Focused review

Cytotoxic and antioxidant potentials of mangrove-derived streptomyces

Hooi Leng Ser, Loh Teng Hern Tan, Jodi Woan Fei Law, Kok Gan Chan, Acharaporn Duangjai, Surasak Saokaew, Priyia Pusparajah, Nurul Syakima Ab Mutalib, Tahir Mehmood Khan, Bey Hing Goh, Learn Han Lee

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Human life expectancy is rapidly increasing with an associated increasing burden of chronic diseases, such as neurodegenerative diseases and cancer. However, there is limited progress in finding effective treatment for these conditions. For this reason, members of the genus Streptomyces have been explored extensively over the past decades as these filamentous bacteria are highly efficient in producing bioactive compounds with human health benefits. Being ubiquitous in nature, streptomycetes can be found in both terrestrial and marine environments. Previously, two Streptomyces strains (MUSC 137T and MUM 256) isolated from mangrove sediments in Peninsular Malaysia demonstrated potent antioxidant and cytotoxic activities against several human cancer cell lines on bioactivity screening. These results illustrate the importance of streptomycetes from underexplored regions aside from the terrestrial ecosystem. Here we provide the insights and significance of Streptomyces species in the search of anticancer and/or chemopreventive agents and highlight the impact of next generation sequencing on drug discovery from the Streptomyces arsenal.

Original languageEnglish
Article number2065
JournalFrontiers in Microbiology
Volume8
Issue numberNOV
DOIs
Publication statusPublished - 1 Nov 2017

Fingerprint

Streptomyces
Antioxidants
Malaysia
Insurance Benefits
Drug Discovery
Life Expectancy
Neurodegenerative Diseases
Ecosystem
Neoplasms
Chronic Disease
Bacteria
Cell Line

Keywords

  • Antioxidant
  • Bioactive
  • Cytotoxic
  • Mangrove
  • Streptomyces

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Ser, H. L., Tan, L. T. H., Law, J. W. F., Chan, K. G., Duangjai, A., Saokaew, S., ... Lee, L. H. (2017). Focused review: Cytotoxic and antioxidant potentials of mangrove-derived streptomyces. Frontiers in Microbiology, 8(NOV), [2065]. https://doi.org/10.3389/fmicb.2017.02065

Focused review : Cytotoxic and antioxidant potentials of mangrove-derived streptomyces. / Ser, Hooi Leng; Tan, Loh Teng Hern; Law, Jodi Woan Fei; Chan, Kok Gan; Duangjai, Acharaporn; Saokaew, Surasak; Pusparajah, Priyia; Ab Mutalib, Nurul Syakima; Khan, Tahir Mehmood; Goh, Bey Hing; Lee, Learn Han.

In: Frontiers in Microbiology, Vol. 8, No. NOV, 2065, 01.11.2017.

Research output: Contribution to journalReview article

Ser, HL, Tan, LTH, Law, JWF, Chan, KG, Duangjai, A, Saokaew, S, Pusparajah, P, Ab Mutalib, NS, Khan, TM, Goh, BH & Lee, LH 2017, 'Focused review: Cytotoxic and antioxidant potentials of mangrove-derived streptomyces', Frontiers in Microbiology, vol. 8, no. NOV, 2065. https://doi.org/10.3389/fmicb.2017.02065
Ser, Hooi Leng ; Tan, Loh Teng Hern ; Law, Jodi Woan Fei ; Chan, Kok Gan ; Duangjai, Acharaporn ; Saokaew, Surasak ; Pusparajah, Priyia ; Ab Mutalib, Nurul Syakima ; Khan, Tahir Mehmood ; Goh, Bey Hing ; Lee, Learn Han. / Focused review : Cytotoxic and antioxidant potentials of mangrove-derived streptomyces. In: Frontiers in Microbiology. 2017 ; Vol. 8, No. NOV.
@article{7854191db86e445db0049cacdb6a73e2,
title = "Focused review: Cytotoxic and antioxidant potentials of mangrove-derived streptomyces",
abstract = "Human life expectancy is rapidly increasing with an associated increasing burden of chronic diseases, such as neurodegenerative diseases and cancer. However, there is limited progress in finding effective treatment for these conditions. For this reason, members of the genus Streptomyces have been explored extensively over the past decades as these filamentous bacteria are highly efficient in producing bioactive compounds with human health benefits. Being ubiquitous in nature, streptomycetes can be found in both terrestrial and marine environments. Previously, two Streptomyces strains (MUSC 137T and MUM 256) isolated from mangrove sediments in Peninsular Malaysia demonstrated potent antioxidant and cytotoxic activities against several human cancer cell lines on bioactivity screening. These results illustrate the importance of streptomycetes from underexplored regions aside from the terrestrial ecosystem. Here we provide the insights and significance of Streptomyces species in the search of anticancer and/or chemopreventive agents and highlight the impact of next generation sequencing on drug discovery from the Streptomyces arsenal.",
keywords = "Antioxidant, Bioactive, Cytotoxic, Mangrove, Streptomyces",
author = "Ser, {Hooi Leng} and Tan, {Loh Teng Hern} and Law, {Jodi Woan Fei} and Chan, {Kok Gan} and Acharaporn Duangjai and Surasak Saokaew and Priyia Pusparajah and {Ab Mutalib}, {Nurul Syakima} and Khan, {Tahir Mehmood} and Goh, {Bey Hing} and Lee, {Learn Han}",
year = "2017",
month = "11",
day = "1",
doi = "10.3389/fmicb.2017.02065",
language = "English",
volume = "8",
journal = "Frontiers in Microbiology",
issn = "1664-302X",
publisher = "Frontiers Media S. A.",
number = "NOV",

