Focal uptake at the rotator interval or inferior capsule of shoulder on 18F-FDG PET/CT is associated with adhesive capsulitis

Radhika Sridharan, Mitchell Philip Engle, Naveen Garg, Wei Wei, Behrang Amini

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To determine if focal increased uptake at the rotator interval (RI) and/or inferior capsule (IC) on18F-FDG PET/CT (“positive PET”) predicts the presence of adhesive capsulitis (AC). Materials and methods: Three populations were retrospectively examined. Group 1 included 1,137 consecutive 18F-FDG PET/CT studies and was used to determine the prevalence of focal uptake at the RI or IC. Group 2 included 361 cases from a 10-year period with 18F-FDG PET/CT and MRI of shoulder performed within 45 days of each other and was used to enrich the study group. Group 3 included 109 randomly selected patients from the same time frame as groups 1 and 2 and was used to generate the control group. The study group consisted of 15 cases from the three groups, which had positive PET findings. PET/CT images were assessed in consensus by two musculoskeletal radiologists. The reference standard for a diagnosis of AC was clinical and was made by review of the medical record by a pain medicine physician. Results: The prevalence of focal activity at either the RI or IC (“positive PET”) was 0.53%. Nine patients had a clinical diagnosis of AC and 15 patients had a positive PET. The sensitivity and specificity of PET for detection of AC was 56% and 87%, respectively. PET/CT had a positive likelihood ratio for AC of 6.3 (95% CI: 2.8–14.6). Conclusions: Increased uptake at the RI or IC on PET/CT confers a moderate increase in the likelihood of AC.

Original languageEnglish
Pages (from-to)533-538
Number of pages6
JournalSkeletal Radiology
Volume46
Issue number4
DOIs
Publication statusPublished - 1 Apr 2017

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Bursitis
Fluorodeoxyglucose F18
Capsules
Medical Records
Consensus
Medicine
Physicians
Sensitivity and Specificity
Pain
Control Groups
Population

Keywords

  • Adhesive capsulitis
  • FDG PET/CT
  • Inferior capsule
  • Rotator interval

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Focal uptake at the rotator interval or inferior capsule of shoulder on 18F-FDG PET/CT is associated with adhesive capsulitis. / Sridharan, Radhika; Engle, Mitchell Philip; Garg, Naveen; Wei, Wei; Amini, Behrang.

In: Skeletal Radiology, Vol. 46, No. 4, 01.04.2017, p. 533-538.

Research output: Contribution to journalArticle

Sridharan, Radhika ; Engle, Mitchell Philip ; Garg, Naveen ; Wei, Wei ; Amini, Behrang. / Focal uptake at the rotator interval or inferior capsule of shoulder on 18F-FDG PET/CT is associated with adhesive capsulitis. In: Skeletal Radiology. 2017 ; Vol. 46, No. 4. pp. 533-538.
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abstract = "Objective: To determine if focal increased uptake at the rotator interval (RI) and/or inferior capsule (IC) on18F-FDG PET/CT (“positive PET”) predicts the presence of adhesive capsulitis (AC). Materials and methods: Three populations were retrospectively examined. Group 1 included 1,137 consecutive 18F-FDG PET/CT studies and was used to determine the prevalence of focal uptake at the RI or IC. Group 2 included 361 cases from a 10-year period with 18F-FDG PET/CT and MRI of shoulder performed within 45 days of each other and was used to enrich the study group. Group 3 included 109 randomly selected patients from the same time frame as groups 1 and 2 and was used to generate the control group. The study group consisted of 15 cases from the three groups, which had positive PET findings. PET/CT images were assessed in consensus by two musculoskeletal radiologists. The reference standard for a diagnosis of AC was clinical and was made by review of the medical record by a pain medicine physician. Results: The prevalence of focal activity at either the RI or IC (“positive PET”) was 0.53{\%}. Nine patients had a clinical diagnosis of AC and 15 patients had a positive PET. The sensitivity and specificity of PET for detection of AC was 56{\%} and 87{\%}, respectively. PET/CT had a positive likelihood ratio for AC of 6.3 (95{\%} CI: 2.8–14.6). Conclusions: Increased uptake at the RI or IC on PET/CT confers a moderate increase in the likelihood of AC.",
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N2 - Objective: To determine if focal increased uptake at the rotator interval (RI) and/or inferior capsule (IC) on18F-FDG PET/CT (“positive PET”) predicts the presence of adhesive capsulitis (AC). Materials and methods: Three populations were retrospectively examined. Group 1 included 1,137 consecutive 18F-FDG PET/CT studies and was used to determine the prevalence of focal uptake at the RI or IC. Group 2 included 361 cases from a 10-year period with 18F-FDG PET/CT and MRI of shoulder performed within 45 days of each other and was used to enrich the study group. Group 3 included 109 randomly selected patients from the same time frame as groups 1 and 2 and was used to generate the control group. The study group consisted of 15 cases from the three groups, which had positive PET findings. PET/CT images were assessed in consensus by two musculoskeletal radiologists. The reference standard for a diagnosis of AC was clinical and was made by review of the medical record by a pain medicine physician. Results: The prevalence of focal activity at either the RI or IC (“positive PET”) was 0.53%. Nine patients had a clinical diagnosis of AC and 15 patients had a positive PET. The sensitivity and specificity of PET for detection of AC was 56% and 87%, respectively. PET/CT had a positive likelihood ratio for AC of 6.3 (95% CI: 2.8–14.6). Conclusions: Increased uptake at the RI or IC on PET/CT confers a moderate increase in the likelihood of AC.

AB - Objective: To determine if focal increased uptake at the rotator interval (RI) and/or inferior capsule (IC) on18F-FDG PET/CT (“positive PET”) predicts the presence of adhesive capsulitis (AC). Materials and methods: Three populations were retrospectively examined. Group 1 included 1,137 consecutive 18F-FDG PET/CT studies and was used to determine the prevalence of focal uptake at the RI or IC. Group 2 included 361 cases from a 10-year period with 18F-FDG PET/CT and MRI of shoulder performed within 45 days of each other and was used to enrich the study group. Group 3 included 109 randomly selected patients from the same time frame as groups 1 and 2 and was used to generate the control group. The study group consisted of 15 cases from the three groups, which had positive PET findings. PET/CT images were assessed in consensus by two musculoskeletal radiologists. The reference standard for a diagnosis of AC was clinical and was made by review of the medical record by a pain medicine physician. Results: The prevalence of focal activity at either the RI or IC (“positive PET”) was 0.53%. Nine patients had a clinical diagnosis of AC and 15 patients had a positive PET. The sensitivity and specificity of PET for detection of AC was 56% and 87%, respectively. PET/CT had a positive likelihood ratio for AC of 6.3 (95% CI: 2.8–14.6). Conclusions: Increased uptake at the RI or IC on PET/CT confers a moderate increase in the likelihood of AC.

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