consists of oleic acid as oil phase, Tween 20 as surfactant and propylene glycol as co-surfactant. The active ingredient used in this system is vitamin C. Determination of microemulsion area in the ternary phase diagram was done by titration method. From the result, microemulsion system with surfactant/co-surfactant ratio (Km=3:1) produced the largest surface area in the ternary phase diagram. Microemulsions with and without vitamin C and CMC were characterized using dynamic light scattering (DLS), electrical conductivity and rheometer. For size particle analysis, system without vitamin C and CMC have microemulsion droplet size between 20-200 nm. Based on the electrical conductivity and viscosity test, phase transition occurred in the microemulsion system from water-in-oil (w/o) to bicontinuos phase at 20 wt. % water percentage. The stability test showed microemulsion systems with the percentage of water up to 30 wt. % were stable at temperatures 4 °C, 25 °C and 40 °C upon three weeks storage.

Original languageUndefined/Unknown
Pages (from-to)275-283
Number of pages9
JournalMalaysian Journal of Analytical Sciences
Volume19
Issue number1
Publication statusPublished - 2015

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Carboxymethylcellulose Sodium
Microemulsions
Vitamins
Surface-Active Agents
Ascorbic Acid
Cellulose derivatives
Phase diagrams
Water
Oils
Propylene Glycol
Polysorbates
Rheometers
Dynamic light scattering
Oleic Acid
Titration
Cellulose
Particle size analysis
Substitution reactions
Phase transitions
Viscosity

Keywords

  • Carboxymethyl cellulose
  • Microemulsions
  • Ternary phase diagram
  • Vitamin C

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Formulasi dan Sifat Fizikal Mikroemulsi Berasaskan Karboksimetil Selulosa sebagai Pembawa Vitamin C. / Ramli, Suria; Ja’Afar, Safiah Mohd; Sisak, Muhd Asri Abd; Zainuddin, Norhidayu; Abdul Rahman, Irman.

In: Malaysian Journal of Analytical Sciences, Vol. 19, No. 1, 2015, p. 275-283.

Research output: Contribution to journalArticle

Ramli, Suria ; Ja’Afar, Safiah Mohd ; Sisak, Muhd Asri Abd ; Zainuddin, Norhidayu ; Abdul Rahman, Irman. / Formulasi dan Sifat Fizikal Mikroemulsi Berasaskan Karboksimetil Selulosa sebagai Pembawa Vitamin C. In: Malaysian Journal of Analytical Sciences. 2015 ; Vol. 19, No. 1. pp. 275-283.
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