}

TY - JOUR

T1 - Focused review

T2 - Cytotoxic and antioxidant potentials of mangrove-derived streptomyces

AU - Ser, Hooi Leng

AU - Tan, Loh Teng Hern

AU - Law, Jodi Woan Fei

AU - Chan, Kok Gan

AU - Duangjai, Acharaporn

AU - Saokaew, Surasak

AU - Pusparajah, Priyia

AU - Ab Mutalib, Nurul Syakima

AU - Khan, Tahir Mehmood

AU - Goh, Bey Hing

AU - Lee, Learn Han

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Human life expectancy is rapidly increasing with an associated increasing burden of chronic diseases, such as neurodegenerative diseases and cancer. However, there is limited progress in finding effective treatment for these conditions. For this reason, members of the genus Streptomyces have been explored extensively over the past decades as these filamentous bacteria are highly efficient in producing bioactive compounds with human health benefits. Being ubiquitous in nature, streptomycetes can be found in both terrestrial and marine environments. Previously, two Streptomyces strains (MUSC 137T and MUM 256) isolated from mangrove sediments in Peninsular Malaysia demonstrated potent antioxidant and cytotoxic activities against several human cancer cell lines on bioactivity screening. These results illustrate the importance of streptomycetes from underexplored regions aside from the terrestrial ecosystem. Here we provide the insights and significance of Streptomyces species in the search of anticancer and/or chemopreventive agents and highlight the impact of next generation sequencing on drug discovery from the Streptomyces arsenal.

AB - Human life expectancy is rapidly increasing with an associated increasing burden of chronic diseases, such as neurodegenerative diseases and cancer. However, there is limited progress in finding effective treatment for these conditions. For this reason, members of the genus Streptomyces have been explored extensively over the past decades as these filamentous bacteria are highly efficient in producing bioactive compounds with human health benefits. Being ubiquitous in nature, streptomycetes can be found in both terrestrial and marine environments. Previously, two Streptomyces strains (MUSC 137T and MUM 256) isolated from mangrove sediments in Peninsular Malaysia demonstrated potent antioxidant and cytotoxic activities against several human cancer cell lines on bioactivity screening. These results illustrate the importance of streptomycetes from underexplored regions aside from the terrestrial ecosystem. Here we provide the insights and significance of Streptomyces species in the search of anticancer and/or chemopreventive agents and highlight the impact of next generation sequencing on drug discovery from the Streptomyces arsenal.

KW - Antioxidant

KW - Bioactive

KW - Cytotoxic

KW - Mangrove

KW - Streptomyces

UR - http://www.scopus.com/inward/record.url?scp=85032725312&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032725312&partnerID=8YFLogxK

U2 - 10.3389/fmicb.2017.02065

DO - 10.3389/fmicb.2017.02065

M3 - Review article

VL - 8

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

SN - 1664-302X

IS - NOV

M1 - 2065

ER -